8.10 Conclusion
Transitional cell carcinoma is a common urological malignancy and in up to 5% of cases occurs in the kidney. The multicentric nature of TCC makes assessment of the entire urothelium essential prior to treatment. Vigilant urological and radiological follow-up is also warranted post-treatment to assess for metachronous lesions and recurrence. Conventional imaging modalities, such as IVU, RP, and US, still play a pivotal role in the assessment of hematuria in conjunction with endourological techniques. The recent advent of minimally invasive surgery that allows renal preservation makes accurate staging, usually with CT or MR imaging, mandatory to determine appropriate therapy. The technique of CTU has recently developed and offers superior detection of urinary tract tumors and calculi, as well as the ability to assess perirenal tissues and stage lesions, as a single comprehensive study. In the future, it is probable that CTU will become the standard investigation in the initial assessment and follow-up of patients with suspected TCC. Similar MR imaging protocols can also be used in patients not suitable for CTU, although detection of calculi may be suboptimal.
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References
Barentsz JO, Jager GJ, Witjes JA, Ruijs JH (1996) Primary staging of urinary bladder carcinoma: the role of MRI and a comparison with CT. Eur Radiol 6:129–133
Buckley JA, Urban BA, Soyer P, Scherrer A, Fishman EK (1996) Transitional cell carcinoma of the renal pelvis: a retrospective look at CT staging with pathologic correlation. Radiology 201:194–198
Caoili EM, Cohan RH, Korobkin M, Platt JF, Francis IR, Faerber GJ, Montie JE, Ellis JH (2002) Urinary tract abnormalities: initial experience with multi-detector row CT urography. Radiology 222:353–360
Chan V, Pantanowitz L, Vrachliotis TG, Rabkin DJ (2002) CT demonstration of a rapidly growing transitional cell carcinoma of the ureter and renal pelvis. Abdom Imaging 27:222–223
Chen GL, Bagley DH (2000) Ureteroscopic management of upper tract transitional cell carcinoma in patients with normal contralateral kidneys. J Urol 164:1173–1176
Cholankeril JV, Freundlich R, Ketyer S, Spirito AL, Napolitano J (1986) Computed tomography in urothelial tumors of renal pelvis and related filling defects. J Comput Tomogr 10:263–272
Corrie D, Thompson IM (1987) The value of retrograde pyelography for fractionally visualized upper tracts on excretory urography in the evaluation of hematuria. J Urol 138:554–556
Elliott DS, Segura JW, Lightner D, Patterson DE, Blute ML (2001) Is nephroureterectomy necessary in all cases of upper tract transitional cell carcinoma? Long-term results of conservative endourologic management of upper tract transitional cell carcinoma in individuals with a normal contralateral kidney. Urology 58:174–178
Fielding JR, Silverman SG, Rubin GD (1999) Helical CT of the urinary tract. Am J Roentgenol 172:1199–1206
Garant M, Bonaldi VM, Taourel P, Pinsky MF, Bret PM (1998) Enhancement patterns of renal masses during multiphase helical CT acquisitions. Abdom Imaging 23:431–436
Gray Sears CL, Ward JF, Sears ST, Puckett MF, Kane CJ, Amling CL (2002) Prospective comparison of computerized tomography and excretory urography in the initial evaluation of asymptomatic microhematuria. J Urol 168:2457–2460
Grossfeld GD, Litwin MS, Wolf JS, Hricak H, Shuler CL, Agerter DC, Carroll PR (2001) Evaluation of asymptomatic microscopic hematuria in adults: the American Urological Association best practice policy, part I: definition, detection, prevalence, and etiology. Urology 57:599–603
Hadas-Halpern I, Farkas A, Patlas M, Zaghal I, Sabag-Gottschalk S, Fisher D (1999) Sonographic diagnosis of ureteral tumors. J Ultrasound Med 18:639–645
Hall MC, Womack S, Sagalowsky AI, Carmody T, Erickstad MD, Roehrborn CG (1998) Prognostic factors, recurrence, and survival in transitional cell carcinoma of the upper urinary tract: a 30-year experience in 252 patients. Urology 52:594–601
Herranz-Amo F, Diez-Cordero JM, Verdu-Tartajo F, Bueno-Chomon G, Leal-Hernandez F, Bielsa-Carrillo A (1999) Need for intravenous urography in patients with primary transitional carcinoma of the bladder? Eur Urol 36:221–224
Hession P, Flynn P, Paul N, Goodfellow J, Murthy LN (1999) Intravenous urography in urinary tract surveillance in carcinoma of the bladder. Clin Radiol 54:465–467
Joffe SA, Servaes S, Okon S, Horowitz M (2003) Multi-detector row CT urography in the evaluation of hematuria. Radiographics 23:1441–1446
Kawashima A, Glockner JF, King BF Jr (2003) CT urography and MR urography. Radiol Clin North Am 41:945–961
Keeley FX, Kulp DA, Bibbo M, McCue PA, Bagley DH (1997) Diagnostic accuracy of ureteroscopic biopsy in upper tract transitional cell carcinoma. J Urol 157:33–37
Keeley FX Jr, Bibbo M, Bagley DH (1997) Ureteroscopic treatment and surveillance of upper urinary tract transitional cell carcinoma. J Urol 157:1560–1565
