Abstract
The insulin-like growth factors (IGFs) play essential roles in growth and development. A large body of experimental evidence has been accumulated that clearly indicates their importance in fetal growth and organogenesis, as well as their important roles in postnatal growth and in the specific function of various organ systems, including the immune, reproductive, nervous, and musculoskeletal systems 1, 2). Though the IGFs were originally considered to function as endocrine mediators, their expression in most tissues of the body suggests that both paracrine and autocrine mechanisms are equally important in IGF action at the cellular level (3, 4).
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LeRoith, D., Neuenschwander, S., Koval, A., Sindler, C., Roberts, C.T. (1995). Insulin-Like Growth Factors During Development. In: Blackman, M.R., Roth, J., Harman, S.M., Shapiro, J.R. (eds) GHRH, GH, and IGF-I. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-0807-5_5
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DOI: https://doi.org/10.1007/978-1-4612-0807-5_5
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