Abstract
An artificial genome with biologically plausible properties was developed and the dynamics of gene expression were studied. The model differs from previous approaches, such as Random Boolean Nets [1], in that it is entirely based on template matching in a nucleotide-like sequence. Genes activate or inhibit other genes by binding to their regulatory sequences.
The results of the experiments suggest that many features of real-life development, such as cyclic gene activity, differentiation into multiple cell types, and robusteness may be inherent properties of a template-matching system rather than necessarily designed from scratch by Natural Selection. Moreover, the system may provide a new hypothesis about the role of junk DNA in real genomes. In addition to these biological implications, the approach used here is thought to provide a flexible basis for future simulations of morphogenesis.
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References
Kauffman, S.A.: Gene regulation networks: A theory for their global structure and behavior. Current Topics in Dev. Biol. 6 (1971): 145.
Mewes, H.W., Albermann, K., Bahr, M. Frishman, D., Gleissner, A., Hani, J., Heumann, K., Kleine, K., Maierl, A., Oliver, S.G., Pfeiffer, F., Zollner, A.: Overview of the yeast genome. Nature 387 (1997): 7–8.
Wilson, R.K.: How the worm was won-the C. elegans genome sequencing project. Trends in Genetics 15 (1999): 51–58.
Gilbert, S.: Developmental Biology. Sinauer Associates (1994)
Kauffman, S.A.: The large-scale structure and dynamics of gene control circuits: An ensemble approach. J. Theoret. Bio. 44 (1974): 167.
Maynard Smith, J.: Shaping Life — Genes, Embryos and Evolution. Weidenfeld and Nicolson (1998).
Alberts, B., Bray, D., Lewis, J., Raff, M., Roberts, K., Watson, J.: Molecular Biology of the Cell. Garland Publishing Inc. (1994).
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© 1999 Springer-Verlag Berlin Heidelberg
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Reil, T. (1999). Dynamics of Gene Expression in an Artificial Genome — Implications for Biological and Artificial Ontogeny. In: Floreano, D., Nicoud, JD., Mondada, F. (eds) Advances in Artificial Life. ECAL 1999. Lecture Notes in Computer Science(), vol 1674. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-48304-7_63
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DOI: https://doi.org/10.1007/3-540-48304-7_63
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-66452-9
Online ISBN: 978-3-540-48304-5
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