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Noise in Molecular Systems

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Nonlinear Science at the Dawn of the 21st Century

Part of the book series: Lecture Notes in Physics ((LNP,volume 542))

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Abstract

Molecular and macromolecular systems in contact with fluctuating environments close to equilibrium present several interesting transport features. We will focus on simple systems constituted of particles in periodic non-symmetric potentials under the influence of non-equilibrium noise. The resulting ratchet or motor motion is manifested through nonzero persistent particle currents. These model systems are not dissimilar to motor proteins executing directed motion on cytoskeletal filaments.

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References

  1. F. Julicher, A. Ajdari and J. Prost, Modeling molecular motors, Rev. Mod. Phys. 69, 1269 (1997) and references therein.

    Article  ADS  Google Scholar 

  2. R. D. Astumian, Thermodynamics and Kinetics of a Brownian Motor, Science 276, 917 (1997), ans references therein.

    Article  Google Scholar 

  3. T. E. Dialynas and G. P. Tsironis, Phys.Lett.A 218, 292 (1996).

    Article  ADS  Google Scholar 

  4. I. Derényi and T. Vicsek, Proc. Natl. Acad. Sci. USA 93, 6775–6779 (1996).

    Article  ADS  Google Scholar 

  5. A. Savin, G. P. Tsironis and A. V. Zolotaryuk, Phys. Lett. A, 229, 279 (1997).

    Article  ADS  Google Scholar 

  6. K. Svoboda et al., Direct observation of kinesin stepping by optical trapping interferometry, Nature 365 721–727 (1993).

    Article  ADS  Google Scholar 

  7. K. Svoboda and S. M. Block, Force and velocity measured for single kinesin molecules, Cell 77, 773–784 (1994).

    Article  Google Scholar 

  8. K. Svoboda, P. P. Mitra and S. M. Block, Fluctuation analysis of motor protein movement and single enzyme kinetics, Proc. Natl. Acad. Sci. USA 91, 11782–11786 (1994).

    Google Scholar 

  9. R. D. Vale et al., Direct observation of single kinesin molecules moving along microtubules, Nature 380, 451–453 (1996).

    Article  ADS  Google Scholar 

  10. C. M. Coppin et al., Detection of sub-8-nm movements of kinesin by highresolution optical-trap microscopy, Proc. Natl. Acad. Sci. USA 93, 1913–1917 (1996).

    Google Scholar 

  11. J. Howard, The movement of kinesin along microtubules, An. Rev. Physiol. 58, 703–729 (1996).

    Article  Google Scholar 

  12. R. B. Case, D. W. Pierce, N. Hom-Booher, C. L. Hart and R. D. Vale, The directional preference of kinesin motors is specified by an element outside of the motor catalytic domain, Cell 90, 959 (1997).

    Article  Google Scholar 

  13. U. Henningsen and M. Schliwa, Reversal in the direction of movement of a molecular motor, Nature 389, 93–95 (1997).

    Article  ADS  Google Scholar 

  14. W. Hua et al., Coupling of kinesin steps to ATP hydrolysis, Nature 388, 390–393 (1997).

    Article  ADS  Google Scholar 

  15. M. J. Schnitzer and S. M. Block, Kinesin hydrolyses one ATP per 8-nm step, Nature 388, 386–390 (1997).

    Article  ADS  Google Scholar 

  16. H. Sosa et al., A model for the Microtubule-Ncd Motor Protein Complex Obtained by Cryo-Electron Microscopy and Image Analysis, Cell 90, 217–224 (1997).

    Article  Google Scholar 

  17. B. Tipet, R. D. Vale and R. S. Hodges, Demonstration of coiled-coil interactions within the kinesin neck region using synthetic peptides, J. Biol. Chem. 272, 8946–8956 (1997).

    Article  Google Scholar 

  18. C. Tucker and L. S. B. Goldstein, Probing the kinesin-microtubule interaction, J. Biol. Chem. 272, 9481–9488 (1997).

    Article  Google Scholar 

  19. T. E. Dialynas, K. Lindenberg and G.P. Tsironis, Phys. Rev. E 56, 3976–3985 (1997).

    Article  ADS  Google Scholar 

  20. G. P. Tsironis and Katja Lindenberg, Motor proteins have highly correlated Brownian engines, eds. S. K. Malhotra and J. A. Tuszynski. in Advances in Structural Biology vol.5, Academic Press, (Stamford 1998).

    Google Scholar 

  21. K. Lindenberg and B. J. West, The Nonequilibrium Statistical Mechanics of Open and Closed Systems (VCH Publishers, New York, 1990).

    MATH  Google Scholar 

  22. G. Stratopoulos, T. Dialynas and G. P. Tsironis, Directional Newtonian Motion and Reversals of Molecular Motors, Phys. Lett. A 252, 151 (1999).

    Article  ADS  Google Scholar 

  23. H. Frauenfelder, P. G. Wolynes and R. H. Austin, Biological Physics, Rev. Mod. Phys. 71, S419 (1999).

    Article  Google Scholar 

  24. A. Aubry and G.P. Tsironis, unpublished.

    Google Scholar 

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© 2000 Springer-Verlag Berlin Heidelberg

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Tsironis, G.P. (2000). Noise in Molecular Systems. In: Christiansen, P.L., Sørensen, M.P., Scott, A.C. (eds) Nonlinear Science at the Dawn of the 21st Century. Lecture Notes in Physics, vol 542. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-46629-0_18

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  • DOI: https://doi.org/10.1007/3-540-46629-0_18

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-66918-0

  • Online ISBN: 978-3-540-46629-1

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