Summary
Cerebrolysin is used as a neurotrophic agent for the treatment of ischemic stroke and Alzheimer’s Disease. Exploratory studies in patients with post-acute traumatic brain injury have shown that this treatment might help improve recovery. Aim of this study was to investigate whether addition of Cerebrolysin to the initial treatment regimen of moderate and severe head injury patients would improve their outcome.
At 6 months, 67% of the patients (Cerebrolysin group) attained good outcome (GOS 3–5). The study group was compared with the historical cohort of patients from the hospital trauma data bank, with age, sex and admitting GCS matching. More patients tended to a good outcome in the Cerebrolysin group (P = 0.065). No significant side-effect requiring cessation of Cerebrolysin was noted.
It can be concluded that the use of Cerebrolysin as part of the initial management of moderate and severe head injury is safe and well tolerated. The results suggest that Cerebrolysin is beneficial in regard to the outcome in these patients, especially in elderly patients.
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References
Anton A, Sampedro C, Perez P et al (2003) Positive effects of Cerebrolysin on electroencephalogram slowing, cognition and clinical outcome in patients with postacute traumatic brain injury: an exploratory study. International Clinical Psychopharmacology 18: 271–278
Bae CY, Cho CY, Cho K et al (2000) A double-blind, placebo-controlled, multicenter study of cerebrolysin for Alzheimer’s Disease. Journal of American Geriatric Society 48: 1566–1571
Jennett B, Bond M (1975) Assessment of outcome after severe brain damage, a practical scale. Lancet 1: 480–484
Jennett B, Teasdale G, Braakman R (1979) Prognosis of patients with severe brain injury. Neurosurgery 4: 283–289
Katz DI, Alexander MP (1994) Traumatic brain injury. Predicting course of recovery and outcome for patients admitted to rehabilitation. Arch Neurol 51(7): 661–670
Prigatano GP (1988) Rehabilitation intervention after traumatic brain injury. BNI Quarterly 4: 30–37
Rice-Oxley M, Turner-Stokes L (1999) Effectiveness of brain injury rehabilitation. Clin Rehab 13(S1): 7–24
Ruether E, Ritter R, Apecechea M, Freytag S, Gmeinbauer R, Windisch M (2000) Sustained improvements in patients with dementia of Alzheimer’s type (DAT) 6 months after termination of cerebrolysin therapy. J Neural Transm 107(7): 815–829
Valouskova V, Francis-Turner L (1998) Can cerebrolysin influence chronic deterioration of spatial learning and memory? J Neural Transm [Suppl] 53: 343–349
Wilson JTL, Pettigrew LEL, Teasdale GM (2000) Emotional and cognitive consequences of head injury in relation to the Glasgow outcome scale. J Neurol Neurosurg Psychiatry 69: 204–209
Xiao S, Yan H, Yao P: The Cerebrolysin Study Group (2000) Efficacy of FPF 1070 (Cerebrolysin) in patients with Alzheimer’s Disease. Clin Drug Invest 19(1): 43–53
Zhu XL, Poon WS, Chan CH, Chan SH (2001) Does intensive rehabilitation improve the functional outcome of patients with traumatic brain injury? Interim result of a randomized controlled trial. Brit J Neurosurg 15(6): 464–473
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© 2005 Springer-Verlag
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Wong, G.K.C., Zhu, X.L., Poon, W.S. (2005). Beneficial effect of cerebrolysin on moderate and severe head injury patients: result of a cohort study. In: Poon, W.S., et al. Intracranial Pressure and Brain Monitoring XII. Acta Neurochirurgica Supplementum, vol 95. Springer, Vienna. https://doi.org/10.1007/3-211-32318-X_13
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DOI: https://doi.org/10.1007/3-211-32318-X_13
Publisher Name: Springer, Vienna
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