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A Parsimonious Model of Amplitude and Frequency Modulation of Episodic Hormone Secretory Bursts as a Mechanism for Ultradian Signalling by Endocrine Glands

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Ultradian Rhythms in Life Processes

Abstract

Organisms typically adapt to environmental cues and homeostatic perturbations by coordinated responses, which involve a time-ordered chain of biochemical, cellular, organ-specific and system-wide changes. A major challenge to adaptive and homeostatic responses is the temporal organization or sequential patterning of the response variables. Moreover, even under basal conditions when major exterior stresses are not imposed, coordinating signals within the organism must be regulated in relation to amplitude, frequency, duration and/or tonic output.

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References

  • Asplin CM, Faria ACS, Carlsen EC et al. (1989) Alterations in the pulsatile mode of growth hormone release in men and women with insulin-dependent diabetes mellitus. J Clin Endocrinol Metab 69: 239–245

    Article  PubMed  CAS  Google Scholar 

  • Barraclough CA, Wise PM (1982) The role of catecholamines in the regulation of pituitary LH and FSH secretion. Endocr Rev 3: 91–119

    Article  PubMed  CAS  Google Scholar 

  • Baumann G, Shaw MA, Buchanan TA (1989) In vivo kinetics of a covalent growth hormone-binding protein complex. Metabolism 38: 330–333

    Article  PubMed  CAS  Google Scholar 

  • Butler JP, Spratt DI, O’Dea LS, Crowley WF Jr (1986) Interpulse interval sequence of LH in normal men essentially constitutes a renewal process. Am J Physiol 250: E338–E340

    PubMed  CAS  Google Scholar 

  • Catt KJ, Loumaye E, Katikineni M, Hyde CL, Childs G, Amsterdam A, Naor Z (1983) Receptor and actions of gonadotropin releasing hormone (GnRH) on pituitary gonadotrophs. In: McCann SM and Dhindsa DS (eds) Role of peptides and proteins in control of reproduction. Elsevier, Amsterdam, pp 33–68

    Google Scholar 

  • Chase DJ, Schanbacher BD, Lunstra DD (1988) Effects of pulsatile and continuous luteinizing hormone (LH) infusion on testosterone responses to LH in rams actively immunized against gonadotropin-releasing hormone. Endocrinology 123: 816

    Article  PubMed  CAS  Google Scholar 

  • Clarke IJ, Cummins JT (1982) The temporal relationship between gonadotropin releasing hormone (GnRH) and luteinizing hormone (LH) secretion in ovariectomized ewes. Endocrinology 111: 1737–1740

    Article  PubMed  CAS  Google Scholar 

  • Daughaday WH (1981) Adenohypophysis. In: Williams RH (ed) Textbook of endocrinology. Saunders, Philadelphia, PA, pp 73–86

    Google Scholar 

  • Denef C, Andries M (1983) Evidence for paracrine interaction between gonadotrophs and lactotrophs in pituitary cell aggregates. Endocrinology 112: 813–818

    Article  PubMed  CAS  Google Scholar 

  • Dubdey AK, Ahanukoglu A, Hansen BC, Kowarski AA (1988) Metabolic clearance rates of synthetic human growth hormone in lean and obese male rhesus monkeys. J Clin Endocrinol Metab 67: 1064–1067

    Article  Google Scholar 

  • Dufau ML, Veldhuis JD (1987) Pathophysiological relationships between the biological and immunological activities of luteinizing hormone. In: Burger HG (ed) Bailliere’s clinical endocrinology and metabolism, vol 1. WB Saunders, Philadelphia, PA, pp 153–176

    Google Scholar 

  • Gambacciani M, Liu JH, Swartz WH, Tueros VS, Yens SC, Rasmussen DD (1987) Intrinsic pulsatility of LH release from the human pituitary in vitro. Neuroendocrinology 45: 402–406

    Article  PubMed  CAS  Google Scholar 

  • Gibson-Berry KL, Chase DJ (1990) Continuous and pulsatile infusions of luteinizing hormone have identical effects on steroidogenic capacity and sensitivity of Leydig cells in rats passively immunized against gonadotropin-releasing hormone. Endocrinology 126: 3107–3115

    Article  PubMed  CAS  Google Scholar 

  • Goodner CJ, Sweet IR, Courtenay-Harrison H (1988) Rapid reduction and return of surface insulin receptors after exposure to brief pulses of insulin in perifused rat hepatocytes. Diabetes 37: 1316–1323

