Abstract
Sol-gel derived silica and titania have a specific interaction with many biological molecules, microbes, algae, cells and living tissue. The specific interactions mean that they differ from common reactions between non-viable materials and biomolecules or living tissues and the interactions are mostly beneficial from the viewpoint of biotechnical applications. Pepetides and proteins may preserve their activity and bacteria, algae and cells may preserve their viability and viruses their infectivity as encapsulated in sol-gel derived silica. Silica and titania are known to form a direct bond with living tissue which can be utilized in the biomaterial applications. Other application areas of silica and titania are in biosensing, tissue engineering, gene therapy, controlled delivery of therapeutic agents and environmental protection.
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L. Hench, R. J. Splinter, W. C. Allen and T.K. Greenlee, Bonding mechanisms at the interface of ceramic prosthetic materials, J. Biomed. Mater. Res. 2, 117-141 (1971).
L. L. Hench and J. Wilson, Introduction to Bioceramics (World Scientific, Singapore, 1993).
D. Avnir, S. Braun, O. Lev and M. Ottolenghi, Enzymes and other proteins entrapped in sol- gel materials, Chem. Mater. 6, 1605-1614 (1994).
I. Gill and A. Ballesteros, Bioencapsulation within synthetic polymers (Part 1): sol-gel encapsulated biologicals, Trends Biotech. 18, 282-196 (2000).
I. Gill, Bio-doped nanocomposite polymers: sol-gel bioencapsulates, Chem. Mater. 13, 3404-3421 (2001).
J. Livage, T. Choradin and C. Roux, Encapsulation of biomolecules in silica gels, J. Phys. Condens. Matter, 13, R673-R691 (2001).
C. J. Brinker and G. W. Scherer, Sol-Gel Science: The Physics and Chemistry of Sol-Gel Processing (Academic, San Diego, CA, 1990).
S. Sakka and H. Kozuka, Sol-Gel Processing (Kluwer, New York, 2005).
R. K. Iler, The Chemistry of Silica: Solubility, Polymerization, Colloid and Surface Properties, and Biochemistry (Wiley, New York, 1979).
R. Viitala, M. Jokinen, S. L. Maunu, H. Jalonen and J. B. Rosenholm, Chemical charac-terization of bioresorbable sol-gel derived SiO2 matrices Prepared at Protein-Compatible pH, J. Non-Cryst. Solid., 351, 3225-3234 (2005).
R. Viitala, M. Jokinen, J. B. Rosenholm, Mechanistic studies on release of large and small molecules from biodegradable SiO2, Int. J. Pharm. 336, 382-390 (2007).
M. Koskinen, M. Toriseva, M. Jokinen, H. Jalonen, J. Salonen and V.-M. Kähäri, Silica gel in targeted and controlled viral gene therapy, Mol. Ther. 11, S422-S427 (2005).
P. Kortesuo, M. Ahola, S. Karlsson, I. Kangasniemi, A. Yli-Urpo and J. Kiesvaara, Silica xerogels as an implantable carrier for controlled drug delivery - evaluation of drug distri-bution and tissue effects after implantation, Biomaterials, 21, 193-198 (2000).
M. Koskinen, E. Säilynoja, M. Ahola, H. Jalonen, J. Salonen and V.-M. Kähäri, Biodegradable carrier and method for preparation thereof, PCT Publication, WO02/80977 (2002)
M. Jokinen, M. Koskinen and H. Jalonen, Method of storing silica-based material, package produced with the method and use of package for packing of silica-based products, PCT Publication, WO2007/135224 (2007).
H. Knienapfel, C. Sprey, A. Wilke and P. Griss, Implant fixation by bone ingrowth. J. Arthoplasty, 14, 355-368 (1999).
H. U. Cameron, R. M. Pilliar and I. Macnab, The rate of bone ingrowth into porous metal. J. Biomed. Mater. Res., 10, 295-302 (1976).
J. D. Bodyn, R. M. Pilliar, H. U. Cameron and G. C. Weatherly, The optimum pore size for the fixation of porous-surfaced metal implants by the ingrowth of bone. Clin. Orthop., 150, 263-270 (1980).
