Oncologic imaging of the pancreas is a challenging entity due to a large number of primary pancreatic neoplasms, as well as benign entities of the pancreas that simulate neoplasms, such as inflammatory and cystic disease. While clinical and laboratory data are able to distinguish many of the disease processes affecting the pancreas, imaging is inevitably tied to diagnosis and treatment, given the significant overlap of patient symptoms in benign and malignant pancreatic disorders. In general primary pancreatic neoplasms can be divided into three categories: solid, cystic and neuroendocrine tumors. All three of these can overlap in common imaging findings, and familiarity with available imaging modalities can help differentiate these tumors from benign disease. This chapter will discuss current and emerging techniques in pancreatic imaging, as well as their integration with oncologic care.
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Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics, 2007. CA Cancer J Clin. 2007 Jan-Feb;57(1):43–66.
Lowenfels AB, Maisonneuve P. Epidemiology and prevention of pancreatic cancer. Jpn J Clin Oncol. 2004 May;34(5):238–44.
Lowenfels AB, Maisonneuve P, Cavallini G, et al. Pancreatitis and the risk of pancreatic cancer. International Pancreatitis Study Group. N Engl J Med 1993;328:1433–7.
Lowenfels AB, Maisonneuve P, DiMagno EP, et al. Hereditary pancreatitis and the risk of pancreatic cancer. International Hereditary Pancreatitis Study Group. J Natl Cancer Inst.1997;89:442–6
Spinelli KS, Fromwiller TE, Daniel RA, et al. Cystic pancreatic neoplasms: observe or operate. Ann Surg. 2004 May;239(5):651–7.
Tada M, Kawabe T, Arizumi M, et al. Pancreatic cancer in patients with pancreatic cystic lesions: a prospective study in 197 patients. Clin Gastroenterol Hepatol. 2006 Oct;4(10):1265–70.
Hruban RH, Adsay NV, Albores-Saavedra J, et al. Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions. Am J Surg Pathol. 2001 May;25(5):579–86.
Maitra A, Adsay NV, Argani P, et al. Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray. Mod Pathol. 2003 Sep;16(9):902–12.
Kimura W, Nagai H, Kuroda A, Muto T, Esaki Y. Analysis of small cystic lesions of the pancreas. Int J Pancreatol. 1995 Dec;18(3):197–206.
Zhang XM, Mitchell DG, Dohke M, Holland GA, Parker L. Pancreatic cysts: depiction on single-shot fast spin-echo MR images. Radiology. 2002 May;223(2):547–53.
Brugge WR. Cystic pancreatic lesions: can we diagnose them accurately? What to look for. FNA marker molecular analysis resection, surveillance, or endoscopic treatment? Endoscopy. 2006 Jun;38 Suppl 1:S40–7.
Sahani DV, Kadavigere R, Saokar A, Fernandez-del Castillo C, Brugge WR, Hahn PF. Cystic pancreatic lesions: a simple imaging-based classification system for guiding management. Radiographics. 2005 Nov-Dec;25(6):1471–84.
Nichols MT, Russ PD, Chen YK. Pancreatic imaging: current and emerging technologies. Pancreas. 2006 Oct;33(3):211–20.
Bronstein YL, Loyer EM, Kaur H, et al. Detection of small pancreatic tumors with multiphasic helical CT. AJR Am J Roentgenol. 2004 Mar;182(3):619–23.
Ariyama J, Suyama M, Satoh K, Sai J. Imaging of small pancreatic ductal adenocarcinoma. Pancreas. 1998 Apr;16(3):396–401.
Manoharan P, Sheridan M B. Neoplasms of the Pancreas. Imaging 2004. (16): 323–337.
Mergo PJ, Helmberger TK, Buetow PC, Helmberger RC, Ros PR. Pancreatic neoplams: MR imaging and pathologic correlation. Radiographics. 1997 Mar-Apr;17(2):281–301.
Finkelberg DL, Sahani D, Deshpande V, Brugge WR. Autoimmune pancreatitis. N Engl J Med. 2006 Dec 21;355(25):2670–6
Sahani DV, Kalva SP, Farrell J, et al. Autoimmune pancreatitis: imaging features. Radiology. 2004 Nov;233(2):345–52.