    Article  PubMed  CAS  Google Scholar 

  • Grady RR, Charlesworth MC, Schwartz NB (1982) Characterization of the FSH-suppressing activity in follicular fluid. Recent Prog Horm Res 38: 409–456

    PubMed  CAS  Google Scholar 

  • Hartman ML, Veldhuis JD, Vance ML, Faria ACS, Furlanetto RW, Thorner MO (1990a) Somatotropin pulse frequency and basal growth hormone concentrations are increased in acromegaly. J Clin Endocrinol Metab 70: 1375–1384

    Article  PubMed  CAS  Google Scholar 

  • Hartman ML, Faria ACS, Vance ML, Johnson ML, Thorner MO, Veldhuis JDV (1990b) Temporal structure of in vivo growth hormone secretory events in man. Am J Physiol 260: E101–E110

    Google Scholar 

  • Hellman N, Nakada F, Curti J et al. (1970) Cortisol is secreted episodically in normal men. J Clin Endocrinol Metab 30: 411–422

    Article  PubMed  CAS  Google Scholar 

  • Ho KY, Veldhuis JD, Johnson ML et al. (1988) Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man. J Clin Invest 81: 968–975

    Article  PubMed  CAS  Google Scholar 

  • Hoffman AR, Crowley WF (1982) Induction of puberty in man by long-term pulsatile administration of low-dose gonadotropin-releasing hormone. N Engl J Med 307: 1237–1241

    Article  PubMed  CAS  Google Scholar 

  • Holl R, Hartman ML, Veldhuis JD, Taylor WM, Thorner MO (1991) Thirty second-sampling of plasma growth hormone (GH) in man: correlation with sleep stages. J Clin Endocrinol Metab 72: 854–861

    Article  PubMed  CAS  Google Scholar 

  • Iranmanesh A, Veldhuis JD, Samojlik E, Rogol AD, Johnson ML, Lizarralde G (1988) Alterations in the pulsatile properties of gonadotropin secretion in alcoholic men. J Androl 9: 207–214

    PubMed  CAS  Google Scholar 

  • Iranmanesh A, Lizarralde G, Johnson ML, Veldhuis JD (1989a) Circadian, ultradian and episodic release of beta endorphin in men, and its temporal coupling with Cortisol. J Clin Endocrinol Metab 68: 661–670

    Article  Google Scholar 

  • Iranmanesh A, Veldhuis JD, Johnson ML, Lizarralde G (1989b) Twenty-four hour pulsatile and circadian patterns of Cortisol secretion in alcoholic men. J Androl 10: 54–63

    PubMed  CAS  Google Scholar 

  • Iranmanesh A, Lizarralde G, Johnson ML, Veldhuis JD (1990) Dynamics of 24-hour endogenous Cortisol secretion and clearance in primary hypothyroidism assessed before and after thyroid hormone replacement. J Clin Endocrinol Metab 70: 155–161

    Article  PubMed  CAS  Google Scholar 

  • Iranmanesh A, Lizarralde G, Veldhuis JD (1991a) Age and relative adiposity are specific negative determinants of the frequency and amplitude of GH secretory bursts and the half-life of endogenous GH in healthy men. J Clin Endocrinol Metab 73: 1081–1088

    Article  PubMed  CAS  Google Scholar 

  • Iranmanesh A, Lizarralde G, Johnson ML, Veldhuis JD (1991b) Nature of the altered growth hormone secretion in hyperthyroidism. J Clin Endocrinol Metab 72: 108–115

    Article  PubMed  CAS  Google Scholar 

  • Iranmanesh A, Lizarralde G, Veldhuis JD (1992) Robustness of the male lactotropic axis to the hyperprolactinemic stimulus of primary thyroid failure. J Clin Endocrinol Metab (in press)

    Google Scholar 

  • Irvine CH, Alexander SL (1987) A novel technique for measuring hypothalamic and pituitary hormone secretion rates from collection of pituitary venous effluent in the normal horse. J Endocrinol 113: 183–192

    Article  PubMed  CAS  Google Scholar 

  • Isgaard J, Carlsson L, Isaksson OGP, Jansson JO (1988) Pulsatile intravenous growth hormone (GH) infusion to hypophysectomized rats increases insulin-like growth factor I messenger ribonucleic acid in skeletal tissues more effectively than continuous GH infusion. Endocrinology 123: 2605–2610

