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Theoretical and Computational Approaches to the Study of the Origin of Life

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Origins

Part of the book series: Cellular Origin, Life in Extreme Habitats and Astrobiology ((COLE,volume 6))

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5. References

  • Allamandola, L.J., Hudgins, D.M., Bauschlicher Jr., C.W. and Langhoff, S.R. (1999) Carbon chain abundance in the diffuse interstellar medium. Astron. Astrophys., 352, 659–664.

    CAS  Google Scholar 

  • Altreuter, D.H. and Clark, D.S. (1999) Combinatorial biocatalysis: taking the lead from nature. Curr. Opin. Biotechnol., 10, 130–136.

    Article  CAS  Google Scholar 

  • Alves, D. and Fontanari, J.F. (1998) Error threshold in finite populations. Phys. Rev. E, 57, 7008–7013.

    Article  CAS  Google Scholar 

  • Anders, E. (1989) Prebiotic organic matter from comets and asteroids. Nature, 342, 255–257.

    Article  CAS  Google Scholar 

  • Arnett, D. (1996) Supernovae and nucleosynthesis. Princeton Univ. Press, Princeton, NJ.

    Google Scholar 

  • Arnett, D. and Bazan, G. (1997) Nucleosynthesis in stars: recent developments. Science, 276, 1359–1362.

    Article  CAS  Google Scholar 

  • Bachmann, P., Luisi, P. and Lang, J. (1992) Autocatalytic self-replicating micelles as models for prebiotic structures. Nature, 357, 57–59.

    Article  CAS  Google Scholar 

  • Bagley, R.J. and Farmer, J.D. (1991) Spontaneous emergence of a metabolism. In: C.G. Langton, C. Taylor, J.D. Farmer and S. Rasmussen (eds.), Artificial Life II. Addison-Wesley, Vol. X, pp. 93–140.

    Google Scholar 

  • Bagley, R.J., Farmer, J.D. and Fontana, W. (1991) Evolution of a metabolism. In: C.G. Langton, C. Taylor, J.D. Farmer and S. Rasmussen (eds.), Artificial Life II. Addison-Wesley, Vol. X, pp. 141–158.

    Google Scholar 

  • Bak, P. and Sneppen, K. (1993) Punctuated equilibrium and criticality in a simple model of evolution, Phys. Rev. Lett., 71, 4083–4086.

    Article  CAS  Google Scholar 

  • Bak, P., Tang, C. and Wiesenfeld, K. (1987) Self-Organized Criticality: An explanation of 1/f Noise, Phys. Rev. Lett, 59, 381–384.

    Article  Google Scholar 

  • Bartel, D.P. and Unrau, P.J. (1999) Constructing an RNA world. TIBS (Millennium Issue), 24, M9–M13.

    CAS  Google Scholar 

  • Bartholomay, A.F. (1962) A stochastic approach to statistical kinetics with application to enzyme kinetics. Biochemistry, 1,223–230.

    Article  CAS  Google Scholar 

  • Ben-Eli, D. (2000) M.Sc. Thesis. The Weizmann Institute of Science, Rehovot, Israel.

    Google Scholar 

  • Bernstein, M.P., Sandford, S.A., Allamandola, L.J., Gilette, J.S., Clemett, S.J. and Zare, R.N. (1999) UV irradiation of polycyclic aromatic hydrocarbons in ices: production of alcohols, quinones, and ethers. Science, 283, 1135–1138.

    Article  CAS  Google Scholar 

  • Bolhuis, H., van, V.H., Poolman, B., Driessen, A.J. and Konings, W.N. (1997) Mechanisms of multidrug transporters. Fems Microbiol. Rev., 21, 55–84.

    CAS  Google Scholar 

  • Bolhuis, P.G. and Frenkel, D. (1997) Microscopic and mesoscopic simulation of entropic micelles. Physica A, 244, 45–58.

    Article  CAS  Google Scholar 

  • Bolli, M., Micura, R and Eschenmoser, A. (1997) Pyranosyl-RNA: chiroselective self-assembly of base sequences by ligative oligomerization of tetranucleotide-2′,3′-cyclophosphates (with a commentary concerning the origin of biomolecular homochirality). Chemistry & Biology, 4, 309–320.

    Article  CAS  Google Scholar 

  • Bonaccio, S., Walde, P. and Luisi, P.L. (1994) Liposomes containing purine and pyrimidine bases: stable unilamellar liposomes from phosphatidyl nucleosides. J. Phys. Chem., 98, 6661–6663.

    Article  CAS  Google Scholar 

  • Buck, L. and Axel, R. (1991) A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell, 65, 175–187.

    Article  CAS  Google Scholar 

  • Buhse, T., Pimienta, V., Lavabre, D. and Micheau, J.-C. (1997) Experimental evidence of kinetic bistability in a biphasic surfactant system. J. Phys. Chem. A, 101, 5215–5217.