Brugge WR, Lauwers GY, Sahani D, Fernandez-del Castillo C, Warshaw AL. Cystic neoplasms of the pancreas. N Engl J Med. 2004 Sep 16;351(12):1218–26.
Kawamoto S, Lawler LP, Horton KM, Eng J, Hruban RH, Fishman EK. MDCT of intraductal papillary mucinous neoplasm of the pancreas: evaluation of features predictive of invasive carcinoma. AJR Am J Roentgenol. 2006 Mar;186(3):687–95.
Sahani DV, Saokar A, Hahn PF, Brugge WR, Fernandez-Del Castillo C. Pancreatic cysts 3 cm or smaller: how aggressive should treatment be? Radiology. 2006 Mar;238(3):912–9.
Megibow AJ, Lombardo FP, Guarise A, et al. Cystic pancreatic masses: cross-sectional imaging observations and serial follow-up. Abdom Imaging. 2001 Nov-Dec;26(6): 640–7.
Allen PJ, Jaques DP, D’Angelica M, Bowne WB, Conlon KC, Brennan MF. Cystic lesions of the pancreas: selection criteria for operative and nonoperative management in 209 patients. J Gastrointest Surg. 2003 Dec;7(8):970–7.
Duraker N, Hot S, Polat Y, Hobek A, Gencler N, Urhan N. CEA, CA 19–9, and CA 125 in the differential diagnosis of benign and malignant pancreatic diseases with or without jaundice. J Surg Oncol. 2007 Feb 1;95(2):142–7.
Goonetilleke KS, Siriwardena AK. Systematic review of carbohydrate antigen (CA 19–9) as a biochemical marker in the diagnosis of pancreatic cancer. Eur J Surg Oncol. 2006 Nov 8; [Epub ahead of print].
Albert MB, Steinberg WM, Henry JP. Elevated serum levels of tumor marker CA19–9 in acute cholangitis. Dig Dis Sci. 1988 Oct;33(10):1223–5.
Schima W, Ba-Ssalamah A, Kolblinger C, Kulinna-Cosentini C, Puespoek A, Gotzinger P. Pancreatic adenocarcinoma. Eur Radiol. 2007 Mar;17(3):638–49.
Leach SD, Lee JE, Charnsangavej C, et al. Survival following pancreaticoduodenectomy with resection of the superior mesenteric-portal vein confluence for adenocarcinoma of the pancreatic head. Br J Surg. 1998 May;85(5):611–7.
Cameron JL, Riall TS, Coleman J, Belcher KA. One thousand consecutive pancreaticoduodenectomies. Ann Surg. 2006 Jul;244(1):10–5.
Geer RJ, Brennan MF. Prognostic indicators for survival after resection of pancreatic adenocarcinoma. Am J Surg. 1993 Jan;165(1):68–72.
Lu DS, Reber HA, Krasny RM, Kadell BM, Sayre J. Local staging of pancreatic cancer: criteria for unresectability of major vessels as revealed by pancreatic-phase, thin-section helical CT. AJR Am J Roentgenol. 1997 Jun;168(6):1439–43.
O’Malley ME, Boland GW, Wood BJ, Fernandez-del Castillo C, Warshaw AL, Mueller PR. Adenocarcinoma of the head of the pancreas: determination of surgical unresectability with thin-section pancreatic-phase helical CT. AJR Am J Roentgenol. 1999 Dec;173(6):1513–8.
Li H, Zeng MS, Zhou KR, Jin DY, Lou WH. Pancreatic adenocarcinoma: the different CT criteria for peripancreatic major arterial and venous invasion. J Comput Assist Tomogr. 2005 Mar-Apr;29(2):170–5.
Li H, Zeng MS, Zhou KR, Jin DY, Lou WH. Pancreatic adenocarcinoma: signs of vascular invasion determined by multi-detector row CT. Br J Radiol. 2006 Nov;79(947):880–7.
Kalser MH, Barkin J, MacIntyre JM. Pancreatic cancer. Assessment of prognosis by clinical presentation. Cancer. 1985 Jul 15;56(2):397–402.
Vogt DP. Pancreatic cancer: a current overview. Curr Surg. 2000 May 1;57(3):214–220.
