Overview
- Focuses on recent therapeutic applications and future potential for drug discovery
- Features a bench-to-bedside translational approach
- Explores specific diseases and disorders in which GABAB receptors have been implicated
Part of the book series: The Receptors (REC, volume )
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About this book
This new edition presents an up-to-date, comprehensive overview of the GABAB receptor system, including a particular focus on the most recent therapeutic applications and potential. This receptor system has been implicated in several diseases and disorders, including gastroesophageal reflux disease, epilepsy, mood disorders, depression, and alcohol and substance use disorder. The authors, leading researchers in the field, explore a number of approaches, including medicinal chemistry, molecular biology, physiology, and preclinical and clinical pharmacology. The new edition is completely reworked and updated, featuring the latest pharmacological advances on baclofen and positive allosteric modulators.
Keywords
Table of contents (15 chapters)
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Front Matter
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Molecular Biology, Biochemistry, and Functioning of the GABAB Receptor
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Front Matter
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Pharmacology of Baclofen
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Front Matter
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Chemistry and Pharmacology of Positive Allosteric Modulators
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Front Matter
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Miscellanea
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Front Matter
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Editors and Affiliations
About the editor
Giancarlo Colombo is a researcher at the Neuroscience Institute, National Research Council of Italy, Cagliari, Italy.
His research interest is primarily on neurobiology and pharmacology of alcohol use disorder, with focus on the role of GABAB receptor in the control of multiple alcohol-related behaviors and development of GABAB receptor ligands as possible pharmacotherapies for alcohol use disorder.
He has published approximately 240 papers in peer-reviewed journals and about 20 book chapters; he was also the editor of the 2016 volume on GABAB receptor.
He serves as co-chief-editor of the journal Alcohol and Alcoholism.
Bibliographic Information
Book Title: GABAB Receptor
Editors: Giancarlo Colombo
Series Title: The Receptors
DOI: https://doi.org/10.1007/978-3-031-67148-7
Publisher: Humana Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2024
Hardcover ISBN: 978-3-031-67147-0Published: 18 September 2024
Softcover ISBN: 978-3-031-67150-0Due: 02 October 2025
eBook ISBN: 978-3-031-67148-7Published: 17 September 2024
Series ISSN: 1048-6909
Series E-ISSN: 2524-6488
Edition Number: 2
Number of Pages: XX, 341
Number of Illustrations: 32 b/w illustrations, 45 illustrations in colour
Topics: Neurosciences, Neurology