    Article  CAS  Google Scholar 

  • Burnet, F.M. (1963) Cold Spring Harbor Symp. Quant. Biol., 32, 1.

    Google Scholar 

  • Cairns-Smith, G. (1982) Genetic takeover and the mineral origins of life. Cambridge University Press, Cambridge, UK.

    Google Scholar 

  • Cech, T.R. (1986) A model for the RNA-catalyzed replication of RNA. Proc. Natl. Acad. Sci. USA, 83, 4360–4363.

    CAS  Google Scholar 

  • Chou, H.-H., Reggia, J.A., Navarro-Gonzalez, R. and Wu, J. (1994) An extended cellular space method for simulating autocatalytic oligonucleotides. Computers Chem., 18, 33–43.

    Article  CAS  Google Scholar 

  • Chyba, C.F. and Sagan, C. (1992) Endogenous production, exogenous delivery and impact-shock synthesis of organic molecules: An inventory for the origin of life. Nature, 355, 125–132.

    Article  CAS  Google Scholar 

  • Collins, J. (1997) Phage display. In: A.D. Ellington, W.H. Moos, M.R. Pavia and B.K. Kay (eds.), Annual Reports in Combinatorial Chemistry and Molecular Diversity. ESCOM, The Netherlands, Vol. 1, pp. 210–262.

    Google Scholar 

  • Cousins, G.R., Poulsen, S.A. and Sanders, J.K. (2000) Molecular evolution: dynamic combinatorial libraries, autocatalytic networks and the quest for molecular function. Curr. Opin. Chem. Biol., 4, 270–279.

    Article  CAS  Google Scholar 

  • Crick, F. (1981) Life itself. Simon and Schuster, New York.

    Google Scholar 

  • Cupp, M.J. and Tracy, T.S. (1998) Cytochrome P450: new nomenclature and clinical implications. Am. Fam. Physician, 57, 107–16.

    CAS  Google Scholar 

  • Dawkins, R. (1996) The River out of Eden. Phoenix Press.

    Google Scholar 

  • de Duve, C. (1995) Vital Dust. Harper Collins Publishers.

    Google Scholar 

  • de Graaf, R.M., Visscher, J. and Schwartz, A.W. (1995) A plausibly prebiotic synthesis of phosphonic acids. Nature, 378, 474–477.

    Article  Google Scholar 

  • Deamer, D.W. (1985) Boundary structures are formed by organic components of the Murchison carbonaceous chondrite. Nature, 317, 792–794.

    Article  CAS  Google Scholar 

  • Deamer, D.W. (1986) Role of amphiphilic compounds in the evolution of membrane structure on the early earth. Origins of Life, 17, 3–25.

    Article  CAS  Google Scholar 

  • Doty, S.D. and Leung, C.M. (1998) Detailed chemical modeling of the circumstellar envelopes of carbon stars: application to IRC +10216. The Astrophys. J., 502, 898–908.

    Article  CAS  Google Scholar 

  • Dyson, F. (1999) Origins ofLife. Cambridge University Press, Cambridge.

    Google Scholar 

  • Dyson, F.J. (1982) Amodel for the origin of life. J. Mol. Evol., 18, 344–350.

    Article  CAS  Google Scholar 

  • Dyson, F.J. (1985) Origins of life. Cambridge University Press, Cambridge.

    Google Scholar 

  • Ehrenfreund, P. and Charnley, B. (2000) Organic molecules in the interstellar medium, comets and meteorites: a voyage from dark clouds to the early Earth. Annu. Rev. Astron. Astrophys., 38, 427–483.

    Article  CAS  Google Scholar 

  • Eigen, M. (1971) Selforganization of matter and the evolution of biological macromolecules. Naturwissenschaften, 58,465–523.

    Article  CAS  Google Scholar 

  • Eigen, M. (2000) Natural selection: a phase transition? Biophys. Chem., 25, 101–123.

    Article  Google Scholar 

  • Eigen, M. and Schuster, P. (1979) The Hypercycle. Springer Verlag, Berlin.

    Google Scholar 

  • Ellington, A.D., Robertson, M.P. and Bull, J. (1997) Ribozymes in Wonderland. Science, 276, 546–547.

    Article  CAS  Google Scholar 

  • Farmer, J.D., Kauffman, S.A. and Packard, N.H. (1986) Autocatalytic replication of polymers. Physica, 22D, 50–67.

    CAS  Google Scholar 

  • Fendler, H.J. and Fendler, E.J. (1975) Catalysis in Micellar and Macromolecular Systems. Academic Press, New York.

    Google Scholar 

  • Fendler, J.H. (1982) Membrane Mimetic chemistry. Wiley, New York.

    Google Scholar 

  • Fendler, J.H. (1987) Atomic and Molecular Clusters in Membrane Mimetic Chemistry. Chem. Rev., 87, 877–899.