Reber HA. Small pancreatic tumors: Is size an indication of curability? J hepatobiliary Pancreat Surg 1995; 2(4): 384–386.
Spencer MP, Sarr MG, Nagorney DM. Radical pancreatectomy for pancreatic cancer in the elderly. Is it safe and justified? Ann Surg. 1990 Aug;212(2):140–3.
Farrell JJ. Diagnosing pancreatic malignancy in the setting of chronic pancreatitis: is there room for improvement? Gastrointest Endosc. 2005 Nov;62(5):737–41.
Varadarajulu S, Tamhane A, Eloubeidi MA. Yield of EUS-guided FNA of pancreatic masses in the presence or the absence of chronic pancreatitis. Gastrointest Endosc. 2005 Nov;62(5):728–36.
Volmar KE, Vollmer RT, Jowell PS, Nelson RC, Xie HB. Pancreatic FNA in 1000 cases: a comparison of imaging modalities. Gastrointest Endosc. 2005 Jun;61(7):854–61.
Horwhat JD, Paulson EK, McGrath K, et al. A randomized comparison of EUS-guided FNA versus CT or US-guided FNA for the evaluation of pancreatic mass lesions. Gastrointest Endosc. 2006 Jun;63(7):966–75.
Erturk SM, Mortele KJ, Tuncali K, Saltzman JR, Lao R, Silverman SG. Fine-needle aspiration biopsy of solid pancreatic masses: comparison of CT and endoscopic sonography guidance. AJR Am J Roentgenol. 2006 Dec;187(6):1531–5.
Micames C, Jowell PS, White R, et al. Lower frequency of peritoneal carcinomatosis in patients with pancreatic cancer diagnosed by EUS-guided FNA versus percutaneous FNA. Gastrointest Endosc. 2003 Nov;58(5):690–5.
Ichikawa T, Sou H, Araki T, et al. Duct-penetrating sign at MRCP: usefulness for differentiating inflammatory pancreatic mass from pancreatic carcinomas. Radiology. 2001 Oct;221(1):107–16.
Stefanidis D, Grove KD, Schwesinger WH, Thomas CR Jr. The current role of staging laparoscopy for adenocarcinoma of the pancreas: a review. Ann Oncol. 2006 Feb;17(2):189–99.
Fernandez-del Castillo C, Warshaw AL. Laparoscopy for staging in pancreatic carcinoma. Surg Oncol. 1993;2 Suppl 1:25–9.
Liu RC, Traverso LW. Diagnostic laparoscopy improves staging of pancreatic cancer deemed locally unresectable by computed tomography. Surg Endosc. 2005. May; 19(5):638–42.
Ichikawa T, Erturk SM, Sou H, et al. MDCT of Pancreatic Adenocarcinoma: Optimal Imaging Phases and Multiplanar Reformatted Imaging. AJR Am J Roentgenol. Dec 2006 (187): 1513–1520.
Morganti AG, Brizi MG, Macchia G, et al. The prognostic effect of clinical staging in pancreatic adenocarcinoma.Ann Surg Oncol. 2005 Feb;12(2):145–51.
Schueller G, Schima W, Schueller-Weidekamm C, et al. Multidetector CT of pancreas: effects of contrast material flow rate and individualized scan delay on enhancement of pancreas and tumor contrast. Radiology. 2006 Nov;241(2):441–8.
Prokesch RW, Chow LC, Beaulieu CF, Bammer R, Jeffrey RB Jr. Isoattenuating pancreatic adenocarcinoma at multi-detector row CT: secondary signs. Radiology. 2002 Sep;224(3): 764–8.
Semelka RC, Kelekis NL, Molina PL, Sharp TJ, Calvo B. Pancreatic masses with inconclusive findings on spiral CT: is there a role for MRI? J Magn Reson Imaging. 1996 Jul-Aug;6(4):585–8.
Raptopoulos V, Steer ML, Sheiman RG, Vrachliotis TG, Gougoutas CA, Movson JS. The use of helical CT and CT angiography to predict vascular involvement from pancreatic cancer: correlation with findings at surgery. AJR Am J Roentgenol. 1997 Apr;168(4):971–7.
