Access provided by Autonomous University of Puebla. Download to read the full chapter text
Chapter PDF
Keywords
- Thyroid Cancer
- Thyroid Carcinoma
- Papillary Thyroid Carcinoma
- Differentiate Thyroid Cancer
- Differentiate Thyroid Carcinoma
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
References
Ashcraft MW, Herle AJ van (1981) The comparative value of serum thyroglobulin measurements and iodine 131 total body scans in the follow-up study of patients with treated differentiated thyroid cancer. Am J Med 71:806–814
Bachelot A, Cailleux AF, Klain M, Baudin E, Ricard M, Bellon N, Caillou B, Travagli JP, Schlumberger M (2002) Relationship between tumor burden and serum thyroglobulin level in patients with papillary and follicular thyroid carcinoma. Thyroid 12:707–711
Baskin HJ, Atwood TM, Holcomb LP (2000) Recombinant and human thyrotropin stimulation in the follow-up of patients with stage I or II differentiated thyroid carcinoma. Endocr Pract 6:430–434
Bayer MF, Kriss JP (1979) Immunoradiometric assay for serum thyroglobulin: semiquantitative measurement of thyroglobulin in antithyroglobulin-positive sera. J Clin Endocrinol Metab 49:557–564
Bellantone R, Lombardi CP, Bossola M, Ferrante A, Princi P, Boscherini M, Maussier L, Salvatori M, Rufini V, Reale F, Romano L, Tallini G, Zelano G, Pontecorvi A (2001) Validity of thyroglobulin mRNA assay in peripheral blood of postoperative thyroid carcinoma patients in predicting tumor recurrences varies according to the histologic type: results of a prospective study. Cancer 92:2273–2279
Benvenga S, Burek CL, Talor M, Rose NR, Trimarchi F (2002) Heterogeneity of the thyroglobulin epitopes associated with circulating thyroid hormone autoantibodies in Hashimoto's thyroiditis and non-autoimmune thyroid diseases. J Endocrinol Invest 25:977–982
Berding G, Hüfner M, Georgi P (1992) Thyroglobulin, 131I whole body scintigraphy and risk factors in the follow-up of differentiated thyroid cancer. Nuklearmedizin 31:32–37
Black EG, Sheppard MC, Hoffenberg R (1987) Serial serum thyroglobulin measurements in the management of differentiated thyroid carcinoma. Clin Endocrinol (Oxf) 27:115–120
Botsch H, Glatz J, Schulz E, Wenzel KW (1983) Long-term follow-up using serial serum thyroglobulin determinations in patients with differentiated thyroid carcinoma. Cancer 52:1856–1859
Bourrel F, Hoff M, Regis H, Courriere P, Caron P (1998) Immunoradiometric assay of thyroglobulin in patients with differentiated thyroid carcinomas: need for thyroglobulin recovery tests. Clin Chem Lab Med 36:725–730
Chung JK, Park YJ, Kim TY, So Y, Kim SK, Park DJ, Lee DS, Lee MC, Cho BY (2002) Clinical significance of elevated level of serum antithyroglobulin antibody in patients with differentiated thyroid cancer after thyroid ablation. Clin Endocrinol (Oxf) 57:215–221
Colacchio TA, LoGerfo P, Colacchio DA, Feind C (1982) Radioiodine total body scan versus serum thyroglobulin levels in follow-up of patients with thyroid cancer. Surgery 91:42–45
Ditkoff BA, Marvin MR, Yemul S, Shi YJ, Chabot J, Feind C, Lo Gerfo PL (1996) Detection of circulating thyroid cells in peripheral blood. Surgery 120:959–964
Do Rosario PW, Fagundes TA, Maia FF, Franco AC, Figueiredo MB, Purisch S (2004) Sonography in the diagnosis of cervical recurrence in patients with differentiated thyroid carcinoma. J Ultrasound Med 23:915–920
Dow KH, Ferrell BR, Anello C (1997) Quality-of-life changes in patients with thyroid cancer after withdrawal of thyroid hormone therapy. Thyroid 7:613–619
