Abstract
As was mentioned in chapter 1, there have been a number of theories concerning the aetiology of dental caries, of which the acidogenic theory has been the most generally accepted. According to this theory, caries is initiated by organic acids produced by oral bacteria as a result of their fermentative activity on carbohydrates. The credit for the ‘Chemicoparasitic’ or acidogenic theory is usually ascribed to W. D.Miller1, but it is fair to say that his conclusions were based on the accumulated efforts of a number of other investigators, as well as his own, during the nineteenth century. In 1897, N. B. Williams reported his observation that the enamel of human teeth was covered with adhesive ‘gelatine-like’ material, consisting largely of microorganisms, and suggested that this material might be responsible for the localisation of acid attack to certain areas of the tooth surface. Writing a year later, G. V. Black coined the phrase ‘gelatinous microbial plaques’ for the bacteria on the tooth surface, and supported the idea that acid-producing bacteria were the main aetiological agents in caries.
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Further reading
Bibby, B. G. and Shern, R. J. (Eds) (1978). Methods of Caries Prediction. A Special Supplement of Microbiology Abstracts, Information Retrieval Inc., Washington D.C. and London
Newbrun, E. (1978). Cariology. Williams and Wilkins Co., Baltimore
Kleinberg, I., Ellison, S. A. and Mandel, I. D. (Eds) (1979). Saliva and Dental Caries. A Special Supplement of Microbiology Abstracts, Information Retrieval Inc., New York and London
Stiles, H. M., Loesche, W. J. and O’Brien, T. C. (1976). Microbial Aspects of Dental Caries. A Special Supplement of Microbiology Abstracts, Information Retrieval Inc., Washington D. C. and London
References
Miller, W. D. (1890). The Micro-organisms of the Human Mouth, S. S. White Dental Manufacturing Co., Philadelphia. Republished, K. König (Ed.), by S. Karger, Basel, 1973
Schroeder, H. E. and De Boever, J. (1970). The structure of microbial dental plaque, in Dental Plaque (Ed. McHugh, W. D. ), E. and S. Livingstone, Edinburgh and London, pp. 49–75
Silverstone, L. M. (1968). The surface zone in caries and in caries-like lesions produced in vitro. British Dental Journal, 125, 145–157
Hardie, J. M., Silverstone, L. M. and Bowden, G. H. (1971). Modification of acid attack on enamel surfaces in vitro, by aggregations of bacteria. Caries Research, 5, 290–304
Pigman, W, Elliot, H. C. and Laffre, R. O. (1952). An artificial mouth for caries research. Journal of Dental Research, 31, 627–33
Pigman, W. (1968). In vitro simulation of dental caries using bacteria, in Art and Science of Dental Caries Research (Edited Harris, R. S.), Academic Press, New York and London, pp. 319–30
Sidaway, D. A. (1970). The bacterial composition of natural plaque and the in vitro production of artificial plaque, in Dental Plaque (Ed. McHugh, W. D. ), E. and S. Livingstone, Edinburgh and London
Coulter, W. A. and Russell, C. (1976). pH and Eh in single and mixed culture bacterial plaque in an artificial mouth. Journal of Applied Bacteriology, 40, 73–87
Ellwood, D. C., Hunter, J. R. and Longyear, V. M. C. (1974). Growth of Streptococcus mutans in a chemostat. Archives of Oral Biology, 19, 659–64
McClure, F. J. and Hewitt, W. L. (1946). Relation of penicillin to induced rat dental caries and oral Lactobacillus acidophilus Journal of Dental Research, 25, 441–3
Hill, T. J. Sims, J and Newman, M. (1953). The effect of penicillin dentifrice on the control of dental caries. Journal of Dental Research, 32, 448–52
Zander, H. A. (1950). The effect of pencillin dentifrice on caries incidence in school children. Journal of the American Dental Association, 40, 569–74
Littleton, N. W. and White, C. L. (1964). Dental findings from a preliminary study ofchildren receiving extended antibiotic therapy. Journal of the American Dental Association, 68, 520–5
Handleman, S. L., Mills, J. R. and Hawes, R. R. (1966). Caries incidence in subjects receiving long term antibiotic therapy. Journal of Oral Therapeutics and Pharmacology, 2, 338–45
Bibby, B. G. (1970). Antibiotics and dental caries, in Dietary Chemicals vs. Dental Caries, Advances in Chemistry Series 94 (Ed. Gould, R. F. ), American Chemical Society, Washington, DC