Ellsmere J, Mortele K, Sahani D, et al. Does multidetector-row CT eliminate the role of diagnostic laparoscopy in assessing the resectability of pancreatic head adenocarcinoma? Surg Endosc. 2005 Mar;19(3):369–73.
Vargas R, Nino-Murcia M, Trueblood W, Jeffrey RB Jr. MDCT in Pancreatic adenocarcinoma: prediction of vascular invasion and resectability using a multiphasic technique with curved planar reformations. AJR Am J Roentgenol 2004 Feb;182(2):419–25.
Legmann P, Vignaux O, Dousset B, et al. Pancreatic tumors: comparison of dual-phase helical CT and endoscopic sonography. AJR Am J Roentgenol. 1998 May;170(5):1315–22.
Ichikawa T, Haradome H, Hachiya J, et al. Pancreatic ductal adenocarcinoma: preoperative assessment with helical CT versus dynamic MR imaging. Radiology. 1997 Mar;202(3):655–62.
Grenacher L, Klauss M, Dukic L, et al. Diagnosis and staging of pancreatic carcinoma: MRI versus multislice-CT–a prospective study. Rofo. 2004 Nov;176(11):1624–33.
DeWitt J, Devereaux B, Chriswell M, McGreevy, et al. Comparison of endoscopic ultrasonography and multidetector computed tomography for detecting and staging pancreatic cancer. Ann Intern Med. 2004 Nov 16;141(10):753–63.
Curry CA, Eng J, Horton KM, et al. CT of primary cystic pancreatic neoplasms: can CT be used for patient triage and treatment? AJR Am J Roentgenol. 2000 Jul;175(1):99–103.
Kim SY, Lee JM, Kim SH, et al. Macrocystic neoplasms of the pancreas: CT differentiation of serous oligocystic adenoma from mucinous cystadenoma and intraductal papillary mucinous tumor. AJR Am J Roentgenol. 2006 Nov;187(5):1192–8.
Kang CM, Park SH, Kim KS, Choi JS, Lee WJ, Kim BR. Surgical experiences of functioning neuroendocrine neoplasm of the pancreas. Yonsei Med J. 2006 Dec 31; 47(6):833–9.
Van Hoe L, Gryspeerdt S, Marchal G, Baert AL, Mertens L. Helical CT for the preoperative localization of islet cell tumors of the pancreas: value of arterial and parenchymal phase images. AJR Am J Roentgenol. 1995 Dec;165(6):1437–9.
Rappeport ED, Hansen CP, Kjaer A, Knigge U. Multidetector computed tomography and neuroendocrine pancreaticoduodenal tumors. Acta Radiol. 2006 Apr;47(3):248–56.
Gouya H, Vignaux O, Augui J, Dousset B, Palazzo L, Louvel A, et al. CT, endoscopic sonography, and a combined protocol for preoperative evaluation of pancreatic insulinomas. AJR Am J Roentgenol. 2003 Oct;181(4):987–92.
King CM, Reznek RH, Dacie JE, Wass JA. Imaging islet cell tumours. Clin Radiol. 1994 May;49(5):295–303.
Sodickson A, Mortele KJ, Barish MA, et al. Three-dimensional fast-recovery fast spin-echo MRCP: comparison with two-dimensional single-shot fast spin-echo techniques. Radiology. 2006; 238(2):549–59.
Hellerhoff KJ, Helmberger H 3rd, Rosch T, et al. Dynamic MR pancreatography after secretin administration: image quality and diagnostic accuracy. AJR Am J Roentgenol. 2002; 179(1):121–9.
Ichikawa T, Erturk SM, Motosugi U, et al. High-b value diffusion-weighted MRI for detecting pancreatic adenocarcinoma: preliminary results. AJR Am J Roentgenol. 2007 Feb;188(2):409–14.
Erturk SM, Ichikawa T, Sou H, et al. Pancreatic Adenocarcinoma: MDCT Versus MRI in the Detection and Assessment of Locoregional Extension. JCAT 2006; 30(4):583–590.
Holalkere NS, Sahani DV, Blake MA, Halpern EF, Hahn PF, Mueller PR. Characterization of small liver lesions: Added role of MR after MDCT. J Comput Assist Tomogr. 2006 Jul-Aug;30(4):591–6.