    Article  CAS  Google Scholar 

  • Fontana, W. and Buss, L.W. (1994) What would be conserved if “the tape were played twice”? Proc. Natl. Acad. Sci. USA., 91, 757–761.

    CAS  Google Scholar 

  • Fox, S.W. (1976) The evolutionary significance of phase-separated microsystems. Origin Life Evol. Biosphere, 7, 49–68.

    Article  CAS  Google Scholar 

  • Fox, S.W. (1991) Synthesis of life in the lab? Defining a protoliving system. Q. Rev. Biol., 66, 181–5.

    Article  CAS  Google Scholar 

  • Fraser, C.L. and Folsome, C.E. (1975) Exponential kinetics of formation or organic microstructures. Orig. Life, 6, 429–33.

    Article  CAS  Google Scholar 

  • Fry, I. (2000) The Emergence of Life on Earth: A Historical and Scientific Overview. Rutgers Univ. Press.

    Google Scholar 

  • Gesteland, R.F., Cech, T.R. and Atkins, J.F. (1999) The RNA world, Second Edition. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.

    Google Scholar 

  • Gilbert, W. (1986) The RNA world. Nature, 319, 618–618.

    Article  Google Scholar 

  • Gillespie, D. (1977) Exact stochastic simulation of coupled chemical reactions. J. Phys. Chem., 81, 2340–2360.

    Article  CAS  Google Scholar 

  • Glusman G., Yanai I., Rubin I., Lancet D. (2001) The complete human olfactory subgenome. Genome Res. 2001, 11, 685–702.

    Article  CAS  Google Scholar 

  • Goetz, R. and Lipowsky, R. (1998) Computer simulations of bilayer membranes: Self-assembly and interfacial tension. J. Chem. Phys., 108, 7397–7409.

    Article  CAS  Google Scholar 

  • Gold, L., Brown, D., He, Y.-Y., Shtatland, T., Singer, B.S. and Wu, Y. (1997) From oligonucleotide shapes to genomic SELEX: Novel biological regulatory loops. Proc. Natl. Acad. Sci. USA, 94, 59–64.

    Article  CAS  Google Scholar 

  • Hoogenboom, H.R. (1997) Designing and optimizing library selection strategies for generating high-affinity antibodies. Trends Biotechnol., 15, 62–70.

    Article  CAS  Google Scholar 

  • Horowitz, N.H. (1945) On the evolution of biochemical syntheses. Proc. Natl. Acad. Sci. USA, 31, 153–157.

    CAS  Google Scholar 

  • Huber, C. and Wachtershauser, G. (1997) Activated acetic acid by carbon fixation on (Fe, Ni)S under primordial conditions. Science, 276, 245–247.

    Article  CAS  Google Scholar 

  • Inman, J.K. (1978) The antibody combining region: Speculations on the hypothesis of general multispecificity. In: G.I. Bell, A.S. Perelson and G.H. Jr. Pimbly (eds.), Theoretical Immunology. Marcell Dekker, New York, pp. 243–278.

    Google Scholar 

  • Irvine, W.M. (1998) Extraterrestrial organic matter: a review. Origins Life Evol. Biosphere, 28, 365–383.

    Article  CAS  Google Scholar 

  • Jain, S. and Krishna, S. (1998) Autocatalytic sets and the growth of complexity in an evolutionary model. Phys. Rev. Lett., 81, 5684–5687.

    Article  CAS  Google Scholar 

  • Janda, K.D., Lo, L.C., Lo, C., Sim, M.M., Wang, R., Wong, C.H. and Lerner, R.A. (1997) Chemical selection for catalysis in combinatorial antibody libraries. Science, 275, 945–8.

    Article  CAS  Google Scholar 

  • Joyce, G.F. (1991) The rise and fall of the RNA world. The New Biologist, 3, 399–407.

    CAS  Google Scholar 

  • Kafri, R. (2002) M.Sc. Thesis, Weizmann Institute of Science, Israel.

    Google Scholar 

  • Kauffman, S. (1996) Evenpeptides do it. Nature, 382, 496–497.

    Article  CAS  Google Scholar 

  • Kauffman, S.A. (1986) Autocatalytic sets of proteins. J. Theor. Biol., 119, 1–24.

    CAS  Google Scholar 

  • Kauffman, S.A. (1993) The origins of order, Oxford University Press, Oxford.

    Google Scholar 

  • Kauvar, L.M., Higgins, D.L., Villar, H.O., Sportsman, J.R., Engqvist-Goldstein, A., Bukar, R, Bauer, K.E., Dilley, H. and Rocke, D.M. (1995) Predicting ligand binding to proteins by affinity fingerprinting. Chem. Biol., 2, 107–18.

    Article  CAS  Google Scholar 

  • Kerr, R.A. (1996) Ancient life on Mars? Science, 273, 864–866.

    CAS  Google Scholar 

  • Koch, A.L. (1985) Primeval cells: possible energy-generating and cell-division mechanisms. J. Mol. Evol., 21, 270–277.