Loesche, W. J. (1976). Chemotherapy of dental plaque infections. Oral Sciences Reviews, 9, 65–107
Orland, F. J., Blayney, J. R., Harrison, R. W., Reyniers, J. A., Trexler, P. C., Gordon, H. A., Wagner, M. and Luckey, T. D. (1954). Use of germ-free animal technique in the study of experimental dental caries. 1. Bâsic observations on rats reared free of all microorganisms. Journal of Dental Research, 33, 147–74
Fitzgerald, R. J. and Keyes, P. H. (1960). Demonstration of the etiologic role of streptococci in experimental caries in the hamster. Journal of the American Dental Association, 61, 9–19
Fitzgerald, R. J., Jordan, H. V. and Stanley, H. R. (1960). Experimental caries and gingival pathologic changes in the gnotobiotics rat. Journal of Dental Research, 39, 923–35
Keyes, P. H. (1960). The infections and transmissible nature of experimental dental caries-findings and implications. Archives of Oral Biology, 1, 304–20
Zinner, D. D., Jablon, J. M., Aran, A. P. and Saslaw, M. S. (1966). Comparative pathogenicity of streptococci of human origin in hamster caries. Archives of Oral Biology, 11, 1419–20
Gibbons, R. J., Berman, K. S., Knoettner, P. and Kapsimalis, B. (1966). Dental caries and alveolar bone loss in gnotobiotic rats infected with capsule-forming streptococci of human origin. Archives of Oral Biology, 11, 549–60
Edwardsson, S. (1968). Characteristics of caries-inducing human streptococci resembling Streptococcus mutans. Archives of Oral Biology, 13, 637–46
Krasse, B. (1966). Human streptococci and experimental caries in hamsters. Archives of Oral Biology, 11, 429–36
Guggenheim, B. (1968). Streptococci of dental plaques. Caries Research, 2, 147–63
Fitzgerald, R. J. (1968). Dental caries research in gnotobiotic animals. Caries Research, 2, 139–46
Konig, K. G. (1968). Design of animal experiments in caries research, in Art and Science of Dental caries Research (Ed. Harris, R. S. ), Academic Press, New York and London
Krasse, B. and Carlsson, J. (1970). Various types of streptococci and experimental caries in hamsters. Archives of Oral Biology, 15, 25–32
Bowen, W. H. (1968). Dental caries in monkeys. Advances in Oral Biology, 3, 185–216
Lehner, T., Challacombe, S. J. and Caldwell, J (1975). An experimental model for immunological studies of dental caries in the Rhesus monkey. Archives of Oral Biology, 20, 299–304
Mikx, F. H. M., Hoeven, J. S. van der., Konig, K. G., Plasschaert, A. J. M. and Guggenheim, B. (1972). Establishment of defined microbial ecosystems in germfree rats. 1. Effect of the interaction of Streptococcus mutans or Streptococcus sanguis with Veillonella alcalescens on plaque formation and caries activity. Caries Research, 6, 211–21
Fitzgerald, R. J., Jordan, H. V. and Archard, H. O. (1966). Dental caries in gnotobiotic rats infected with a variety of Lactobacillus acidophilus. Archives of Oral Biology, 11, 473–76
Fillery, E. D., Bowden, G. H. and Hardie, J. M. (1978). A comparison of strains of bacteria designated Actinomyces viscosus and Actinomyces naeslundii. Caries Research, 12, 299–312
Krasse, B., Jordan, H. V., Edwardsson, S., Svensson, I. and Trell, L. (1968). The occurrence of certain `caries-inducing’ streptococci in human dental plaque material. Archives of Oral Biology, 13, 911–18
Littleton, N. W., Kakehashi, S. and Fitzgerald, R. J. (1970). Recovery of specific `caries-inducing’ streptococci from carious lesions in the teeth of children. Archives of Oral Biology, 15, 461–3
Shklair, I. L., Keene, H. J. and Simons, L. G. (1972). Distribution and frequency of Streptococcus mutans in caries-active individuals. Journal of Dental Research, 51, 882
Rogers, A. H. (1973). The ecology of Streptococcus mutans in carious lesions and on caries-free surfaces of the same tooth. Australian Dental Journal, 18, 226–8
Hoerman, K. C., Keene, H. J., Shklair, I. L. and Burmeister, J. A. (1972). The association of Streptococcus mutans with early carious lesions in human teeth. Journal of the American Dental Association, 85, 1349–52
Shklair, I. L., Keene, H. J. and Cullen, P. (1974). The distribution of Streptococcus mutans on the teeth of two groups of naval recruits. Archives of Oral Biology, 19, 199–202