    Article  PubMed  CAS  Google Scholar 

  • Jansson JO, Albertsson-Wikland K, Eden S, Thorngren KG, Isaksson O (1982) Circumstantial evidence for a role of the secretory pattern of growth hormone in control of body growth. Acta Endocrinol (Copenh) 9: 24–30

    Google Scholar 

  • Jansson JO, Ekberg S, Hoath SB, Beamer WG, Frohman LA (1988) Growth hormone enhances hepatic epidermal growth factor receptor concentration in mice. J Clin Invest 82: 1871–1876

    Article  PubMed  CAS  Google Scholar 

  • Kasting NW, Martin JB, Arnold MA (1981) Pulsatile somatostatin release from the median eminence of the unanesthetized rat and its relationship to plasma growth hormone levels. Endocrinology 109: 1739–1745

    Article  PubMed  CAS  Google Scholar 

  • Knobil E (1980) Neuroendocrine control of the menstrual cycle. Recent Prog Horm Res 36: 53–88

    PubMed  CAS  Google Scholar 

  • Krieger DT (1979) Rhythms in CRF, ACTH and corticosteroids. In: Krieger DT (ed) Endocrine rhythms. Raven Press, New York, pp 123–142

    Google Scholar 

  • Krieger DT, Aschoff J (1979) Endocrine and other biological rhythms. In: DeGroott LJ (ed) Endocrinology, vol 2. Grune & Stratton, New York, pp 2079–2103

    Google Scholar 

  • Lang DA, Matthews DR, Peto J, Turner RC (1979) Cyclic oscillations of basal plasma glucose and insulin concentrations in human beings. N Engl J Med 301: 1023–1028

    Article  PubMed  CAS  Google Scholar 

  • Leong DA, Rawley LS, Neill JD (1983) Neuroendocrine control of prolactin secretion. Ann Rev Physiol 45: 109–131

    Article  CAS  Google Scholar 

  • Levine JE, Ramirez VD (1982) Luteinizing hormone-releasing hormone release during the rat estrous cycle and after ovariectomy, as estimated with push-pull cannulae. Endocrinology 111: 1439–1445

    Article  PubMed  CAS  Google Scholar 

  • Levine JE, Norman RL, Gliessman PM, Oyama TT, Bangsberg DR, Spies HG (1985) In vivo GnRH release and serum LH measurements in ovariectomized, estrogen-treated rhesus macaques. Endocrinology 117: 711–721

    Article  PubMed  CAS  Google Scholar 

  • Linkowski P, Mendlewicz J, Leclercq R et al. (1985) The 24-hour profile of adrenocorticotropin and Cortisol in major depressive illness. J Clin Endocrinol Metab 61: 429–438

    Article  PubMed  CAS  Google Scholar 

  • Manchester EL, Lye SJ, Challis JRG (1983) Activation of ovine fetal adrenal function by pulsatile or continuous administration on adrenocorticotropin-(l–24). II. Effects of adrenal cell responses in vitro. Endocrinology 113: 777–782

    Article  PubMed  CAS  Google Scholar 

  • Mauras N, Veldhuis JD (1990) Increased hGH production rate after low-dose estrogen therapy in prepubertal girls with Turner’s syndrome. Pediatr Res 28: 626–630

    Article  PubMed  CAS  Google Scholar 

  • Mauras N, Blizzard RM, Link K, Johnson ML, Rogol AD, Veldhuis JD (1987) Augmentation of growth hormone secretion during puberty: evidence for a pulse amplitude-modulated phenomenon. J Clin Endocrinol Metab 64: 596–601

    Article  PubMed  CAS  Google Scholar 

  • Mauras N, Rogol AD, Veldhuis JD (1989) Specific, time-dependent actions of low-dose estradiol administration on the episodic release of GH, FSH and LH in prepubertal girls with Turner’s syndrome. J Clin Endocrinol Metab 69: 1053–1058

    Article  PubMed  CAS  Google Scholar 

  • Moore-Ede MC, Czeisler CA, Richardson GS (1983) Circadian time-keeping in health and disease. N Engl J Med 309: 469–477

    Article  PubMed  CAS  Google Scholar 

  • Morley JE (1981) Neuroendocrine control of thyrotropin secretion. Endocr Rev 2: 396–436