D. Buser, R. K. Schenk, S. Steinemann, J. P. Fiorellini, C. H. Fox and H. Stich, Influence of surface characteristics on bone integration of titanium implants. A histomorphometric study in miniature pigs. J. Biomed. Mater. Res., 25, 889-902 (1991).
M. Wong, J. Eulenberger, R. Schenk and E. Hunziker, Effect of surface topology on the osseointegration of implant materials in trabecular bone. J. Biomed. Mater. Res., 29, 1567-1575 (1995).
A. Wennerberg, T. Albrektsson, B. Andersson and J. J. Krol, A histomorphometric and removal torque study of screw-shaped titanium implants with three different surface topo-graphies, Clin. Oral. Impl. Res., 6, 24-30 (1995).
T. Hayakawa, M. Yoshinari, H. Kiba, H. Yamamoto, K. Nemoto and J. A. Jansen, Trabecular bone response to surface roughened and calcium phosphate (Ca-P) coated titanium implants, Biomaterials, 23, 1025-1031 (2002).
S. Areva, Sol-Gel Derived Titania Based Ceramic Thin Films for Implant Coatings, Ph.D. thesis, Åbo Akademi University (Åbo Akademi tryckeri, Turku, 2006).
H. M. Kim, T. Himeno, M. Kawashita, J. H. Lee, T. Kokubo and T. Nakamura, Surface potential change in bioactive titanium metal during the process of apatite formation in simulated body fluid, J. Biomed. Mat. Res. Part A, 67A, 1305-1309 (2003).
P. Tengvall, H. Elwing, L. Sjöqvist, I. Lundström and L. M. Bjursten, Interaction between hydrogen peroxide and titanium: A possible role in the biocompatibility of titanium, Bio-materials, 10, 118-120 (1989).
P. Tengvall, I. Lundström, L. Sjöqvist and H. Elwing, Titanium-hydrogen peroxide inter-action: model studies of the influence of the inflammatory response on titanium implants, Biomaterials, 10, 166-175 (1989).
P. Tengvall and I. Lundström, Physico-chemical considerations of titanium as a biomaterial: Review paper. Clin. Mater., 9, 115-134 (1992).
P. Tengvall, H. Elwing and I. Lundström, Titanium gel made from metallic titanium and hydrogen peroxide, J. Colloid. Inter. Sci., 130, 405-413 (1989).
J.-M. Wu, S. Hayakawa, K. Tsuru and A. Osaka, Low-temperature preparation of anatase and rutile layers on titanium substrates and their ability to induce in vitro apatite deposition, J. Am. Chem. Soc., 87, 1635-1642 (2004).
C. Ohtsuki, H. Iida, S. Hayakawa and A. Osaka, Bioactivity of titanium treated with hydrogen peroxide solution containing metal chlorides, J. Biomed. Mater. Res., 35, 39-47 (1997).
X.-X. Wang, S. Hayakawa, K. Tsuru and A. Osaka, A comparative study of in vitro apatite deposition on heat-. H2O2-. and NaOH-treated titanium surfaces. J. Biomed. Mater. Res., 54, 172-178 (2001).
J.-M. Wu, S. Hayakawa, K. Tsuru and A. Osaka, Porous titania films prepared from inter- actions of titanium with hydrogen peroxide solution, Scripta Materialia, 46, 101-106 (2002).
R. G. T. Geesink, K. de Groot and C. P. A. T. Klein, Chemical implant fixation using hydroxyl-apatite coatings, Clin. Orthop., 225, 147-170 (1987).
K. de Groot, R. Geesing, C. P. A. T. Klein and P. Serekian, Plasma sprayed coatings of hydroxylapatite, J. Biomed. Mater. Res., 21, 1375-1381 (1987).
M. Ogiso, M. Yamamura, P. T. Kuo, D. Borgese and T. Matsumoto, A comparative push-out test of dense HA implants and HA-coated implants: findings in a canine study, J. Biomed. Mater. Res., 39, 364-372 (1998).
W. J. A. Dhert, C. P. A. T. Klein, J. G. C. Wolke, E. A. van der Velde, K. de Groot and P. M. Rozing, A mechanical investigation of fluorapatite, magnesiumwhitlockite, and hydroxylapatite plasma-sprayed coating on goats, J. Biomed. Mater. Res., 25, 1183-1200 (1991).