Schwartz LH, Gandras EJ, Colangelo SM, Ercolani MC, Panicek DM. Prevalence and importance of small hepatic lesions found at CT in patients with cancer. Radiology. 1999 Jan;210(1):71–4.
Schima W, Fugger R, Schober E, et al. Diagnosis and staging of pancreatic cancer: comparison of mangafodipir trisodium-enhanced MR imaging and contrast-enhanced helical hydro-CT. AJR Am J Roentgenol. 2002 Sep;179(3):717–24.
Dromain C, de Baere T, Lumbroso J, et al. Detection of liver metastases from endocrine tumors: a prospective comparison of somatostatin receptor scintigraphy, computed tomography, and magnetic resonance imaging. J Clin Oncol. 2005 Jan 1;23(1):70–8.
Higashi T, Saga T, Nakamoto Y, et al. Diagnosis of pancreatic cancer using fluorine-18 fluorodeoxyglucose positron emission tomography (FDG PET)–usefulness and limitations in “clinical reality”. Ann Nucl Med. 2003 Jun;17(4):261–79.
Orlando LA, Kulasingam SL, Matchar DB. Meta-analysis: the detection of pancreatic malignancy with positron emission tomography. Aliment Pharmacol Ther. 2004 Nov 15;20(10):1063–70.
Rosenbaum SJ, Stergar H, Antoch G, Veit P, Bockisch A, Kuhl H. Staging and follow-up of gastrointestinal tumors with PET/CT. Abdom Imaging. 2006 Jan-Feb;31(1):25–35
Lemke AJ, Niehues SM, Hosten N, et al. Retrospective digital image fusion of multidetector CT and 18F-FDG PET: clinical value in pancreatic lesions–a prospective study with 104 patients. J Nucl Med. 2004 Aug;45(8):1279–86.
Ruf J, Lopez Hanninen E, Bohmig M, et al. Impact of FDG-PET/MRI Image Fusion on the Detection of Pancreatic Cancer. Pancreatology. 2006 Nov 13;6(6):512–519.
Diederichs CG, Staib L, Vogel J, et al. Values and limitations of 18F-fluorodeoxyglucose-positron-emission tomography with preoperative evaluation of patients with pancreatic masses. Pancreas. 2000 Mar; 20(2):109–16.
Frohlich A, Diederichs CG, Staib L, Vogel J, Beger HG, Reske SN. Detection of liver metastases from pancreatic cancer using FDG PET. J Nucl Med. 1999 Feb;40(2):250–5.
Sahani DV, Kalva SP, Fischman AJ, et al. Detection of liver metastases from adenocarcinoma of the colon and pancreas: comparison of mangafodipir trisodium-enhanced liver MRI and whole-body FDG PET. AJR Am J Roentgenol. 2005 Jul;185(1):239–46.
Yang M, Martin DR, Karabulut N, Frick MP. Comparison of MR and PET imaging for the evaluation of liver metastases. J Magn Reson Imaging. 2003 Mar;17(3):343–9.
Yoshioka M, Sato T, Furuya T, et al. Role of positron emission tomography with 2-deoxy-2-[18F]fluoro-D-glucose in evaluating the effects of arterial infusion chemotherapy and radiotherapy on pancreatic cancer. J Gastroenterol. 2004 Jan;39(1):50–5.
Maisey NR, Webb A, Flux GD, et al. FDG-PET in the prediction of survival of patients with cancer of the pancreas: a pilot study. J Cancer. 2000 Aug;83(3):287–93.
Bang S, Chung HW, Park SW, et al. The clinical usefulness of 18-fluorodeoxyglucose positron emission tomography in the differential diagnosis, staging, and response evaluation after concurrent chemoradiotherapy for pancreatic cancer. J Clin Gastroenterol. 2006 Nov-Dec;40(10):923–9.
Rose DM, Delbeke D, Beauchamp RD, et al. 18Fluorodeoxyglucose-positron emission tomo graphy in the management of patients with suspected pancreatic cancer. Ann Surg. 1999 May;229(5):729–37.
Lyshchik A, Higashi T, Nakamoto Y, et al. Dual-phase 18F-fluoro-2-deoxy-D-glucose positron emission tomography as a prognostic parameter in patients with pancreatic cancer. Eur J Nucl Med Mol Imaging. 2005 Apr;32(4):389–97.