    Article  PubMed  CAS  Google Scholar 

  • Nelson DH, Egdahl RH, Hume DM (1955) Corticosteroid secretion in the adrenal vein of the non-stressed dog exposed to cold. Endocrinology 58: 309 - 314

    Article  Google Scholar 

  • Nunley WC, Urban RJ, Kitchen JD, Bateman BG, Evans WS, Veldhuis JD (1990) Dynamics of pulsatile prolactin release during the postpartum lactational period. J Clin Endocrinol Metab 72: 287–293

    Article  Google Scholar 

  • Nunley WC, Urban RJ, Evans WS, Veldhuis JD (1991) Preservation of pulsatile LH release during postpartum lactational amenorrhea. J Clin Endocrinol Metab 73: 629–636

    Article  PubMed  CAS  Google Scholar 

  • Pavlou SN, Veldhuis JD, Linner J, Souza KH, Urban RJ, Rivier JE, Vale WW, Stallard DJ (1990) Persistence of concordant LH, testosterone and alpha subunit pulses following LHRH antagonist administration in normal men. J Clin Endocrinol Metab 70: 1472–1478

    Article  PubMed  CAS  Google Scholar 

  • Peluso JJ, Downey MC, Gruenberg ML (1984) Role of LH pulse amplitude in controlling rat ovarian estradiol-17beta secretion in vitro. J Reprod Fértil 71: 107–112

    Article  PubMed  CAS  Google Scholar 

  • Plotsky PM, Vale W (1985) Patterns of growth hormone-releasing factor and somatostatin secretion into the hypophysial-portal circulation of the rat. Science 230: 461–465

    Article  PubMed  CAS  Google Scholar 

  • Polonsky KS, Given BD, Pugh W, Licinio-Paixao J, Thompson JE, Karrison T, Rubenstein H (1985) Calculation of the systemic delivery rate of insulin in normal man. J Clin Endocrinol Metab 63: 113–120

    Article  Google Scholar 

  • Pool R (1989) Is it healthy to be chaotic? Science 243: 604–607

    Article  PubMed  CAS  Google Scholar 

  • Rivier C, Vale W (1983) Influence of the frequency of ovine corticotropin-releasing factor administration on adrenocorticotropin and corticosterone secretion in the rat. Endocrinology 113: 1422–1426

    Article  PubMed  CAS  Google Scholar 

  • Roberts V, Meunier H, Vaughan J et al. (1989) Production and regulation of inhibin subunits in pituitary gonadotropes. Endocrinology 124: 552–557

    Article  PubMed  CAS  Google Scholar 

  • St Arnaud R, La Chance R, DuPont A, Labrie F (1986) Serum luteinizing hormone (LH) biological activity in castrated patients with cancer of the prostate receiving a pure anti-androgen and in estrogen-pretreated patients with an LH-releasing hormone agonist and anti-androgen. J Clin Endocrinol Metab 63: 297–306

    Article  PubMed  CAS  Google Scholar 

  • Santoro N, Butler JP, Filicori M, Crowley WF Jr (1988) Alterations of the hypothalamic GnRH interpulse interval sequence over the normal menstrual cycle. Am J Physiol 225: E696–E701

    Google Scholar 

  • Seely EW, Conlin PR, Brent GA, Dluhy RG (1989) Adrenocorticotropin stimulation of aldosterone: prolonged continuous versus pulsatile infusion. J Clin Endocrinol Metab 69: 1028–1032

    Article  PubMed  CAS  Google Scholar 

  • Shupnik MA (1990) Effects of gonadotropin-releasing hormone on rat gonadotropin gene transcription in vitro: requirement for pulsatile administration for luteinizing hormone-beta gene stimulation. Mol Endocrinol 4: 1444–1450

    Article  PubMed  CAS  Google Scholar 

  • Sollenberger ML, Carlson EC, Johnson ML, Veldhuis JD, Evans WS (1990a). Specific physiological regulation of LH secretory events throughout the human menstrual cycle: new insights into the pulsatile mode of gonadotropin release. J Neuroendocrinol 2: 845–852

    Article  PubMed  CAS  Google Scholar 

  • Sollenberger MJ, Carlsen ES, Booth RA Jr, Johnson ML, Veldhuis JD, Evans WS (1990b) Nature of gonadotropin-releasing hormone self-priming of LH secretion during the normal menstrual cycle. Am J Obstet Gynecol 163: 1529–1534