E. C. Combe, F. J. T. Burke and W. H. Douglas, Dental Biomaterials (Kluwer, London, 1999).
T. J. Webster, C. Ergun, R. H. Doremus, R. W. Siegel and R. Bizios, Specific proteins mediate enhanced osteoblast adhesion on nanophase ceramics, J. Biomed. Mater. Res., 51, 475-483 (2000).
T. J. Webster, C. Ergun, R. H. Doremus, R. W. Siegel and R. Bizios, Enhanced osteoclast-like cell functions on nanophase ceramics, Biomaterials, 22, 1327-1333 (2001).
M. J. Dalby, M. O. Richle, H. Johnstone, S. Affrossman and A. S. G. Curtis, In vitro reaction of endothelial cells to polymer demixed nanotopography, Biomaterials, 23, 2945-2954 (2002).
M. J. Dalby, M. O. Richle, D. S. Sutherland, H. Agheli and A. S. G. Curtis, Fibroblast response to a controlled nanoenvironment produced by colloidal lithography, J. Biomed. Mater. Res., 69, 314-322 (2004).
T. Brendel, A. Engel and C. Russel, Hyrdoxyapatite coating by a polymeric route, J. Mater. Sci. Mater. Med., 3, 175-179 (1992).
Q. Qiu, P. Vincent, B. Lowenberg, M. Sayer and J. E. Davies, Bone growth on sol-gel calcium phosphate thin films in vitro. Cells Mat., 3, 351-360 (1993).
D. B. Haddow, P. E. James and R. van Noort, Characterization of sol-gel surfaces for biomedical applications, J. Mater. Sci. Mater. Med., 7, 255-260 (1996).
W. Weng and J. L. Baptista, Sol-gel derived porous hydroxyapatite coatings, J. Mater. Sci. Mater. Med., 9, 159-163 (1998).
K. A. Gross, C. S. Chai, G. S. K. Kannangara, B. Ben-Nissan and L. Hanley, Thin hydroxyapatite coatings via sol-gel synthesis, J. Mater. Sci. Mater. Med., 9, 839-843 (1998).
D. M. Liu, Q. Yang and T. Troczynski, Sol-gel hydroxyapatite coatings on stainless steel substrates, Biomaterials, 23, 691-698 (2002).
L. Gan and R. Pilliar, Calcium phosphate sol-gel-derived thin films on porous-surfaced implants for enhanced osteoconductivity. Part I: Synthesis and characterization, Biomaterials, 25, 5302-5312 (2005).
P. Li and K. de Groot, Calcium phosphate formation within sol-gel prepared titania in vitro and in vivo, J. Biomed. Mater. Res., 27, 1495-1500 (1993).
P. Li, K. de Groot and T. Kokubo, Bonelike hydroxyapatite induction by sol-gel derived titania coating on a titanium substrate, J. Am. Ceram. Soc., 77, 1307-1315 (1994).
T. Peltola, M. Pätsi, H. Rahiala, I. Kangasniemi and A. Yli-Urpo, Calcium phosphate induction by sol-gel-derived titania coatings on titanium substrates in vitro, J. Biomed. Mater. Res., 41, 504-510 (1998).
P. Lalor and P. Revell, T-lymphocytes and titanium aluminum vanadium (TiAlV) alloy: evidence for immunological events associated with debris deposition. Clin. Mater., 12, 57-62 (1993).
H. P. von Schroeder, D. C. Smith, A. E. Gross, R. M. Pilliar, R. A. Kandel, R. Chernecky and S. J. Lugowski, Titanemia from total knee arthoplasty, J. Arthoplasty, 11, 620-625 (1996).
J. E. Gordon, The New Science of Strong Materials or Why You Don’t Fall Through the Floor (Penguin Books, England, 1976).
N. Moritz, M. Jokinen, T. Peltola, S. Areva and A. Yli-Urpo, Local induction of calcium phosphate formation on TiO2 coatings on titanium via surface treatment with a CO2 laser, J. Biomed. Mater. Res., 65, 9-16 (2003).
N. Moritz, E. Vedel, H. Ylänen, M. Jokinen, T. Peltola, S. Areva, M. Hupa and A. Yli-Urpo, Bioactive glass and sol-gel-derived TiO2 coatings, Mat. Tech. Adv. Perf. Mat., 1, 29-32 (2003).