Nishiyama Y, Yamamoto Y, Monden T, et al. Evaluation of delayed additional FDG PET imaging in patients with pancreatic tumour. Nucl Med Commun. 2005 Oct;26(10):895–901.
Been LB, Suurmeijer AJ, Cobben DC, Jager PL, Hoekstra HJ, Elsinga PH. [18F]FLT-PET in oncology: current status and opportunities. Eur J Nucl Med Mol Imaging. 2004 Dec;31(12):1659–72.
van Waarde A, Jager PL, Ishiwata K, Dierckx RA, Elsinga PH. Comparison of sigma-ligands and metabolic PET tracers for differentiating tumor from inflammation. J Nucl Med. 2006 Jan;47(1):150–4.
Mansour JC, Schwartz L, Pandit-Taskar N, et al. The utility of F-18 fluorodeoxyglucose whole body PET imaging for determining malignancy in cystic lesions of the pancreas. J Gastrointest Surg. 2006 Dec;10(10):1354–60.
Cronan JJ. Ultrasound: Is there a future in diagnostic imaging? JACR 2006; 3(9): 645–6.
Rickes S, Monkemuller K, Malfertheiner P. Contrast-enhanced ultrasound in the diagnosis of pancreatic tumors. JOP. 2006 Nov 10;7(6):584–92.
Korpanty G, Carbon JG, Grayburn PA, Fleming JB, Brekken RA. Monitoring response to anticancer therapy by targeting microbubbles to tumor vasculature. Clin Cancer Res. 2007 Jan 1;13(1):323–30.
Calculli L, Pezzilli R, Casadei R, Fiscaletti, et al. The imaging of pancreatic exocrine solid tumors: the role of computed tomography and positron emission tomography. JOP. 2007 Jan 9;8(1 Suppl):77–84.
Dewitt J, Devereaux BM, Lehman GA, Sherman S, Imperiale TF. Comparison of endoscopic ultrasound and computed tomography for the preoperative evaluation of pancreatic cancer: a systematic review. Clin Gastroenterol Hepatol. 2006 Jun;4(6):717–25.
Klapman JB, Chang KJ, Lee JG, Nguyen P. Negative predictive value of endoscopic ultrasound in a large series of patients with a clinical suspicion of pancreatic cancer. Am J Gastroenterol. 2005 Dec;100(12):2658–61.
Alsibai KD, Denis B, Bottlaender J, Kleinclaus I, Straub P, Fabre M. Impact of cytopathologist expert on diagnosis and treatment of pancreatic lesions in current clinical practice. A series of 106 endoscopic ultrasound-guided fine needle aspirations. Cytopathology. 2006 Feb;17(1):18–26.
De Angelis C, Repici A, Carucci P, et al. Pancreatic cancer imaging: the new role of endoscopic ultrasound. JOP. 2007 Jan 9;8(1 Suppl):85–97.
Micames CG, Gress FG. Local EUS-guided injection of chemotherapeutic agents as adjuvant to systemic treatment: the first steps are made. Gastrointest Endosc. 2006 Dec 13; [Epub ahead of print].
Tran QN, Urayama S, Meyers FJ. Endoscopic ultrasound-guided celiac plexus neurolysis for pancreatic cancer pain: a single-institution experience and review of the literature. J Support Oncol. 2006 Oct;4(9):460–2, 464; discussion 463–4.
Wang PJ, Shang MY, Qian Z, Shao CW, Wang JH, Zhao XH. CT-guided percutaneous neurolytic celiac plexus block technique. Abdom Imaging. 2006 Dec 7; [Epub ahead of print].
Anderson MA, Carpenter S, Thompson NW, Nostrant TT, Elta GH, Scheiman JM. Endoscopic ultrasound is highly accurate and directs management in patients with neuroendocrine tumors of the pancreas. Am J Gastroenterol. 2000 Sep;95(9):2271–7.
Kwon RS, Scheiman JM. New advances in pancreatic imaging. Curr Opin Gastroenterol. 2006 Sep;22(5):512–9.
Fujita N, Noda Y, Kobayashi G, Kimura K, Ito K. Endoscopic approach to early diagnosis of pancreatic cancer. Pancreas. 2004 Apr;28(3):279–81.
