Abstract
Structural studies of foot-and-mouth disease virus (FMDV) have largely focused on the mature viral particle, providing atomic resolution images of the spherical protein capsid for a number of sero- and sub-types, structures of the highly immunogenic surface loop, Fab and GAG receptor complexes. Additionally, structures are available for a few non-structural proteins. The chapter reviews our current structural knowledge and its impact on our understanding of the virus life cycle proceeding from the mature virus through immune evasion/inactivation, cell-receptor binding and replication and alludes to future structural targets.
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Fry, E.E., Stuart, D.I., Rowlands, D.J. (2005). The Structure of Foot-and-Mouth Disease Virus. In: Mahy, B.W. (eds) Foot-and-Mouth Disease Virus. Current Topics in Microbiology and Immunology, vol 288. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27109-0_4
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