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Liver and Gall Bladder

  • Chapter
Fetal and Neonatal Pathology

Abstract

The embryology of the liver has been described in detail by Elias (1955) and Du Bois (1963). The hepatic anlage first appears about the 18th day of embryonic life as an endodermal diverticulum, arising from the duodenum. By the 25th day it forms a T-shaped outgrowth which is invaded by vessels derived from the vitelline and umbilical veins. The larger cephalad portion of the diverticulum, the pars hepatica, gives rise to the parenchymal cells and hepatic ducts, while the smaller caudal portion, the pars cystica, forms the gall bladder. The pars intermedia, linking the two portions, forms the cystic duct. It is now believed that the rudimentary bile ducts of the liver are derived from the parenchymal cells (Koga 1971; Ruebner et al. 1990) and are not, as was previously held, invaded by the developing duct system. The latter authors using im-munohistological techniques to demonstrate cytokeratins, carcinoembryonic antigen (CEA) and epithelial membrane antigen (EMA) have suggested there may be stages in the development of the interlobar bile ducts from the hepatocytes. Initially the ductal plate hepa-tocytes become flattened and show increased staining for cytokeratins. In the second phase these cells become cuboidal CEA negative and strongly EMA positive.

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Authors
  1. D. Ian Rushton
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Editors and Affiliations

  1. Department of Paediatric Pathology and Cytogenetics, Royal Hospital for Sick Children, Edinburgh, EH9 1LF, UK

    Jean W. Keeling MBBS, FRCPath, FRCP (Edin) (Consultant Paediatric Pathologist, Honorary Senior Lecturer in Pathology) (Consultant Paediatric Pathologist, Honorary Senior Lecturer in Pathology)

  2. University of Edinburgh, UK

    Jean W. Keeling MBBS, FRCPath, FRCP (Edin) (Consultant Paediatric Pathologist, Honorary Senior Lecturer in Pathology) (Consultant Paediatric Pathologist, Honorary Senior Lecturer in Pathology)

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© 1993 Springer-Verlag London

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Rushton, D.I. (1993). Liver and Gall Bladder. In: Keeling, J.W. (eds) Fetal and Neonatal Pathology. Springer, London. https://doi.org/10.1007/978-1-4471-3802-0_16

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  • DOI: https://doi.org/10.1007/978-1-4471-3802-0_16

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-3804-4

  • Online ISBN: 978-1-4471-3802-0

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