Abstract
Severe sepsis and septic shock are among the leading causes of death, representing the 10th most common cause of death in the United States of America [1]. The high mortality rates, ranging between 35 and 50 % despite adequate antimicrobial treatment [2], have encouraged intense research efforts to better understand the mechanisms underlying the pathogenesis of sepsis. As a consequence, sepsis syndrome is now recognized as a complex entity created by an intense inflammatory reaction that is generated in the host after stimulation of the innate and adaptive immune systems by bacterial components [3].
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Giamarellos-Bourboulis, E.J. (2009). Clarithromycin: A Promising Immunomodulator in Sepsis. In: Vincent, JL. (eds) Intensive Care Medicine. Springer, New York, NY. https://doi.org/10.1007/978-0-387-92278-2_11
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DOI: https://doi.org/10.1007/978-0-387-92278-2_11
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