Dralle H, Schwarzrock R, Lang W, Bocker W, Ziegler H, Schroder S, Geerlings H (1985) Comparison of histology and immunohistochemistry with thyroglobulin serum levels and radioiodine uptake in recurrences and metastases of differentiated thyroid carcinomas. Acta Endocrinol (Copenh) 108:504–510
Druetta L, Croizet K, Bornet H, Rousset B (1998) Analyses of the molecular forms of serum thyroglobulin from patients with Graves' disease, subacute thyroiditis or differentiated thyroid cancer by velocity sedimentation on sucrose gradient and western blot. Eur J Endocrinol 139:498–507
Edmonds CJ, Willis CL (1988) Serum thyroglobulin in the investigation of patients presenting with metastases. Br J Radiol 61:317–319
Erali M, Bigelow RB, Meikle AW (1996) ELISA for thyroglobulin in serum: recovery studies to evaluate autoantibody interference and reliability of thyroglobulin values. Clin Chem 42:766–770
Eszlinger M, Neumann S, Otto L, Paschke R (2002) Thyroglobulin mRNA quantification in the peripheral blood is not a reliable marker for the follow-up of patients with differentiated thyroid cancer. Eur J Endocrinol 147:575–582
Eustatia-Rutten CF, Smit JW, Romijn JA, Kleij-Corssmit EP van der, Pereira AM, Stokkel MP, Kievit J (2004) Diagnostic value of serum thyroglobulin measurements in the follow-up of differentiated thyroid carcinoma, a structured meta-analysis. Clin Endocrinol (Oxf) 61:61–74
Fatemi S, LoPresti JS (2003) A consensus report of the role of serum thyroglobulin as a monitoring method for low-risk patients with papillary thyroid carcinoma. J Clin Endocrinol Metab 88:4507–4508
Feldt-Rasmussen U, Schlumberger M (1988) European interlaboratory comparison of serum thyroglobulin measurement. J Endocrinol Invest 11:175–181
Feldt-Rasmussen U, Hoier-Madsen M, Hansen HS, Blichert-Toft M (1986) Comparison between homogeneous phase radioassay and enzyme-linked immunosorbent assay for measurement of antithyroglobulin antibody content in serum. Relation to presence of thyroglobulin. Acta Pathol Microbiol Immunol Scand [C] 94:33–38
Feldt-Rasmussen U, Profilis C, Colinet E et al (1996a) Human thyroglobulin reference material (CRM 457). 1. Assessment of homogeneity, stability and immunoreactivity. Ann Biol Clin (Paris) 54:337–342
Feldt-Rasmussen U, Profilis C, Colinet E et al (1996b) A human thyroglobulin reference material (CRM 457). 2. Physicochemical characterization and certification. Ann Biol Clin (Paris) 54:343–348
Frasoldati A, Pesenti M, Gallo M, Caroggio A, Salvo D, Valcavi R (2003) Diagnosis of neck recurrences in patients with differentiated thyroid carcinoma. Cancer 97:90–96
Fugazzola L, Mihalich A, Persani L, Cerutti N, Reina M, Bonomi M, Ponti E, Mannavola D, Giammona E, Vannucchi G, di Blasio AM, Beck-Peccoz P (2002) Highly sensitive serum thyroglobulin and circulating thyroglobulin mRNA evaluations in the management of patients with differentiated thyroid cancer in apparent remission. J Clin Endocrinol Metab 87:3201–3208
Girelli ME, Busnardo B, Amerio R, Scotton G, Casara D, Betterle C, Piccolo M, Pelizzo MR (1985) Serum thyroglobulin levels in patients with well-differentiated thyroid cancer during suppression therapy: study on 429 patients. Eur J Nucl Med 10:252–254
Girelli ME, Busnardo B, Amerio R, Casara D, Betterle C, Piccolo M (1986) Critical evaluation of serum thyroglobulin (Tg) levels during thyroid hormone suppression therapy versus Tg levels after hormone withdrawal and total body scan: results in 291 patients with thyroid cancer. Eur J Nucl Med 11:333–335
