Abstract
The induction of apoptosis plays a key role in non-surgical cancer treatment — whether this occurs by irradiation, chemotherapy, or hormones. Recent advancements in imaging science and metabolic studies by nuclear magnetic resonance have painted an intriguing picture of the metabolic and biophysical processes involved with the progression of apoptosis in situ. It is now possible for us to detect and visualize previously inaccessible and even unrecognized biological phenomena in living cells and tissues undergoing therapeutically induced apoptosis. These new imaging techniques will have an increasing impact in the preclinical design of new anticancer agents and novel treatment protocols to enhance apoptotic cascades and to combat drug resistance. With the advent of molecular medicine and patient-tailored therapeutic options and drug molecules, rapid and accurate visualization of apoptotic response in the clinical settings can be of significant diagnostic and prognostic worth.
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Hakumäki, J. (2005). Imaging of Apoptotic Cells in vivo. In: Application of Apoptosis to Cancer Treatment. Springer, Dordrecht. https://doi.org/10.1007/1-4020-3302-8_14
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DOI: https://doi.org/10.1007/1-4020-3302-8_14
Publisher Name: Springer, Dordrecht
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