Abstract
Details of our recent attempts to clarify the self-organization mechanism of hydroxyapatite (HAp) mineralization in natural bodies are presented in this work. In biomineralization processes, inorganic crystals precipitate onto organic matrix surfaces. Organic molecules assembled to monolayer films were employed to reproduce the organic matrices in natural bodies, and the HAp mineralization process onto the organic monolayers were subjected to spectroscopic and structural analytical approaches. Knowledge of interfacial atomic structures is also essential for interpretation of the inorganic-organic interface. We determined the most stable atomic arrangement of the HAp 100 facet using high-resolution transmission electron microscopy. A mechanism of HAp mineralization proposed in view of the experimental results is the highlight of this work.
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Abbreviations
- DF:
-
defocus
- FT-IR:
-
Fourier transform IR
- HAp:
-
hydroxyapatite
- HRTEM:
-
high-resolution transmission electron microscopy
- LB:
-
Langmuir–Blodgett
- OCP:
-
octacalcium phosphate
- SAED:
-
selected area electron diffraction
- SAM:
-
self-assembled monolayer
- SBF:
-
simulated body fluid
- SEM:
-
scanning electron microscopy
- TEM:
-
transmission electron microscopy
- TF-XRD:
-
thin-film X-ray diffraction
- XRD:
-
X-ray diffraction
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Acknowledgments
I am pleased to acknowledge the collaborators who have supported and nurtured this work, in particular, Prof. Junzo Tanaka (Tokyo Institute of Technology), Prof. Toshihiro Kogure (University of Tokyo) and Ms. Yuri Kumagai (Japan Science and Technology Agency, CREST). More recently, the support of Dr. Koji Watari (AIST) has been significant.
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Sato, K. (2006). Inorganic-Organic Interfacial Interactions in Hydroxyapatite Mineralization Processes. In: Naka, K. (eds) Biomineralization I. Topics in Current Chemistry, vol 270. Springer, Berlin, Heidelberg . https://doi.org/10.1007/128_075
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DOI: https://doi.org/10.1007/128_075
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