Görges R, Brandt-Mainz K, Freudenberg L, Frilling A, Grimm W, Bockisch A (2003a) Kontinuierliche Sensitivitätssteigerung in der Schilddrüsenkarzinom-Nachsorge im Verlauf dreier Thyreoglobulin-IMA-Generationen. Nuklearmedizin 42:157–166
Görges R, Eising EG, Fotescu D, Renzing-Köhler K, Frilling A, Schmid KW, Bockisch A, Dirsch O (2003b) Diagnostic value of high-resolution B-mode and power-mode sonography in the follow-up of thyroid cancer. Eur J Ultrasound 16:191–206
Görges R, Tagay S, Matyssek K, Freudenberg L, Bockisch A, Langkafel M (2004) Einfluss der Schilddrüsenstoffwechsellage auf den psychosomatischen Status bei Schilddrüsenkarzinom-Patienten. In: Dietlein M, Schicha H (eds) Schilddrüse 2003: Zufallsbefund Schilddrüsenknoten — latente Schilddrüsenfunktionsstörungen. De Gruyter, Berlin, pp 374–80
Hjort T (1961) Determination of serum-thyroglobulin by a haemagglutination-inhibition test. Lancet 1:1262–1264
Hocevar M, Auersperg M, Stanovnik L (1997) The dynamics of serum thyroglobulin elimination from the body after thyroid surgery. Eur J Surg Oncol 23:208–210
Hüfner M, Stumpf HP, Grussendorf M, Hermann HJ, Kimmig B (1983) A comparison of the effectiveness of 131I whole body scans and plasma Tg determinations in the diagnosis of metastatic differentiated carcinoma of the thyroid: a retrospective study. Acta Endocrinol (Copenh) 104:327–332
Iervasi A, Iervasi G, Bottoni A, Boni G, Annicchiarico C, Cecco P di, Zucchelli GC (2004) Diagnostic performance of a new highly sensitive thyroglobulin immunoassay. J Endocrinol 182:287–294
Informationszentrum für Standards in der Onkologie (ISTO) (2001) Maligne Schilddrüsentumoren. Interdisziplinäre Leitlinie der Deutschen Krebsgesellschaft und der Deutschen Gesellschaft für Chirurgie, 3rd edn. http://www.uni-duesseldorf.de/WWW/AWMF/11/ (accessed 14 February 2005)
Kato R, Maruyama M, Sekino T, Kasuga Y (2000) A new assay for thyroglobulin concentration in serum using monoclonal antibodies against synthetic peptides. Clin Chim Acta 298:69–84
Langkafel M, Tagay S, Schöpper N, Bockisch A, Senf W, Görges R (2004) Befindlichkeitsstörungen und Lebensqualität bei Schilddrüsenfunktionsstörungen — insbesondere bei Hypothyreose und Schilddrüsenkarzinom. In: Dietlein M, Schicha H (eds) Schilddrüse 2003: Zufallsbefund Schilddrüsenknoten — latente Schilddrüsenfunktionsstörungen. De Gruyter, Berlin, pp 357–362
Ligabue A, Poggioli MC, Zacchini A (1993) Interference of specific autoantibodies in the assessment of serum thyroglobulin. J Nucl Biol Med 37:273–279
Lima N, Cavaliere H, Tomimori E, Knobel M, Medeiros-Neto G (2002) Prognostic value of serial serum thyroglobulin determinations after total thyroidectomy for differentiated thyroid cancer. J Endocrinol Invest 25:110–115
Lubin E, Mechlis-Frish S, Zatz S, Shimoni A, Segal K, Avraham A, Levy R, Feinmesser R (1994) Serum thyroglobulin and iodine-131 whole-body scan in the diagnosis and assessment of treatment for metastatic differentiated thyroid carcinoma. J Nucl Med 35:257–262
Mariotti S, Barbesino G, Caturegli P, Marino M, Manetti L, Pacini F, Centoni R, Pinchera A (1995) Assay of thyroglobulin in serum with thyroglobulin autoantibodies: an unobtainable goal? J Clin Endocrinol Metab 80:468–472
Mazzaferri EL (1999) An overview of the management of papillary and follicular thyroid carcinoma. Thyroid 9:421–427