Kim JK, Cho KS (2003) Pictorial review: CT urography and virtual endoscopy: promising imaging modalities for urinary tract evaluation. Br J Radiol 76:199–209
Kirkali Z, Tuzel E (2003) Transitional cell carcinoma of the ureter and renal pelvis. Crit Rev Oncol Hematol 47:155–169
Kreft BP, Muller-Miny H, Sommer T, Steudel A, Vahlensieck M, Novak D, Muller BG, Schild HH (1997) Diagnostic value of MR imaging in comparison to CT in the detection and differential diagnosis of renal masses: ROC analysis. Eur Radiol 7:542–547
Lang EK, Macchia RJ, Thomas R, Watson RA, Marberger M, Lechner G, Gayle B, Richter F (2003) Improved detection of renal pathologic features on multiphasic helical CT compared with IVU in patients presenting with microscopic hematuria. Urology 61:528–532
Lee TY, Ko SF, Wan YL, Cheng YF, Yang WC, Hsieh HH, Chen WJ, Eng HL (1997) Unusual imaging presentations in renal transitional cell carcinoma. Acta Radiol 38:1015–1019
Maher MM, Kalra MK, Rizzo S, Mueller PR, Saini S (2004) Multidetector CT urography in imaging of the urinary tract in patients with hematuria. Korean J Radiol 5:1–10
McCarthy CL, Cowan NC (2002) Multidetector CT urography (MD-CTU) for urothelial imaging (Abstract). Radiology 225 (Suppl):237
McCoy JG, Honda H, Reznicek M, Williams RD (1991) Computerized tomography for detection and staging of localized and pathologically defined upper tract urothelial tumors. J Urol 146:1500–1503
McNicholas MM, Raptopoulos VD, Schwartz RK, Sheiman RG, Zormpala A, Prassopoulos PK, Ernst RD, Pearlman JD (1998) Excretory phase CT urography for opacification of the urinary collecting system. Am J Roentgenol 170:1261–1267
Milestone B, Friedman AC, Seidmon EJ, Radecki PD, Lev-Toaff AS, Caroline DF (1990) Staging of ureteral transitional cell carcinoma by CT and MRI. Urology 36:346–349
Newhouse JH, Amis ES Jr, Bigongiari LR, Bluth EI, Bush WH Jr, Choyke PL, Fritzsche P, Holder L, Sandler CM, Segal AJ, Resnick MI, Rutsky EA (2000) Radiologic investigation of patients with hematuria. American College of Radiology. ACR Appropriateness Criteria. Radiology 215 (Suppl):687–691
O’Malley ME, Hahn PF, Yoder IC, Gazelle GS, McGovern FJ, Mueller PR (2003) Comparison of excretory phase, helical computed tomography with intravenous urography in patients with painless haematuria. Clin Radiol 58:294–300
Perlman ES, Rosenfield AT, Wexler JS, Glickman MG (1996) CT urography in the evaluation of urinary tract disease. J Comput Assist Tomogr 20:620–626
Pretorius ES, Wickstrom ML, Siegelman ES (2000) MR imaging of renal neoplasms. Magn Reson Imaging Clin N Am 8:813–836
Rothpearl A, Frager D, Subramanian A, Bashist B, Baer J, Kay C, Cooke K, Raia C (1995) MR urography: technique and application. Radiology 194:125–130
Scolieri MJ, Paik ML, Brown SL, Resnick MI (2000) Limitations of computed tomography in the preoperative staging of upper tract urothelial carcinoma. Urology 56:930–934
Silverman SG, Lee BY, Seltzer SE, Bloom DA, Corless CL, Adams DF (1994) Small (≤3 cm) renal masses: correlation of spiral CT features and pathologic findings. Am J Roentgenol 163:597–605
Szolar DH, Kammerhuber F, Altziebler S, Tillich M, Breinl E, Fotter R, Schreyer HH (1997) Multiphasic helical CT of the kidney: increased conspicuity for detection and characterization of small (>3 cm) renal masses. Radiology 202:211–217
Tawfiek ER, Bagley DH (1997) Upper-tract transitional cell carcinoma. Urology 50:321–329
Urban BA, Buckley J, Soyer P, Scherrer A, Fishman EK (1997a) CT appearance of transitional cell carcinoma of the renal pelvis. Part 1. Early-stage disease. Am J Roentgenol 169:157–161
Urban BA, Buckley J, Soyer P, Scherrer A, Fishman EK (1997b) CT appearance of transitional cell carcinoma of the renal pelvis. Part 2. Advanced-stage disease. Am J Roentgenol 169:163–168
Walter C, Kruessell M, Gindele A, Brochhagen HG, Gossmann A, Landwehr P (2003) Imaging of renal lesions: evaluation of fast MRI and helical CT. Br J Radiol 76:696–703
Warshauer DM, McCarthy SM, Street L, Bookbinder MJ, Glickman MG, Richter J, Hammers L, Taylor C, Rosenfield AT (1988) Detection of renal masses: sensitivities and specificities of excretory urography/linear tomography, US, and CT. Radiology 169:363–365
Weeks SM, Brown ED, Brown JJ, Adamis MK, Eisenberg LB, Semelka RC (1995) Transitional cell carcinoma of the upper urinary tract: staging by MRI. Abdom Imaging 20:365–367
Wong-You-Cheong JJ, Wagner BJ, Davis CJ Jr (1998) Transitional cell carcinoma of the urinary tract: radiologic-pathologic correlation. Radiographics 18:123–142; quiz 148
Yousem DM, Gatewood OM, Goldman SM, Marshall FF (1988) Synchronous and metachronous transitional cell carcinoma of the urinary tract: prevalence, incidence, and radiographic detection. Radiology 167:613–618
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Browne, R.F., Torreggiani, W.C. (2006). Transitional Cell Carcinoma. In: Guermazi, A. (eds) Imaging of Kidney Cancer. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-30003-1_8
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