    PubMed  CAS  Google Scholar 

  • Stewart JK, Clifton DK, Koerker DJ, Rogol AD, Jaffe J, Goodner CJ (1985) Pulsatile release of growth hormone and prolactin from the primate pituitary in vitro. Endocrinology 116: 1–5

    Article  PubMed  CAS  Google Scholar 

  • Swinney HL (1986) Perspectives on studies of chaos in experiments. In: Shlesinger MF, Cawley R, Saenz AW, Zachary W (eds) Perspectives in nonlinear dynamics. World Scientific, Singapore, pp 18–23

    Google Scholar 

  • Tannenbaum GS, Ling N (1984) The interrelationship of growth hormone (GH)-releasing factor and somatostatin in generation of the ultradian rhythm of GH secretion. Endocrinology 115: 1952–1957

    Article  PubMed  CAS  Google Scholar 

  • Thompson RG, Rodriguez A, Kowarski A, Blizzard RM (1972) Growth hormone: metabolic clearance rates, integrated concentrations, and production rates in normal adults and the effects of prednisone. J Clin Invest 51: 3193–3199

    Article  PubMed  CAS  Google Scholar 

  • Ulloa-Aguirre A, Blizzard RM, Garcia-Rubi E et al. (1990) Testosterone and oxandrolone, a non-aromatizable androgen, specifically amplify the mass and rate of growth hormone (GH) secreted per burst without altering GH secretory burst duration or frequency or the GH half-life. J Clin Endocrinol Metab 71: 846–854

    Article  PubMed  CAS  Google Scholar 

  • Urban RJ, Veldhuis JD (1991) Specific regulatory actions of dihydrotestosterone and estradiol on the dynamics of FSH secretion and clearance in man. J Androl 12: 27–35

    PubMed  CAS  Google Scholar 

  • Urban RJ, Veldhuis JD, Blizzard RM, Dufau ML (1988) Attenuated release of biologically active luteinizing hormone in healthy aging men. J Clin Invest 81: 1020–1029

    Article  PubMed  CAS  Google Scholar 

  • Urban RJ, Pavlou SN, Rivier JE, Vale WW, Dufau ML, Veldhuis JD (1990) Suppressive actions of a gonadotropin-releasing hormone (GnRH) antagonist on LH, FSH, and prolactin release in estrogen-deficient postmenopausal women. Am J Obstet Gynecol 162: 1255–1260

    PubMed  CAS  Google Scholar 

  • Urban RJ, Padmanabhan V, Beitins I, Veldhuis JD (1991) Metabolic clearance of human follicle- stimulating hormone in man as measured by radioimmunoassay, immunoradiometric assay, and in vitro Sertoli-cell bioassay. J Clin Endocrinol Metab 73: 818–823

    Article  PubMed  CAS  Google Scholar 

  • Valk TW, Corely KP, Kelch RP, Marshall JC (1980) Hypogonadotropic hypogonadism: hormonal responses to low dose pulsatile administration of gonadotropin-releasing hormone. J Clin Endocrinol Metab 51: 730–738

    Article  PubMed  CAS  Google Scholar 

  • Vance ML, Kaiser DL, Martha PM Jr, Furlanetto R, Rivier Vale W, Thorner MO (1989) Lack of in vivo somatotroph desensitization or depletion after 14 days of continuous growth hormone (GH)-releasing hormone administration in normal men and a GH-deficient boy. J Clin Endocrinol Metab 68: 22–28

    Article  PubMed  CAS  Google Scholar 

  • Veldhuis JD, Johnson ML (1988a) In vivo dynamics of luteinizing hormone secretion and clearance in man: assessment by deconvolution mechanics. J Clin Endocrinol Metab 66: 1291–1300

    Article  PubMed  CAS  Google Scholar 

  • Veldhuis JD, Johnson ML (1988b) A novel general biophysical model for simulating episodic endocrine gland signaling. Am J Physiol 255. E749–E759

    PubMed  CAS  Google Scholar 

  • Veldhuis JD, Johnson ML (1990a) New methodological aspects of evaluating episodic neuroendocrine signals. In: Yen SSC, Vale W (eds) Advances in neuroendocrine regulation of reproduction. Plenum Press, New York, pp 123–139

    Google Scholar 

  • Veldhuis JD, Johnson ML (1990b) Returning to the roots of endocrinology: the challenge of evaluating in vivo glandular secretory activity. Endocrinology 127: 2611–2617