Mazzaferri EL, Kloos RT (2002) Is diagnostic iodine-131 scanning with recombinant human TSH useful in the follow-up of differentiated thyroid cancer after thyroid ablation? J Clin Endocrinol Metab 87:1490–1498
Mazzaferri EL, Robbins RJ, Spencer CA, Braverman LE, Pacini F, Wartofsky L, Haugen BR, Sherman SI, Cooper DS, Braunstein GD, Lee S, Davies TF, Arafah BM, Ladenson PW, Pinchera A (2003a) A consensus report of the role of serum thyroglobulin as a monitoring method for low-risk patients with papillary thyroid carcinoma. J Clin Endocrinol Metab 88:1433–1441
Mazzaferri EL, Robbins RJ, Braverman LE, Pacini F, Haugen BR, Wartofsky L, Braunstein GD, Ladenson PW, Pinchera A (2003b) Authors response: a consensus report of the role of serum thyroglobulin as a monitoring method for low-risk patients with papillary thyroid carcinoma. J Clin Endocrinol Metab 88:4508–4510
Menzel C, Grünwald F, Biersack HJ (2003) Monitoring of low-risk patients with papillary thyroid carcinoma. J Clin Endocrinol Metab 88:4507
Mommert C, Görges R, Brandt-Mainz K, Hüsing J, Mergner J, Bockisch A (2000) Outcome of 1,017 patients with differentiated thyroid carcinoma and detection of recurrences. Eur J Nucl Med 27:1156 (abstract PS581)
Morgenthaler NG, Froehlich J, Rendl J, Willnich M, Alonso C, Bergmann A, Reiners C (2002) Technical evaluation of a new immunoradiometric and a new immunoluminometric assay for thyroglobulin. Clin Chem 48:1077–1083
Moriyama K, Akamizu T, Umemoto M, Miura M, Saijo M, Taniguchi K, Nakao K (1999) A case of Hashimotoʻs thyroiditis with markedly elevated serum thyroglobulin and evidence of its influence on the measurement of anti-thyroglobulin antibody by highly sensitive assays. Endocr J 46:687–693
Morris LF, Waxman AD, Braunstein GD (2002) Interlaboratory comparison of thyroglobulin measurements for patients with recurrent or metastatic differentiated thyroid cancer. Clin Chem 48:1371–1372
Müller-Gärtner HW, Schneider C, Tempel MT (1986) Serum-Thyreoglobulin in der Metastasendiagnostik des differenzierten Schilddrüsenkarzinoms. Nuklearmedizin 25:194–200
Müller-Gärtner HW, Schneider C (1988) Clinical evaluation of tumor characteristics predisposing serum thyroglobulin to be undetectable in patients with differentiated thyroid cancer. Cancer 61:976–981
Pacini F, Lippi F (1999) Clinical experience with recombinant human thyroid-stimulating hormone (rhTSH): serum thyroglobulin measurement. J Endocrinol Invest 22[Suppl 11]:25–29
Pacini F, Lari R, Mazzeo S, Grasso L, Taddei D, Pinchera A (1985) Diagnostic value of a single serum thyroglobulin determination on and off thyroid suppressive therapy in the follow-up of patients with differentiated thyroid cancer. Clin Endocrinol (Oxf) 23:405–411
Pellegriti G, Scollo C, Regalbuto C, Attard M, Marozzi P, Vermiglio F, Violi MA, Cianci M, Vigneri R, Pezzino V, Squatrito S (2003) The diagnostic use of the rhTSH/thyroglobulin test in differentiated thyroid cancer patients with persistent disease and low thyroglobulin levels. Clin Endocrinol (Oxf) 58:556–561
Petrich T, Börner AR, Weckesser E, Soudah B, Otto D, Widjaja A, Hofmann M, Kreipe HH, Knapp WH (2001) Nachsorge des differenzierten Schilddrüsenkarzinoms unter Verwendung von rhTSH — vorläufige Ergebnisse. Nuklearmedizin 40:7–14
Piechaczyk M, Baldet L, Pau B, Bastide JM (1989) Novel immunoradiometric assay of thyroglobulin in serum with use of monoclonal antibodies selected for lack of cross-reactivity with autoantibodies. Clin Chem 35:422–424