    Article  CAS  Google Scholar 

  • Kondepudi, D.K. and Nelson, G.W. (1985) Weak neutral currents and the origin of bio-molecular chirality. Nature, 314,438–441.

    Article  CAS  Google Scholar 

  • Kuppers, B.-O. (1983) Molecular theory of evolution. Springer-Verlag, Berlin-Heidelberg.

    Google Scholar 

  • Lahav, N. (1999) Biogenesis: Theories of Life’s origin. Oxford University Press, NY.

    Google Scholar 

  • Lancet, D. (1986) Vertebrate olfactory reception. Annu. Rev. Neurosci., 9, 329–55.

    Article  CAS  Google Scholar 

  • Lancet, D. and Ben-Arie, N. (1993) Olfactory receptors. Current Biology, 3, 668–674.

    Article  CAS  Google Scholar 

  • Lancet, D., Horovitz, A. and Katchalski-Katzir, E. (1994a) Molecular recognition in biology: Models for analysis of protein/ligand interactions. In: J.-P. Behr (ed.), Perspectives in supramolecular chemistry. J. Wiley New-York, pp. 25–71.

    Google Scholar 

  • Lancet, D., Kedem, O. and Pilpel, Y. (1994b) Emergence of order in small autocatalytic sets maintained far from equilibrium: application of receptor affinity distribution (RAD) model. Ber. Bunsenges. Phys. Chem., 98, 1166–1169.

    CAS  Google Scholar 

  • Lancet, D., Sadovsky, E. and Seidemann, E. (1993) Probability model for molecular recognition in biological receptor repertoires: Significance to the olfactory system. Proc. Natl. Acad. Sci. USA., 90, 3715–3719.

    CAS  Google Scholar 

  • Lee, D.H., Granja, J.R., Martinez, J.A., Severin, K. and Ghadiri, M.R. (1996) A self-replicating peptide. Nature, 382, 525–528.

    Article  CAS  Google Scholar 

  • Lee, D.H., Severin, K., Yokobayashi, Y. and Ghadiri, M.R. (1997) Emergence of symbiosis in peptide self-replication through a hypercyclic network. Nature, 390, 591–594.

    Article  CAS  Google Scholar 

  • Levitan, B. (1997) Models and search strategies for applied molecular evolution. In: A.D. Ellington, W.H. Moos, M.R. Pavia and B.K. Kay (eds.), Annual Reports in Combinatorial Chemistry and Molecular Diversity. ESCOM, The Netherlands, Vol. 1, pp. 95–152.

    Google Scholar 

  • Levitan, B. (1998) Stochastic Modeling and Optimization ofPhage Display. J. Mol. Biol., 277, 893–916.

    Article  CAS  Google Scholar 

  • Li, T. and Nicolaou, K.C. (1994) Chemical self-replication of palindromic duplex DNA. Nature, 369, 218–221.

    Article  CAS  Google Scholar 

  • Li, W.-H. and Graur, D. (1991) Fundamentals of Molecular Evolution, Sinauer Associates, Sunderland, MA.

    Google Scholar 

  • Lifson, S. (1996) On the crucial stages in the origin of animate matter. J. Mol. Evol., 44, 1–8.

    Article  Google Scholar 

  • Lissauer, J.J., Marcy, G.W. and Ida, S. (2000) Extrasolar planets. Proc. Natl. Acad. Sci. USA, 97, 12405–12406.

    Article  CAS  Google Scholar 

  • Lohse, PA. and Szostak, J.W. (1996) Ribozyme-catalysed amino-acid transfer reactions. Nature, 381, 442–444.

    Article  CAS  Google Scholar 

  • Lorsch, J.R. and Szostak, J.W. (1994) In vitro selection of RNA aptamers specific for cyanocobalamin. Biochemistry, 33, 973–982.

    Article  CAS  Google Scholar 

  • Luisi, P.L. (1997) Self-reproduction of chemical structures and the question of the transition to life. In: C.B. Cosmovici, S. Bowyer and D. Werthimer (eds.), Astronomical and Biochemical Origins and the Search for Life in the Universe, Editrice Compositori, Bologna, pp. 461–468.

    Google Scholar 

  • Luisi, P.L., Walde, P. and Oberholzer, T. (1999) Lipid vesicles as possible intermediates in the origin of life. Curr. Opinions in Colloid & Interface Sci., 4, 33–39.

    Article  CAS  Google Scholar 

  • Macià, E., Hernandez, M.V. and Oró, J. (1997) Primary sources of phosphorus and phosphates in chemical evolution. Origins Life Evol. Biosphere, 27, 459–480.

    Article  Google Scholar 

  • Macken, CA. and Perelson, A.S. (1991) Affinity maturation on rugged landscapes. In: A.S. Perelson and S.A. Kauffman (eds.), Molecular Evolution on Rugged Landscapes: Santa Fe Institute Studies in the Sciences of Complexity. Addison-Wesley, Reading, MA, Vol. 9, pp. 93–118.

