Adrenal masses are relatively common in the general population, with a mean prevalence determined from several large autopsy studies of 2.3 percent [1]. Given the propensity for and the clinical importance of adrenal metastatic involvement, accurate diagnosis of adrenal masses is of particular important in oncologic patients. Fortunately non-invasive radiology can usually determine whether a mass is benign or likely malignant (indeterminate lesion), based on recent research into the imaging characteristics of adrenal masses.
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References
Barzon L, Sonino N, Fallo F, Palu G, Boscaro M. Prevalence and natural history of adrenal incidentalomas. Eur J Endocrinol 2003; 149:273–85.
Blake MA, Kalra MK, Sweeney AT, et al. Distinguishing benign from malignant adrenal masses: multi-detector row CT protocol with 10-minute delay. Radiology 2006:578–585.
Szolar DH, Korobkin M, Reittner P, et al. Adrenocortical carcinomas and adrenal pheochromocytomas: mass and enhancement loss evaluation at delayed contrast-enhanced CT. Radiology 2005; 234:479–85.
Caoili EM, Korobkin M, Francis IR, et al. Adrenal masses: characterization with combined unenhanced and delayed enhanced CT. Radiology 2002; 222:629–33.
Lee M, Hahn P, Papanicolaou N, et al. Benign and malignant adrenal masses: CT distinction with attenuation coefficients, size, and observer analysis. Radiology 1991; 179:415–8.
Korobkin M, Brodeur FJ, Yutzy GG, et al. Differentiation of adrenal adenomas from nonadenomas using CT attenuation values. AJR Am J Roentgenol 1996; 166:531–6.
Singer A, Obuchowski N, Einstein D, Paushter D. Metastasis or adenoma? Computed tomographic evaluation of the adrenal mass. Cleve Clin J Med 1994; 61:200–5.
van Erkel A, van Gils A, Lequin M, Kruitwagen C, Bloem J, Falke T. CT and MR distinction of adenomas and nonadenomas of the adrenal gland. J Comput Assist Tomogr 1994; 18:432–8.
Boland GW, Lee MJ, Gazelle GS, Halpern EF, McNicholas MM, Mueller PR. Characterization of adrenal masses using unenhanced CT: an analysis of the CT literature. AJR Am J Roentgenol 1998; 171:201–4.
Choyke P. ACR Appropriateness Criteria on Incidentally Discovered Adrenal Masses. J Am Coll Radiol 2006; 3:498–504.
Korobkin MF, Brodeur FJ, Francis IR, Quint LE, Dunnick NR, Goodsitt M. Delayed enhanced CT for differentiation of benign from malignant adrenal masses. Radiology 1996; 200:737–42.
Korobkin MF, Brodeur FJ, Francis IR, Quint LE, Dunnick NR, Londy F. CT time-attenuation washout curves of adrenal adenomas and nonadenomas. AJR Am J Roentgenol 1998; 170: 747–52.
Blake MA, Krishnamoorthy SK, Boland GW, et al. Low-density pheochromocytoma on CT: a mimicker of adrenal adenoma. AJR Am J Roentgenol 2003; 181:1663–8.
Jain RK, Munn LL, Fukumura D. Dissecting tumor pathophysiology using intravital microscopy. Nat Rev Cancer 2002; 2:266–76.
Boland GW, Hahn PF, Pena C, Mueller PR. Adrenal masses: characterization with delayed contrast-enhanced CT. Radiology 1997; 202:693–6.
Caoili EM, Korobkin M, Francis IR, Cohan RH, Dunnick NR. Delayed enhanced CT of lipid-poor adrenal adenomas. AJR Am J Roentgenol 2000; 175:1411–5.
Pena CS, Boland GW, Hahn PF, Lee MJ, Mueller PR. Characterization of indeterminate (lipid-poor) adrenal masses: use of washout characteristics at contrast-enhanced CT. Radiology 2000; 217:798–802.
Young WF. The incidentally discovered adrenal mass. N Eng J Med 2007; 356:601–10.
Bae KT, Fuangtharnthip P, Prasad SR, Joe BN, Heiken JP. Adrenal masses: CT characterization with histogram analysis method. Radiology 2003; 228:735–42.
Remer EM, Motta-Ramirez GA, Shepardson LB, Hamrahian AH, Herts BR. CT histogram analysis in pathologically proven adrenal masses. AJR Am J Roentgenol 2006; 187:191–6.
Blake MA, Kalra MK, Maher MM, et al. Pheochromocytoma: an imaging chameleon. Radiographics 2004; 24:S87–99.
Israel GM, Korobkin M, Wang C, Hecht EN, Krinsky GA. Comparison of unenhanced CT and chemical shift MRI in evaluating lipid-rich adrenal adenomas. AJR Am J Roentgenol 2004; 183:215–9.
Mayo-Smith WW, Boland GW, Noto RB, Lee MJ. State-of-the-art adrenal imaging. Radiographics 2001; 21:995–1012.
Haider MA, Ghai S, Jhaveri K, Lockwood G. Chemical shift MR imaging of hyperattenuating (>10 HU) adrenal masses: does it still have a role? Radiology 2004; 231:711–716.
Boland GW, Goldberg MA, Lee MJ, et al. Indeterminate adrenal mass in patients with cancer: evaluation at PET with 2-[F-18]-fluoro-2-deoxy-D-glucose. Radiology 1995; 194:131–4.
Blake MA, Slattery JM, Kalra MK, et al. Adrenal lesions: characterization with fused PET/CT image in patients with proved or suspected malignancy–initial experience. Radiology 2006; 238:970–7.
Kumar R, Xiu Y, Yu JQ, et al. 18F-FDG PET in evaluation of adrenal lesions in patients with lung cancer. J Nucl Med 2004; 45:2058–62.
Metser U, Miller E, Lerman H, Lievshitz G, Avital S, Even-Sapir E. 18F-FDG PET/CT in the Evaluation of Adrenal Masses. J Nucl Med 2006; 47:32–37.
Erasmus JJ, Patz EF, Jr., McAdams HP, et al. Evaluation of adrenal masses in patients with bronchogenic carcinoma using 18F-fluorodeoxyglucose positron emission tomography. AJR Am J Roentgenol 1997; 168:1357–60.
Minn H, Salonen A, Friberg J, et al. Imaging of adrenal incidentalomas with PET using (11) C-metomidate and (18) F-FDG. J Nucl Med 2004; 45:972–9.
Mansmann G, Lau J, Balk E, Rothberg M, Miyachi Y, Bornstein SR. The clinically inapparent adrenal mass: update in diagnosis and. Endocr Rev 2004; 25:309–40.
Grumbach MM, Biller BM, Braunstein GD, et al. Management of the clinically inapparent adrenal mass (“incidentaloma”). Ann Intern Med 2003; 138:424–9.
Schteingart DE, Doherty GM, Gauger PG, et al. Management of patients with adrenal cancer: recommendations of an international consensus conference. Endocr Relat Cancer 2005; 12:667–80.
Stone J. Incidentalomas–clinical correlation and translational science required. N Engl J Med 2006; 354:2748–9.
Blake MA, Sweeney AT, Kalra MK, Maher M. Collision Adrenal Tumors on PET/CT. Am J Roentgenol. 183(3):864–5, 2004.
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Blake, M.A., Kalra, M.K. (2008). Current Status of Imaging for Adrenal Malignant Involvement. In: Blake, M.A., Kalra, M.K. (eds) Imaging in Oncology. Cancer Treatment and Research, vol 143. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-75587-8_13
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