Preissner CM, O`Kane DJ, Singh RJ, Morris JC, Grebe SK (2003) Phantoms in the assay tube: heterophile antibody interferences in serum thyroglobulin assays. J Clin Endocrinol Metab 88:3069–3074
Quevedo I, Campino C, Rodriguez Portales JA, Arteaga E, Lopez JM, Campusano C, Gonzalez G, Fardella C, Slater J, Valdivia L, Poggi H, Foradori A, Velasco S (2002) Anti thyroglobulin antibodies in the follow-up of patients with differentiated thyroid cancer: residual or relapsing disease markers? Rev Med Chil 130:167–172
Reiners C, Reimann J, Schaffer R, Baum K, Becker W, Eilles C, Gerhards W, Schick F, Spiegel W, Wiedemann W et al (1984) Metastatic differentiated thyroid cancer. Diagnostic accuracy of thyroglobulin-RIA in comparison with 131I-whole body scintigraphy. Röfo 141:306–313
Ringel MD, Balducci-Silano PL, Anderson JS, Spencer CA, Silverman J, Sparling YH, Francis GL, Burman KD, Wartofsky L, Ladenson PW, Levine MA, Tuttle RM (1999) Quantitative reverse transcription-polymerase chain reaction of circulating thyroglobulin messenger ribonucleic acid for monitoring patients with thyroid carcinoma. J Clin Endocrinol Metab 84:4037–4042
Roitt IM, Torrigiani G (1967) Identification and estimation of undegraded thyroglobulin in human serum. Endocrinology 81:421–429
Ronga G, Fiorentino A, Paserio E, Signore A, Todino V, Tummarello MA, Filasi M, Baschieri I (1990) Can iodine-131 whole-body scan be replaced by thyroglobulin measurement in the post-surgical follow-up of differentiated thyroid carcinoma? J Nucl Med 31:1766–1771
Sapin R, Gasser F, Chambron J (1992) Recovery determination in 600 sera analyzed for thyroglobulin with a recently commercialized IRMA kit. Clin Chem 38:1920–1921
Schaadt B, Feldt-Rasmussen U, Rasmusson B, Torring H, Foder B, Jorgensen K, Hansen HS (1995) Assessment of the influence of thyroglobulin (Tg) autoantibodies and other interfering factors on the use of serum Tg as tumor marker in differentiated thyroid carcinoma. Thyroid 5:165–170
Schlumberger M, Pacini F (eds) (1999) Thyroid tumors. Serum thyroglobulin measurement, Chap 7.2.3. Éditions Nucléon, Paris, pp 136–140
Schlumberger M, Fragu P, Gardet P, Lumbroso J, Violot D, Parmentier C (1991) A new immunoradiometric assay (IRMA) system for thyroglobulin measurement in the follow-up of thyroid cancer patients. Eur J Nucl Med 18:153–157
Schlumberger M, Berg G, Cohen O, Duntas L, Jamar F, Jarzab B, Limbert E, Lind P, Pacini F, Reiners C, Sanchez Franco F, Toft A, Wiersinga WM (2004) Follow-up of low-risk patients with differentiated thyroid carcinoma: a European perspective. Eur J Endocrinol 150:105–112
Sheils OM, Sweeney EC (1999) TSH receptor status of thyroid neoplasms — TaqMan RTPCR analysis of archival material. J Pathol 188:87–92
Spencer CA, Takeuchi M, Kazarosyan M (1996); Current status and performance goals for serum thyroglobulin assays. Clin Chem 42:164–173
Spencer CA, Takeuchi M, Kazarosyan M, Wang CC, Guttler RB, Singer PA, Fatemi S, LoPresti JS, Nicoloff JT (1998) Serum thyroglobulin autoantibodies: prevalence, influence on serum thyroglobulin measurement, and prognostic significance in patients with differentiated thyroid carcinoma. J Clin Endocrinol Metab 83:1121–1127
Spencer CA, LoPresti JS, Fatemi S, Nicoloff JT (1999) Detection of residual and recurrent differentiated thyroid carcinoma by serum thyroglobulin measurement. Thyroid 9:435–441
Sulman C, Gosselin P, Carpentier P, Lemaire B (1984) Value of the estimation of thyroglobulin levels in the surveillance of treated differentiated thyroid carcinoma. J Clin Chem Clin Biochem 22:215–218
