Overview
- Presents the latest findings on RNA metabolism
- In depth analysis of trypanosome transcription mechanism
- Written by experts in the field
Part of the book series: Nucleic Acids and Molecular Biology (NUCLEIC, volume 28)
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About this book
Trypanosomes are unicellular protozoa of ancient evolutionary origin that are responsible for several tropical diseases, such as African sleeping sickness. Over the last few decades, research in trypanosome biology has revealed many unique and fascinating features, many of which have helped to establish new paradigms in other biological systems. This applies in particular to studies in gene expression and regulation, which benefit enormously from the trypanosome genome projects and from the new genome-wide approaches recently introduced in trypanosome research. This volume covers the most important aspects of biosynthesis, processing, and functions of RNA in trypanosomes, ranging from transcription to RNA editing, mRNA splicing/translation/turnover, processing of transfer and ribosomal RNA, RNA interference, and current transcriptome-wide analyses. Recent progress in RNA-focused research in trypanosomatids promises to yield novel insights into trypanosome-specific features, as well as to reveal in the process new potential therapeutic strategies for combating these parasitic diseases.
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Table of contents (11 chapters)
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Front Matter
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Back Matter
Editors and Affiliations
Bibliographic Information
Book Title: RNA Metabolism in Trypanosomes
Editors: Albrecht Bindereif
Series Title: Nucleic Acids and Molecular Biology
DOI: https://doi.org/10.1007/978-3-642-28687-2
Publisher: Springer Berlin, Heidelberg
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2012
Hardcover ISBN: 978-3-642-28686-5Published: 13 June 2012
Softcover ISBN: 978-3-642-43325-2Published: 18 July 2014
eBook ISBN: 978-3-642-28687-2Published: 12 June 2012
Series ISSN: 0933-1891
Series E-ISSN: 1869-2486
Edition Number: 1
Number of Pages: VI, 274
Topics: Nucleic Acid Chemistry, Eukaryotic Microbiology, Parasitology, Gene Expression