    Google Scholar 

  • Maden, B.E. (1995) No soup for starters? Autotrophy and the origins of metabolism. TIBS, 20, 337–341.

    CAS  Google Scholar 

  • Maher, K.A. and Stevenson, J.D. (1988) Impact frustration of the origin of life. Nature, 331, 612–614.

    Article  CAS  Google Scholar 

  • Mason, S.F. (1984) Origins of biomolecularhandedness. Nature, 311, 19–23.

    Google Scholar 

  • McCollom, T.W., Ritter, G. and Simoneit, B.R.T. (1999) Lipid synthesis under hydrothermal conditions by Fisher-Tropsch-type reactions. Origins Life Evol. Biosphere, 29, 153–166.

    Article  CAS  Google Scholar 

  • McDonald, G.D., Whited, L.J., DeRuiter, C, Khare, B.N., Patnaik, A. and Sagan, C. (1996) Production and chemical analysis of cometary ice tholins. Icarus, 122, 107–117.

    Article  CAS  Google Scholar 

  • McKay, C.P. (1997) Life in comets. In: P.J. Thomas, C.F. Chyba and C.P. McKay (eds.), Comets and the origin and evolution of life. Springer Verlag, New York, pp. 273–282.

    Google Scholar 

  • McKay, D.S., Gibson Jr., E.K., Thomas-Keprta, K.L., Vali, H., Romanek, C.S., Clemett, S.J., Chillier, X.D.F., Maechling, C.R. and Zare, R.N. (1996) Search for past life on Mars: possible relic biogenic activity in Martian meteorite ALH84001. Science, 273, 924–930.

    CAS  Google Scholar 

  • McMullin, B. (1995) Replicators Don’t! In: F. Moran, A. Moreno, J.J. Merelo and P. Cachon (eds.), Advances in Artificial Life. Springer, Granada, Spain, pp. 158–169.

    Google Scholar 

  • Miller, S.L. (1953) A production of amino acids under possible primitive earth conditions. Science, 117, 528–529.

    CAS  Google Scholar 

  • Miller, S.L. and Urey, H.C. (1959) Organic compound synthesis on the primitive Earth. Science, 130, 245–251.

    CAS  Google Scholar 

  • Miyakawa S., Yamanashi H., Kobayashi K., Cleaves H.J. and Miller SL. (2002) Prebiotic synthesis from CO atmospheres: implications for the origins of life. Proc. Natl. Acad. Sci. USA, 99, 14628–14631.

    Article  CAS  Google Scholar 

  • Mojzsis, S.J., Arrhenius, G., McKeegan, K.D., Harrison, T.M., Nutman, A.P. and Friend, C.R. (1996) Evidence for life on Earth before 3,800 million years ago. Nature, 384, 55–59.

    Article  CAS  Google Scholar 

  • Mojzsis, S.J., Krishnamurthy, R. and Arrhenius, G. (1998) Before RNA and After: Geophysical and Geochemical Constraints on Molecular Evolution. In: R.F. Gesteland, T.R. Cech and J.F. Atkins (eds.), The RNA world, Second Edition. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, pp. 1–47.

    Google Scholar 

  • Moore, J.C., Jin, H.-M., Kuchner, O. and Arnold, F.H. (1997) Strategies for the in vitro evolution of protein function: enzyme evolution by random recombination of improved sequences. J. Mol. Biol., 272, 336–347.

    Article  CAS  Google Scholar 

  • Morowitz, H.J. (1967) Biological self-replicating systems. In: F.M. Snell (ed.), Progress in Theoretical Biology. Academic Press, Vol. 1, pp. 35–58.

    Google Scholar 

  • Morowitz, H.J. (1979) Energy flow in biology. Academic Press, New York.

    Google Scholar 

  • Morowitz, H.J. (1992) Beginnings of cellular life. Yale University Press, London.

    Google Scholar 

  • Morowitz, H.J., Heinz, B. and Deamer, D.W. (1988) The chemical logic of a minimum protocell. Origins Life Evol. Biosphere, 18, 281–287.

    Article  CAS  Google Scholar 

  • Muller, H.J. (1966) The gene material as the initiator and the organizing basis of life. Am. Nat., 100, 493–517.

    Article  Google Scholar 

  • Nekovee, M., Coveney, P.V., Chen, H. and Boghosian, B.M. (2000) Lattice-Boltzmann model for interacting amphiphilic fluids. Phys. Rev. E, 62, 8282–8294.

    Article  CAS  Google Scholar 

  • New, M.H. and Pohorille, A. (2000) An inherited efficiencies model of non-genomic evolution. Simulation Practice and Theory, 8, 99–108.

    Article  Google Scholar 

  • Newman, M.E.J. and Sneppen, K. (1996) Avalanches, scaling and coherent noise. Phys. Rev. E, 54, 6226–6231.

