Overview
- DNA Methylation and Cancer Theraphy focuses on cancer therapy by thoroughly dissecting the basic principles of DNA methylation in cancer from molecular mechanisms to clinical trials.
- The chapters are written by leading experts in the field and are designed to provide the reader with the necessary background to evaluate critically the potential of DNA methylation in cancer therapy.
- Includes supplementary material: sn.pub/extras
Part of the book series: Medical Intelligence Unit (MIUN)
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About this book
NA methylation has bewildered molecular biologists since Hotchkiss discovered it almost six decades ago (Hotchkiss RDJ. Biol Cem 1948; 175:315-332). The fact that the chemical structure of our D genome consists of two components that are covalently bound, the genetic information that is replicated by the DNA replication machinery ana DNA methylation that is maintainea by independent enzymatic machinery, has redictably stimulated the imagination and curiosity of generations of mo Edular biologists. An obvious question was whether DNA methylation was a bearer of additional information to the genetic information and what was the nature of this information? It was tempting to speculate that DNA me thylation applied some form of control over programming of the genome s expression profile. Once techniques to probe the methylation profile of whole genomes as well as specific genes became available, it became clear that DNA methylation patterns are gene and tissue specific and that patterns of gene expression correlate with patterns of methylation. DNA methylation pat terns emerged as the only component of the chemical structure of DNA that exhibited tissue and cell specificity. This data seemingly provided an attrac tively simple explanation for the longstanding dilemma of how could one identical genome manifest itself in so many different forms in multicellular organisms? The DNA methylation pattern has thus become the only known factor to confer upon DNA a unique cellular identity.
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Table of contents (17 chapters)
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Front Matter
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Back Matter
Authors and Affiliations
Bibliographic Information
Book Title: DNA Methylation and Cancer Therapy
Authors: Moshe Szyf
Series Title: Medical Intelligence Unit
DOI: https://doi.org/10.1007/b139080
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag US 2005
Hardcover ISBN: 978-0-306-47848-2Published: 20 January 2005
Softcover ISBN: 978-1-4419-3416-1Published: 06 December 2010
eBook ISBN: 978-0-387-27443-0Published: 03 April 2007
Edition Number: 1
Number of Pages: XV, 239
Number of Illustrations: 67 b/w illustrations, 2 illustrations in colour
Topics: Cancer Research, Oncology, Biotechnology, Biochemistry, general