Abstract
Photodynamic therapy (PDT) involves the therapeutic combination of a photosensitiser administered to the patient and its activation by light. This combination generates the formation of highly reactive oxygen intermediates which cause irreversible tissue injury and necrosis. Oxygen must be present in the tissue to effect damage. Van Tappeiner used this combination with eosin as the photosensitiser and artificial light for the treatment of skin carcinomas as early as 1903 but it was not until the 1970s that PDT became more widely investigated.
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References and Further Reading
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Lanigan, S.W. (2000). Photodynamic Therapy in Dermatology. In: Lasers in Dermatology. Springer, London. https://doi.org/10.1007/978-1-4471-0437-7_8
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DOI: https://doi.org/10.1007/978-1-4471-0437-7_8
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