N. Moritz, S. Areva, J. Wolk and T. Peltola, TF-XRD examination of surface reactive TiO2 coatings produced by heat-treatment and CO2-laser treatment, Biomaterials, 26, 4460-4467 (2005).
D. J. Taylor, D. P. Birnie and B. D. Fabes, Temperature calculations for laser irradiated sol-gel films on oxide substrate, J. Mater. Res., 10, 1429-1434 (1995).
S. Pelli, G. C. Reghine, A. Scaglione, C. Ascoli, C. Frediani, A. Martucci and M. Guglielmi, Characterization of laser written sol-gel strip waveguides, SPIE Proc., 2288, 573-590 (1994).
S. Pelli, G. C. Reghine, A. Scaglione, M. Guglielmi and A. Martucci, Direct writing of ridge optical waveguides on silica- titania glass sol-gel films, J. Opt. Mater., 5, 119-126 (1996).
R. E. Day and G. D. Parfitt, Characterization of the surface of rutile by nitrogen and water vapour adsorption, Trans. Faraday Soc., 63, 708-716 (1967).
K. E. Lewis and G. D. Parfitt, Infra-red study of the surface of rutile, Trans Faraday Soc., 62, 204-214 (1965).
W. H. Wade and N. Hackerman, Heats of immersion in TiO2-H2O system-variations with particle sizes and outgassing temperature, J. Phys. Chem., 65, 1681-1683 (1961).
C. Monterra, An infrared spectroscopic study of anatase properties. Part 6. Surface hydration and strong lewis acidity of pure and sulphate-doped preparations, J. Chem. Soc. Faraday Trans., 1, 1617-1637 (1988).
M. Jokinen, M. Patsi, H. Rahiala, T. Peltola, M. Ritala and J. B. Rosenholm, Influence of sol and surface properties on in vitro bioactivity of sol-gel-derived TiO2 and TiO2-SiO2 films deposited by dip-coating method, J. Biomed. Mater. Res., 4, 295-302 (1998).
T. Peltola, M. Jokinen, H. Rahiala, M. Pätsi, J. Heikkilä, I. Kangasniemi and A. Yli-Urpo, Effect of aging time of sol on structure and in vitro calcium phosphate formation of sol-gel-derived titania films, J. Biomed. Mater. Res., 51, 200-208 (2000).
T. Peltola, H. Paldan, N. Moritz, S. Areva, J. Korventausta, M. Jokine, T. Narhi, R. P. Happonen and A. Yli-Urpo, Methods to enhance biomimetic activity and ability to tissue bonding of sol-gel-derived nanoporous titania, Key Eng. Mat., 218-220, 207-212 (2002).
M. Uchida, H. M. Kim, T. Kokubo and T. Nakamura, Structural dependence of apatite formation on titania gel in simulated body fluid, J. Biomed. Mater. Res., 64, 164-170 (2003).
J.-M. Wu, S. Hayakawa, K. Tsuru and A. Osaka, Low-temperature preparation of anatase and rutile layers on titanium substrates and their ability to induce in vitro apatite deposition, J. Am. Chem. Soc., 87, 1635-1642 (2004).
W. A. Ganong and A. Lange, Medical Book: Review of Medical Physiology (Lange Medical Publications, Los Altos, CA, 1987).
T. Peltola, Nanoscale Dimensions and In Vitro Calcium Phosphate Formation: Studies on Sol-Gel Derived Materials and Bioactive Glass, Ph.D. thesis, University of Turku (Typopress Oy, Turku, 2000).
S. Mann, Biominerilization (Oxford University Press, Oxford, 2001).
S. Areva, P. Paldan, T. Peltola, T. Närhi, M. Jokinen and M. Lindén, Use of sol-gel derived titania coating for direct soft tissue attachment, J. Biomed. Mater. Res., 70A, 169-178 (2004).
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Viitala, R., Areva, S., Jokinen, M., Koskinen, M. (2008). About Interactions Between Sol-Gel Derived Silica, Titania and Living Organisms. In: Innocenzi, P., Zub, Y.L., Kessler, V.G. (eds) Sol-Gel Methods for Materials Processing. NATO Science for Peace and Security Series C: Environmental Security. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8514-7_15
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