    Article  PubMed  CAS  Google Scholar 

  • Veldhuis JD, Johnson ML (1991a) Deconvolution analysis of hormone data. Methods Enzymol 210: 539–575

    Article  Google Scholar 

  • Veldhuis JD, Johnson ML (1991b) A review and appraisal of deconvolution methods to evaluate in vivo neuroendocrine secretory events. J Neuroendocrinol 2: 755–771

    Article  Google Scholar 

  • Veldhuis JD, Beitins IZ, Johnson ML, Serabian MA, Dufau ML (1984) Biologically active luteinizing hormone is secreted in episodic pulsations that vary in relation to stage of the menstrual cycle. J Clin Endocrinol Metab 58: 1050–1058

    Article  PubMed  CAS  Google Scholar 

  • Veldhuis JD, Evans WS, Demers LM, Thorner MO, Wakat D, Rogol AD (1985) Altered neuroendocrine regulation of gonadotropin secretion in women distance runners. J Clin Endocrinol Metab 61: 557–563

    Article  PubMed  CAS  Google Scholar 

  • Veldhuis JD, Carlson ML, Johnson ML (1987a) The pituitary gland secretes in bursts: appraising the nature of glandular secretory impulses by simultaneous multiple-parameter deconvolution of plasma hormone concentrations. Proc Natl Acad Sci USA 84: 7686–7690

    Article  PubMed  CAS  Google Scholar 

  • Veldhuis JD, King JC, Urban RJ et al. (1987b) Operating characteristics of the male hypo- thalamo-pituitary-gonadal axis: pulsatile release of testosterone and follicle-stimulating hormone and their temporal coupling with luteinizing hormone. J Clin Endocrinol Metab 65: 929–941

    Article  PubMed  CAS  Google Scholar 

  • Veldhuis JD, Johnson ML, Dufau ML (1987c) Preferential release of bioactive luteinizing hormone in response to endogenous and low-dose exogenous gonadotropin releasing hormone (GnRH) pulses in man. J Clin Endocrinol Metab 64: 1275–1282

    Article  PubMed  CAS  Google Scholar 

  • Veldhuis JD, Faria A, Vance ML, Evans WS, Thorner ML, Johnson ML (1988a) Contemporary tools for the analysis of episodic growth hormone secretion and clearance in vivo. Acta Paediatr Scand 347: 63–82

    CAS  Google Scholar 

  • Veldhuis JD, Evans WS, Kolp LA, Rogol AD, Johnson ML (1988b) Physiological profiles of episodic progesterone release during the mid-luteal phase of the human menstrual cycle: analysis of circadian and ultradian rhythms, discrete pulse properties, and correlations with simultaneous LH release. J Clin Endocrinol Metab 66: 414–421

    Article  PubMed  CAS  Google Scholar 

  • Veldhuis JD, Johnson ML, Dufau ML (1989a) Physiological attributes of endogenous bioactive luteinizing hormone secretory bursts in man: assessment by deconvolution analysis and in vitro bioassay of LH. Am J Physiol 256: E199–E207

    PubMed  CAS  Google Scholar 

  • Veldhuis JD, Iranmanesh A, Lizarralde G, Johnson ML (1989b) Amplitude modulation of a burst-like mode of Cortisol secretion gives rise to the nyctohemeral glucocorticoid rhythm in man. Am J Physiol 257: E6–E14

    PubMed  CAS  Google Scholar 

  • Veldhuis JD, Urban RJ, Beitins I, Blizzard RM, Johnson ML, Dufau ML (1989c) Pathophysiological features of the pulsatile secretion of biologically active luteinizing hormone in man. J Steroid Biochem 33: 739–750

    Article  PubMed  CAS  Google Scholar 

  • Veldhuis JD, Evans WS, Stumpf P (1989d) Mechanisms subserving estradiol’s induction of increased prolactin concentrations in man: evidence for amplitude modulation of spontaneous prolactin secretory bursts. Am J Obstet Gynecol 161: 1149–1158

    PubMed  CAS  Google Scholar 

  • Veldhuis JD, Iranmanesh A, Johnson ML, Lizarralde G (1990a) Twenty-four hour rhythms in plasma concentration of adenohypophyseal hormones are generated by distinct amplitude and/or frequency modulation of underlying pituitary secretory bursts. J Clin Endocrinol Metab 71: 1616–1623