    Article  CAS  Google Scholar 

  • Nicolis, G. and Prigogine, I. (1977) Self-organization in nonequilibrium systems. Wiley & Sons, Toronto.

    Google Scholar 

  • Niesert, U., Harnasch, D. and Bresch, C. (1981) Origin of life between scylla and charybdis. J. Mol. Evol., 17, 348–353.

    Article  CAS  Google Scholar 

  • Norman, M. (1998) Cosmos in a Computer. Science, 280, 1522–1523.

    Article  Google Scholar 

  • Oberholzer, T., Wick, R., Luisi, P.L. and Biebricher, C.K. (1995) Enzymatic RNA replication in self-reproducing vesicles: an approach to a minimal cell. Biochem. Biophys. Res. Commun., 207, 250–257.

    Article  CAS  Google Scholar 

  • Oberhummer, H., Csoto, A. and Schlattl, H. (2000) Stellar production rates of carbon and its abundance in the universe. Science, 289, 88–90.

    Article  CAS  Google Scholar 

  • Oparin, A.I., and Gladilin, K. L., (1980) Evolution of self-assembly of probionts. BioSystems, 12, 133–145.

    Article  CAS  Google Scholar 

  • Oparin, A.I. (1957) The origin of life on the earth. Oliver and Boyd, London.

    Google Scholar 

  • Orgel, L. (1998) The origin of life — a review of facts and speculations. TIBS, 23, 491–495.

    CAS  Google Scholar 

  • Orgel, L.E. (1968) Evolution of the genetic apparatus. J. Mol. Biol., 38, 381–393.

    Article  CAS  Google Scholar 

  • Orgel, L.E. (1992) Molecular replication. Nature, 358, 203–209.

    Article  CAS  Google Scholar 

  • Orò, J. (2000) Organic matter and the origin of life in the solar system. Sheridan Books, Michigan.

    Google Scholar 

  • Plunkett, M.J. and Ellman, J.A. (1997) Combinatorial chemistry and new drugs. Sci. Am., 276, 68–73.

    Article  CAS  Google Scholar 

  • Ponnamperuma, C, Mariner, R. and Sagan, C. (1963a) Formation of adenosine by ultraviolet irradiation of a solution of adenine andribose. Nature, 198, 1199–1200.

    CAS  Google Scholar 

  • Ponnamperuma, C, Sagan, C. and Mariner, R. (1963b) Synthesis of adenosine triphosphate under possible primitive earth conditions. Nature, 199, 222–226.

    CAS  Google Scholar 

  • Rebek, J.J. (1994) Synthetic self-replicating molecules. Sci. Am., July, 34–40.

    Google Scholar 

  • Reid, C. and Orgel, L.E. (1967) Synthesis of sugars in potentially prebiotic conditions. Nature, 216, 455.

    CAS  Google Scholar 

  • Richards, F.F., Konigsberg, W. H., Rosenstein, R. W., and Varga, J. M. (1975) On the specificity of antibodies. Science, 187, 130–137.

    CAS  Google Scholar 

  • Rizzotti M. (1996) Defining Life: the central problem in theoretical biology, University of Padova.

    Google Scholar 

  • Robertson, M.P. and Miller, S.L. (1995) Prebiotic Synthesis of 5-Substituted Uracils: A Bridge Between the RNA World and the DNA-Protein World, Science, 268, 702–705.

    CAS  Google Scholar 

  • Rosenwald, S. (1998) M.Sc. Thesis. The Weizmann Institute of Science, Rehovot, Israel.

    Google Scholar 

  • Rosenwald, S., Kafri, R. and Lancet, D. (2002) Test of a statistical model for molecular recognition in biological repertoires, J. Theor. Biol., 216, 327–36.

    Article  CAS  Google Scholar 

  • Sagan, C. (1963) Primordial ultraviolet synthesis of nucleoside phosphates. In: S.W. Fox (ed.), The origin of prebiological systems, pp. 207–219.

    Google Scholar 

  • Salam, A. (1991) The Role of Chirality in the Origin of Life. Journal of Molecular Evolution, 33, 105–113.

    Article  CAS  Google Scholar 

  • Schlesinger, G. and Miller, S.L. (1983) Prebiotic synthesis in atmospheres containing CH4, CO, and CO2. I. Amino acids. J. Mol. Evol., 19, 376–382.

    Article  CAS  Google Scholar 

  • Schneider-Henriquez, J.E., Denicourt, N. and Fendler, J.H. (1992) Surface Forces in Supported Spherical Lipid Membranes. Langmuir, 8, 3063–3072.

    Article  CAS  Google Scholar 

  • Schopf, J.W., Barghoorn, E.S., Maser, M.D. and Gordon, R.O. (1965) Electron microscopy of fossil bacteria two billion years old. Science, 149, 1365–1357.

