Abstract
VEGF is best known for its angiogenic properties. Not only does it promote the growth of new blood vessels during embryonic development, it is also important in the adult, where it plays a role in maintaining an adequate supply of oxygen and nutrients to most tissues. VEGF gene regulation is controlled by different signalling pathways depending on the context in which it is expressed. Best understood is the induction of VEGF expression by hypoxia in neonates and adults, which represents an adaptive response to metabolic stress. In contrast, the mechanisms that control VEGF expression during embryonic development are currently less clear.
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Keywords
- Vascular Endothelial Growth Factor
- Vascular Endothelial Growth Factor mRNA
- Vascular Endothelial Growth Factor Gene
- VEGF Expression
- Retinal Vasculature
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Fruttiger, M. (2008). VEGF Gene Regulation. In: VEGF in Development. Molecular Biology Intelligence Unit. Springer, New York, NY. https://doi.org/10.1007/978-0-387-78632-2_3
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DOI: https://doi.org/10.1007/978-0-387-78632-2_3
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