Keene, H. J. and Shklair, I. L. (1974). Relationship of Streptococcus mutans carrier status to the development of carious lesions in initially caries free recruits. Journal of Dental Research, 53, 1295
Ikeda, T., Sandham, H. J. and Bradley, E. L. Jr. (1973). Changes in Streptococcus mutans and lactobacilli in plaque in relation to the initiation of dental caries in Negro children. Archives of Oral Biology, 18, 555–66
Mikkelsen, L. and Poulsen, S. (1976). Microbiological studies on plaque in relation to development of dental caries in man. Caries Research, 10, 178–88
Loesche, W. J., Rowan, J., Straffon, L. H. and Loos, P. J. (1975). Association of Streptococcus mutans with human dental decay. Infection and Immunity, 11, 1252–60
Sumney, D. L. and Jordan, H. V. (1974). Characterization of bacteria isolated from human root surface carious lesion. Journal of Dental Research, 53, 343–51
Syed, S. A., Loesche, W. J., Pape, H. L., Jr., and Grenier, E. (1975). Predominant cultivable flora isolated from human root surface caries plaque. Infection and Immunity, 11, 727–31
Yamada, T. and Carlsson, J. (1975). Regulation of lactate dehydrogenase and change of fermentation products in streptococci. Journal of Bacteriology, 124, 5561
Geddes, D. A. M. (1975). Acids produced by human dental plaque metabolism in situ. Caries Research, 9, 98–109
De Stoppelaar, J. D., Konig, K. G., Plasschaert, A. J. M. and van der Hoeven, J. S. (1971). Decreased cariogenicity of a mutant of Streptococcus mutans. Archives of Oral Biology, 16, 971–5
Bratthall, D. (1970). Demonstration of five serological groups of streptococcal strains resembling Streptococcus mutans. Odontologisk Revy., 21, 143–52
Perch, B., Kjems, E. Ravn, T. (1974). Biochemical and serological properties of Streptococcus mutans from various human and animal sources. Acta Pathologica et Microbiologica Scandinavica, Section B, 82, 357–70
Coykendall, A. L. (1970). Base composition of deoxyribonucleic acid isolated from cariogenic streptococci. Archives of Oral Biology, 15, 365–68
Coykendall, A. L. (1974). Four types of Streptococcus mutans based on their genetic, antigenic and biochemical characteristics. Journal of General Microbiology, 83, 327–38
Hardie, J. M. and Bowden, G. H. (1974). Cell wall and serological studies on Streptococcus mutans. Caries Research, 8, 301–16
Linzer, R. (1976). Serotype polysaccharide antigens of Streptococcus mutans: composition and serological cross-reactions, in Immunologic Aspects of Dental Caries (Eds. Bowen, W. H., Genco, R. J. and O’Brian, T. C. ), Information Retrieval Inc., Washington, DC and London
Socransky, S. S. (1968). Caries susceptibility tests. Annals of the New York Academy of Sciences, 153, 137–46
Sims, W. (1970). The interpretation and use of Synder tests and lactobacillus counts. Journal of the American Dental Association, 80, 1315–19
Ellen, R. P. (1976). Microbiological assays for dental caries and periodontal disease susceptibility. Oral Sciences Review, 8, 323
Llory, H., Dammron, A. and Frank, R. M. (1971). Changes in the oral flora following bucco-pharyngeal radiotherapy. Archives of Oral Biology, 16, 617–30
Brown, L. R. Dreizen, S., Handler, S. and Johnston, D. A. (1975). Effect of radiation-induced xerostamia on human oral micro flora. Journal of Dental Research, 54, 740–50
Dogon, I. L., Kerr, A. C. and Amdur, B. H. (1962). Characterization of an antibacterial factor in human parotid secretions, active against Lactobacillus casei. Archives of Oral Biology, 7, 81–90
Hoogendoorn, H (1974). The effect of lactoperoxidase-thiocyanate-hydrogen peroxide on the metabolism of cariogenic microorganisms in vitro and in the oral cavity. Doctoral Thesis, Univ. of Delft
Gibbons, R. J. and Spinnell, D. M. (1970). Salivary induced aggregation of plaque bacteria, in Dental Plaque (Ed. McHugh, W. D. ), E. S. Livingstone, Edinburgh and London, pp. 207–16
Magnusson, I., Ericson, Th. and Pruitt, K. (1976). Effect of salivary agglutinins on bacterial colonization of tooth surfaces. Caries Research, 10, 113–22
Mergenhagen, S. E. and Scherp, H. W. (Eds) (1973). Comparative Immunology of the Oral Cavity, DHEW Publications No. (NIH) 73–438, US Department of Health, Education and Welfare, National Institutes of Health, Bethesda, Maryland