    CAS  Google Scholar 

  • Schultz, P.G. and Lerner, R.A. (1995) From molecular diversity to catalysis: lessons from the immune system. Science, 269, 1835–42.

    CAS  Google Scholar 

  • Schwartz, A.W. (1996) Did minerals perform prebiotic combinatorial chemistry? Chemistry and Biology, 3, 515–518.

    Article  CAS  Google Scholar 

  • Schwartz, A.W. and Orgel, L.E. (1985) Template-directed synthesis of novel, nucleic acid-like structures. Science, 228, 585–587.

    CAS  Google Scholar 

  • Sciama, D.W. (1971) Modern Cosmology. Cambridge University Press, Cambridge, UK.

    Google Scholar 

  • Scott, J.K. and Smith, G.P. (1990) Searching for peptide ligands with an epitope library. Science, 249, 386–390.

    CAS  Google Scholar 

  • Segrè, D., Pilpel, Y., Glusman G. and Lancet, D. (1997) Self-Replication and Evolution in Primordial Mutually Catalytic Sets. In: C.B. Cosmovici, S. Bowyer and D. Werthimer (eds.), Astronomical and Biochemical Origins, Editrice Compositori, Bologna, pp. 469–476.

    Google Scholar 

  • Segrè, D. and Lancet, D. (1998) Mutually catalytic amphiphiles: simulated chemical evolution and implications to exobiology, In: J. Chela-Flores and F. Raulin (eds.), Exobiology: Matter, Energy and Information in the Origin and Evolution of Life in the Universe, Kluwer Ac. Pub., 123–131.

    Google Scholar 

  • Segrè, D., Pilpel, Y. and Lancet, D. (1998) Mutual catalysis in sets of prebiotic organic molecules: evolution through computer simulated chemical kinetics, Physica A, 249, Nos. 1–4, 558–564.

    Article  Google Scholar 

  • Segrè, D., Kedem, O., Lancet, D. and Pilpel, Y. (1998a) Graded Autocatalysis Replication Domain (GARD):kinetic analysis of self-replication in mutually catalytic sets, Origins Life Evol. Biosphere, 28, 501–514.

    Article  Google Scholar 

  • Segrè, D. and Lancet, D. (1999) A statistical chemistry approach to the origin of life, Chemtracts-Biochemistry and Molecular Biology, 12(6), 382–397.

    Google Scholar 

  • Segrè, D. and Lancet, D. (2000) Composing Life, EMBO Reports, 1(3), 217–222.

    Article  Google Scholar 

  • Segrè, D., Ben-Eli, D. and Lancet, D. (2000) Compositional genomes: prebiotic information transfer in mutually catalytic non-covalent assemblies, Proc. Natl. Acad. Sci. USA, 97(8), 4112–4117.

    Article  Google Scholar 

  • Segrè, D., Ben-Eli, D. and Lancet, D. (2000a) Prebiotic evolution of amphiphilic assemblies far from equilibrium: from compositional information to sequence-based biopolymers. In: C.B. Cosmovici, S. Bowyer and D. Werthimer (eds.), Astronomical Society of the Pacific Conference Series Vol.213, Sheridan Books, Michigan, pp. 373–378.

    Google Scholar 

  • Segrè, D., Ben-Eli, D., Deamer, D.W. and Lancet, D. (2001) The Lipid World, Origins Life Evol. Biosphere, 31, 119–145.

    Article  Google Scholar 

  • Segrè, D., Shenhav, B., Kafri, R. and Lancet, D. (2001a) The molecular roots of compositional inheritance, J. Theor.Biol., 213, 481–491.

    Article  CAS  Google Scholar 

  • Segrè, D., Vitkup, D. and Church, G.M. (2002) Analysis of optimality in natural and perturbed metabolic networks. Proc. Natl. Acad. Sci. USA, 99, 15112–15117.

    Article  CAS  Google Scholar 

  • Shapiro, R. (1984) The improbability of prebiotic nucleic acid synthesis. Origins Life Evol. Biosphere, 14, 565–570.

    Article  CAS  Google Scholar 

  • Shapiro, R. (2000) A replicator was not involved in the origin of life. IUBMB Life, 49, 173–176.

    Article  CAS  Google Scholar 

  • Shenhav, B., Segrè, D., and Lancet, D. (2002) Mesobiotic emergence: molecular assemblies that self-replicate without biopolymers. Advances in Complex Systems, submitted.

    Google Scholar 

  • Shenhav, B., Kafri, R. and Lancet, D. (2003) The transition from compositional to polymer based replication. Origins Life Evol. Biosphere, in press.

    Google Scholar 

  • Sievers, D. and von-Kiedrowski, G. (1994) Self-replication of complementary nucleotide-based oligomers. Nature, 369, 221–224.

    Article  CAS  Google Scholar 

  • Smith, T. and Morowitz, H. (1982) Between history and physics. J. Mol. Evol., 18, 265–282.