Furukawa T, Tsukamoto Y, Naitoh Y, Hirooka Y, Hayakawa T. Differential diagnosis between benign and malignant localized stenosis of the main pancreatic duct by intraductal ultrasound of the pancreas. Am J Gastroenterol. 1994 Nov;89(11):2038–41.
Furukawa T, Oohashi K, Yamao K, et al. Intraductal ultrasonography of the pancreas: development and clinical potential. Endoscopy. 1997 Aug;29(6):561–9.
Testoni PA, Mariani A, Mangiavillano B, et al. Main pancreatic duct, common bile duct and sphincter of Oddi structure visualized by optical coherence tomography: An ex vivo study compared with histology. Dig Liver Dis. 2006 Jun;38(6):409–14.
Testoni PA, Mangiavillano B, Albarello L, et al. Optical coherence tomography to detect epithelial lesions of the main pancreatic duct: an Ex Vivo study. Am J Gastroenterol. 2005 Dec;100(12):2777–83.
Testoni PA, Mariani A, Mangiavillano B, Arcidiacono PG, Masci E. Preliminary data on the use of intraductal optical coherence tomography during ERCP for investigating main pancreatic duct strictures. Gut. 2006 Nov;55(11):1680–1.
Testoni PA, Mariani A, Mangiavillano B, Arcidiacono PG, Di Pietro S, Masci E. Intraductal Optical Coherence Tomography for Investigating Main Pancreatic Duct Strictures. Am J Gastroenterol 2007;102:269–274.
Roach PJ, Schembri GP, Ho Shon IA, Bailey EA, Bailey DL. SPECT/CT imaging using a spiral CT scanner for anatomical localization: Impact on diagnostic accuracy and reporter confidence in clinical practice. Nucl Med Commun. 2006 Dec;27(12):977–87.
Ingui CJ, Shah NP, Oates ME. Endocrine neoplasm scintigraphy: added value of fusing SPECT/CT images compared with traditional side-by-side analysis. Clin Nucl Med. 2006 Nov;31(11):665–72.
Stabile BE, Morrow DJ, Passaro E Jr. The gastrinoma triangle: operative implications. Am J Surg. 1984 Jan;147(1):25–31.
Gibril F, Reynolds JC, Doppman JL, et al. Somatostatin receptor scintigraphy: its sensitivity compared with that of other imaging methods in detecting primary and metastatic gastrinomas. A prospective study. Ann Intern Med. 1996 Jul 1;125(1):26–34.
Montet X, Weissleder R, Josephson L. Imaging pancreatic cancer with a peptide-nanoparticle conjugate targeted to normal pancreas. Bioconjug Chem. 2006 Jul-Aug;17(4):905–11.
Fleischmann A, Laderach U, Friess H, Buechler MW, Reubi JC. Bombesin receptors in distinct tissue compartments of human pancreatic diseases. Lab Invest 2000. Dec;80(12):1807–17.
Rehman S, Jayson GC. Molecular imaging of antiangiogenic agents. Oncologist. 2005 Feb;10(2):92–103.
Miles KA, Hayball MP, Dixon AK. Measurement of human pancreatic perfusion using dynamic computed tomography with perfusion imaging. Br J Radiol. 1995 May;68(809):471–5.
Xue HD, Jin ZY, Liu W, Wang Y, Zhao WM. Perfusion characteristics of normal pancreas and insulinoma on multi-slice spiral CT. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2006 Feb;28(1):68–70.
Kiessling F, Morgenstern B, Zhang C. Contrast agents and applications to assess tumor angiogenesis in vivo by magnetic resonance imaging. Curr Med Chem. 2007;14(1):77–91.
Johnson PT, Outwater EK. Pancreatic carcinoma versus chronic pancreatitis: dynamic MR imaging. Radiology. 1999 Jul. 212(1):213–8.
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Rabinowitz, C.B., Prabhakar, H.B., Sahani, D.V. (2008). Recent Advances in Imaging of Pancreatic Neoplasms. In: Blake, M.A., Kalra, M.K. (eds) Imaging in Oncology. Cancer Treatment and Research, vol 143. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-75587-8_9
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