Lehner, T. (1975). Immunological aspects of dental caries and periodontal disease. British Medical Bulletin, 31, 125–30
Brandtzaeg, P. (1974). Immunoglobulin systems of oral mucosa and saliva, in The Oral Mucosa in Health and Disease (Ed. Dolby, A. E. ), Blackwell Scientific Publications, Oxford
Lehner, T., Cardwell, J. D. and Clarry, E. D. (1967). Immunoglobulins in saliva and serum in dental caries. Lancet, 1, 1294–7
Zengo, A. N., Mandel, I. D., Goldman, R. and Khurana, H. S. (1971). Salivary studies in human caries resistance. Archives of Oral Biology, 16, 557–60
Brandtzaeg, P., Fjellanger, I. and Gjeruldsen, S. T. (1970). Human secretory immunoglobulins-I. Salivary secretions from individuals with normal or low levels of serum immunoglobulins. Scandinavian Journal of Haematology, Supplement 12
Lindstrom, F. D. and Folk, L. E. A. (1973). Salivary IgA in periodontal disease. Acta Odontologica Scandinavica, 31, 31–4
Mandel, I. D. and Khurana, H. S. (1969). The relation of human salivary y A globulin and albumin to flow rate. Archives of Oral Biology, 14, 1433–5
Brandtzaeg, P. (1971). Human secretory immunoglobulins VII: Concentration of parotid IgA and other secretory proteins in relation to the rate of flow and duration of secretory stimulus. Archives of Oral Biology, 16, 1295–1310
Orstavik, D. and Brandtzaeg, P. (1975). Secretion of parotid IgA in relation to gingival inflammation and dental caries experience in man. Archives of Oral Biology, 20, 701–4
Challacombe, S. J., Guggenheim, B. and Lehner, T. (1973). Antibodies to an extract of Streptococcus mutans, containing glucosyltransferase activity, related to dental caries in man. Archives of Oral Biology, 18, 657–68
Hardie, J. M. and Bowden, G. H. (1976). Some serological cross-reactions between Streptococcus mutans, Streptococcus sanguis and other dental plaque streptococci. Journal of Dental Research, 55, c50 - c58
Knox, K. W. and Wicken, A. J. (1973). Immunological properties of teichoic acids. Bacteriological Reviews, 37, 215–57
Kennedy, A. E., Shklair, I. L., Hayashi, J. A. and Bahu, A. N. (1968). Antibodies to cariogenic streptococci in humans. Archives of Oral Biology, 13, 1275–8
Lehner, T., Wilton, J. M. A. and Ward, R. G. (1970). Serum antibodies in dental caries in man. Archives of Oral Biology, 15, 481–90
Challacombe, S. J. (1974). Serum complement-fixing antibodies in human dental caries. Caries Research, 8, 84–95
Sims, W. (1970). The concept of immunity in dental caries 1. General considerations. Oral Surgery, Oral Medicine, Oral Pathology, 30, 670–7
Sims, W. (1972). The concept of immunity in dental caries II. Specific immune responses. Oral Surgery, Oral Medicine, Oral Pathology, 34, 69–86
Bowden, G. H. Hardie, J. M., McKee, A. S., Marsh, P. D., Fillery, E. D. and Slack, G. L. (1976). The microflora associated with developing carious lesions of the distal surfaces of the upper first premolars in 1314 year old children. Microbial Aspects of Dental Caries, Stiles, H. M., Loesche, W. J. and O’Brien, T. C. (Eds.) Special supplement of Microbiology Abstracts vol. 1, 223–41, Information Retrieval Inc., Washington, DC and London
Hardie, J. M., Thomson, P. L., South, R. J., Marsh, P. D., Bowden, G. H., McKee, A. S., Fillery, E. D. and Slack, G. L. (1977). A longitudinal epidemiological study on dental plaque and the development of caries - interim results after two years. Journal of Dental Research 56, c90 - c98.
Drucker, D. B. and Green, R. M. (1978). The relative cariogenicities of Streptococcus milleri and other viridans group streptococci in gnotobiotic hooded rats. Archives of Oral Biology, 23, 183–7
Drucker, D. B. and Green, R. M. (1979). Potential of streptococci for inducing dental caries in gnotobiotic rats, in Pathogenic Streptococci (Ed. Parker, M. T. ), Reed Books Ltd, Surrey, pp. 206–7
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© 1981 L. M. Silverstone, N. W. Johnson, J. M. Hardie and R. A. D. Williams
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Silverstone, L.M., Johnson, N.W., Hardie, J.M., Williams, R.A.D. (1981). The Microbiology of Dental Caries. In: Dental Caries. Palgrave, London. https://doi.org/10.1007/978-1-349-16547-6_3
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