    Article  PubMed  CAS  Google Scholar 

  • Veldhuis JD, Iranmanesh A, Johnson ML, Lizarralde G (1990b) Amplitude, but not frequency, modulation of ACTH secretory bursts gives rise to the nyctohemeral rhythm of the corticotropic axis in man. J Clin Endocrinol Metab 71: 452–563

    Article  PubMed  CAS  Google Scholar 

  • Veldhuis JD, Lassiter AB, Johnson ML (1990c) Operating behavior of dual or multiple endocrine pulse generators. Am J Physiol 259: E351–E361

    PubMed  CAS  Google Scholar 

  • Veldhuis JD, Iranmanesh A, Ho KKY, Lizarralde G, Waters MJ, Johnson ML (1991) Dual defects in pulsatile growth hormone secretion and clearance subserve the hyposomatotropism of obesity in man. J Clin Endocrinol Metab 72: 51–59

    Article  PubMed  CAS  Google Scholar 

  • Veldhuis JD, Lizarralde G, Iranmanesh A (1992a) Divergent effects of short-term glucocorticoid excess on the gonadotropic and somatotropic axes in normal men. J Clin Endocrinol Metab 74: 96–102

    Article  PubMed  CAS  Google Scholar 

  • Veldhuis JD, Urban RJ, Lizarralde G, Johnson ML, Iranmanesh A (1992b) Attenuation of luteinizing hormone secretory burst amplitude as a proximate basis for the hypoandrogenism of healthy aging men. J Clin Invest (in press)

    Google Scholar 

  • Vieweg VW, Veldhuis JD, Carey RM (1992) Amplitude modulation of pulsatile aldosterone and renin release. Am J Physiol (in press)

    Google Scholar 

  • Watanabe T, Orth DN (1987) Detailed kinetic analysis of adrenocorticotropin secretion by dispersed anterior pituitary cells in a microperifusion system: effects of ovine corticotropin- releasing factor and arginine vasopressin. Endocrinology 121: 1133–1145

    Article  PubMed  CAS  Google Scholar 

  • Weiss TJ, Steele PA, Umapathysivam PK (1989) Perifusion of human granulosa-luteal cells: response to LH stimulation. Clin Endocrinol (Oxf) 31: 285–294

    Article  CAS  Google Scholar 

  • Winer LM, Shaw MA, Baumann G (1990) Basal plasma growth hormone levels in man: new evidence for rhythmicity of growth hormone secretion. J Clin Endocrinol Metab 70: 1678–1680

    Article  PubMed  CAS  Google Scholar 

  • Winters SJ (1990) Inhibin is released together with testosterone by the human testis. J Clin Endocrinol Metab 70: 548–550

    Article  PubMed  CAS  Google Scholar 

  • Winters SJ, Troen PE (1986) Testosterone and estradiol are co-secreted episodically by the human testis. J Clin Invest 78: 870–872

    Article  PubMed  CAS  Google Scholar 

  • Yen SSC, Lasley BL, Wang CF, Leblanc H, Siler TM (1975) The operating characteristics of the hypothalamic-pituitary system during the menstrual cycle and observations on biological action of somatostatin. Recent Prog Horm Res 31: 331–363

    Google Scholar 

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  1. J. D. Veldhuis
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Editors and Affiliations

  1. School of Pure and Applied Biology, University of Wales College of Cardiff, PO Box 915, Cardiff, CF1 3TL, Wales

    David Lloyd BSc, PhD, DSc (Professor of Microbiology) (Professor of Microbiology)

  2. C. G. Jung Institute of Los Angeles, 23708 Harbor Vista Drive, Malibu, CA, 90265, USA

    Ernest L. Rossi PhD (Clinical Psychologist) (Clinical Psychologist)

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© 1992 Springer-Verlag London Limited

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Veldhuis, J.D. (1992). A Parsimonious Model of Amplitude and Frequency Modulation of Episodic Hormone Secretory Bursts as a Mechanism for Ultradian Signalling by Endocrine Glands. In: Lloyd, D., Rossi, E.L. (eds) Ultradian Rhythms in Life Processes. Springer, London. https://doi.org/10.1007/978-1-4471-1969-2_8

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  • DOI: https://doi.org/10.1007/978-1-4471-1969-2_8

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  • Online ISBN: 978-1-4471-1969-2

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