Interface Dermatitis

Abstract

Interface dermatitis is characterized by an inflammatory process, often with vacuolar changes, occurring at the interface of the epidermis and the dermis.

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Interface dermatitis is characterized by an inflammatory process, often with vacuolar changes, occurring at the interface of the epidermis and the dermis.

Table 14.1 The differential diagnosis of interface dermatitis

Fig. 14.1

Toxic epidermal necrolysis. There is full thickness epidermal necrosis and detachment of the epidermis from the underlying dermis

Fig. 14.2

Dermatomyositis. There is epidermal atrophy, vacuolar change at the dermal-epidermal junction and a sparse inflammatory infiltrate

Fig. 14.3

Lupus erythematosus. Epidermal atrophy with follicular hyperkeratosis and an interface, perivascular and periadnexal inflammatory infiltrate are observed

Fig. 14.4

Graft vs. Host disease. There is keratinocyte dyskeratosis and interface dermatitis