Szanto J, Vincze B, Sinkovics I, Karika Z, Daubner K, Peter I, Kazatsay I, Eckhardt S (1989) Postoperative thyroglobulin level determination to follow up patients with highly differentiated thyroid cancer. Oncology 46:99–104
Thyroid Carcinoma Task Force (2001) CE/AAES medical/surgical guidelines for clinical practice: management of thyroid carcinoma. American Association of Clinical Endocrinologists. American College of Endocrinology. Endocr Pract 7:202–220
Torlontano M, Crocetti U, D'Aloiso L, Bonfitto N, Di Giorgio A, Modoni S, Valle G, Frusciante V, Bisceglia M, Filetti S, Schlumberger M, Trischitta V (2003) Serum thyroglobulin and 131I whole body scan after recombinant human TSH stimulation in the follow-up of low-risk patients with differentiated thyroid cancer. Eur J Endocrinol 148:19–24
Torlontano M, Attard M, Crocetti U, Tumino S, Bruno R, Costante G, D'Azzo G, Meringolo D, Ferretti E, Sacco R, Arturi F, Filetti S (2004) Follow-up of low risk patients with papillary thyroid cancer: role of neck ultrasonography in detecting lymph node metastases. J Clin Endocrinol Metab 89:3402–3407
Van Herle AJ, Uller RP, Matthews NI, Brown J (1973) Radioimmunoassay for measurement of thyroglobulin in human serum. J Clin Invest 52:1320–1327
Van Wyngaarden K, McDougall IR (1997) Is serum thyroglobulin a useful marker for thyroid cancer in patients who have not had ablation of residual thyroid tissue? Thyroid 7:343–346
Verburg FA, Lips CJ, Lentjes EG, Klerk JM de (2004) Detection of circulating Tg-mRNA in the follow-up of papillary and follicular thyroid cancer: how useful is it? Br J Cancer 91:200–204
Wang PW, Wang ST, Liu RT, Chien WY, Tung SC, Lu YC, Chen HY, Lee CH (1999) Levothyroxine suppression of thyroglobulin in patients with differentiated thyroid carcinoma. J Clin Endocrinol Metab 84:4549–4553
Wartofsky L (2002) Using baseline and recombinant human TSH-stimulated Tg measurements to manage thyroid cancer without diagnostic (131)I scanning. J Clin Endocrinol Metab 87:1486–1489
Weightman DR, Mallick UK, Fenwick JD, Perros P (2003) Discordant serum thyroglobulin results generated by two classes of assay in patients with thyroid carcinoma: correlation with clinical outcome after 3 years of follow-up. Cancer 98:41–47
Wunderlich G, Zöphel K, Crook L, Smith S, Smith BR, Franke WG (2001) A high-sensitivity enzyme-linked immunosorbent assay for serum thyroglobulin. Thyroid 11:819–824
Zöphel K, Wunderlich G, Liepach U, Koch R, Bredow J, Franke WG (2001) Recovery test or immunoradiometric measurement of anti-thyroglobulin autoantibodies for interpretation of thyroglobulin determination in the follow-up of different thyroid carcinoma. Nuklearmedizin 40:155–163
Zöphel K, Wunderlich G, Smith BR (2003) Serum thyroglobulin measurements with a high sensitivity enzyme-linked immunosorbent assay: is there a clinical benefit in patients with differentiated thyroid carcinoma? Thyroid 13:861–865
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2005 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Görges, R., Bockisch, A. (2005). Thyroglobulin as Specific Tumor Marker in Differentiated Thyroid Cancer. In: Biersack, HJ., Grünwald, F. (eds) Thyroid Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27845-1_13
Download citation
DOI: https://doi.org/10.1007/3-540-27845-1_13
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-22309-2
Online ISBN: 978-3-540-27845-0
eBook Packages: MedicineMedicine (R0)