    Article  CAS  Google Scholar 

  • Soai, K., Shibata, T., Morioka, H. and Choji, K. (1995) Asymmetric autocatalysis and amplification of enantiomeric excess of a chiral molecule. Nature, 378, 767–768.

    Article  CAS  Google Scholar 

  • Stadler, P.F., Fontana, W. and Miller, J.H. (1993) Random catalytic reaction networks. Physica D, 63, 378–392.

    Article  Google Scholar 

  • Stadler, P.F., Schnabl, W., Forst, C.V. and Schuster, P. (1995) Dynamics of Small Autocatalytic Reaction Networks — II. Replication, Mutation and Catalysis. Bulletin of Mathematical Biology, 57, 21–61.

    Article  CAS  Google Scholar 

  • Swetina, J. and Schuster, P. (1982) Self-replication with errors — A model for polynucleotide replication. Biophys. Chem., 16, 329–345.

    Article  CAS  Google Scholar 

  • Szathmary, E. (1999) Chemes, Genes, Memes: a revised classification of replicators. Lectures on mathematicsin the life sciences, 26, 1–10.

    Google Scholar 

  • Szathmary, E. and Maynard Smith, J. (1997) From Replicators to Reproducers: the First Major Transitions Leadingto Life. J. Theor. Biol., 187, 555–571.

    Article  CAS  Google Scholar 

  • Szostak, J.W. (1992) In vitro genetics. TIBS, 17, 89–93.

    CAS  Google Scholar 

  • Szostak J.W., Bartel D.P. and Luisi P.L. (2001) Synthesizing life. Nature, 409(Suppl.), 387–90.

    Article  CAS  Google Scholar 

  • Tanford, C. (1978) The hydrophobic effect and the organization of living matter. Science, 200, 1012–1018.

    CAS  Google Scholar 

  • Tjivikua, T., Ballester, P. and Rebek, J. (1990) A self-replicating system. J. Am. Chem. Soc., 112, 1249–1250.

    Article  CAS  Google Scholar 

  • Trimble, V. (1997) Origin of the biologically important elements. Origins Life Evol. Biosphere, 27, 3–21.

    Article  CAS  Google Scholar 

  • Unrau, P.J. and Bartel, D.P. (1998) RNA-catalysed nucleotide synthesis. Nature, 395, 260–263.

    Article  CAS  Google Scholar 

  • Vant-Hull, B., Payano-Baez, A., Davis, R.H. and Gold, L. (1998) The mathematics of SELEX against complex targets. J Mol Biol, 278, 579–97.

    Article  CAS  Google Scholar 

  • Wachtershauser, G. (1988) Before Enzymes and Templates: Theory of Surface Metabolism. Microbiol. Rev., 52, 452–484.

    CAS  Google Scholar 

  • Walde, P., Wick, R., Fresta, M., Mangone, A. and Luisi, P.L. (1994) Autopoietic Self-Reproduction of Fatty Acid Vesicles. J. Am. Chem.Soc, 16, 11649–11654.

    Article  Google Scholar 

  • Wills, P.R., Kauffman, S.A., Stadler, B.M.R. and Stadler, P.F. (1998) Selection Dynamics in Autocatalytic Systems: Templates Replicating Through Binary Ligation. Bull. Math. Biol., 60, 1073–1098.

    Article  CAS  Google Scholar 

  • Wilson, E.O. and Bossert, W.H. (1971) A primer of population biology. Sinauer Assoc, Sunderland, Mass.

    Google Scholar 

  • Wimberly, B.T., Brodersen, D.E., Clemons, W.M.J., Morgan-Warren, R.J., Carter, A.P., Vonrhein, C, Hartsch, T. and Ramakrishnan, V. (2000) Structure of the 30S ribosomal subunit. Nature, 407, 327–339.

    Article  CAS  Google Scholar 

  • Woolfson, A. (2000) Life without genes. Harper Collins, London.

    Google Scholar 

  • Wright, M.C. and Joyce, G.F. (1997) Continuous in vitro evolution of catalytic function. Science, 276, 614–617.

    Article  CAS  Google Scholar 

  • Yarus, M. (1999) Boundaries for an RNA world. Curr. Opin. Chem. Biol., 3, 260–267.

    Article  CAS  Google Scholar 

  • Yockey, H.P. (1992) Information theory and molecular biology. Cambridge University Press.

    Google Scholar 

  • Yockey, H.P. (2000) Origin of Life on Earth and Shannon’s Theory of Communication. Computers and Chemistry, 24, 105–123.

    Article  CAS  Google Scholar 

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Segrè, D., Lancet, D. (2004). Theoretical and Computational Approaches to the Study of the Origin of Life. In: Seckbach, J. (eds) Origins. Cellular Origin, Life in Extreme Habitats and Astrobiology, vol 6. Springer, Dordrecht. https://doi.org/10.1007/1-4020-2522-X_7

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