Overview
- Includes clear explanations of fundamentals for correct application
- Contains key notes, experiences and implementation advice from
- Covers relevant and current topics including Drug Metabolizing Enzymes and Transporters
- Includes supplementary material: sn.pub/extras
Part of the book series: Methods in Molecular Biology (MIMB, volume 1113)
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About this book
Drug metabolism and transport are very important facets within the discipline of pharmaceutical sciences, with enzyme kinetic concepts utilized regularly in characterizing and modeling the disposition and elimination of drugs. Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications focuses on very practical aspects of applying kinetic principles to drug metabolizing enzymes and transporters. Divided into five convenient sections, topics include the fundamental principles of enzyme kinetics, the kinetics of oxidative and conjugative drug metabolizing enzymes and drug transporters, modeling approaches for both drug metabolizing enzymes and transporters including novel systems biology approaches, understanding of variability both experimental and interindividual (pharmacogenomic), and case studies that provide real life examples of applying these principles. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics especially suitable for the novice, in some cases step-by-step, readily reproducible protocols, and insights to help with troubleshooting and avoiding known pitfalls with extensive cross referencing to assist in learning.
Authoritative and easily accessible, Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications serves as a very practical teaching tool for novice, non-mathematically trained scientists interested in these fundamental concepts and as an aid for their supervisors in teaching these principles.
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Keywords
Table of contents (24 protocols)
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Fundamentals of Enzyme Kinetics
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Kinetics of Drug Metabolizing Enzymes and Transporters
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Modeling Considerations
Editors and Affiliations
Bibliographic Information
Book Title: Enzyme Kinetics in Drug Metabolism
Book Subtitle: Fundamentals and Applications
Editors: Swati Nagar, Upendra A. Argikar, Donald J. Tweedie
Series Title: Methods in Molecular Biology
DOI: https://doi.org/10.1007/978-1-62703-758-7
Publisher: Humana Totowa, NJ
eBook Packages: Springer Protocols
Copyright Information: Springer Science+Business Media, LLC 2014
Hardcover ISBN: 978-1-62703-757-0Published: 13 February 2014
Softcover ISBN: 978-1-4939-6046-0Published: 27 August 2016
eBook ISBN: 978-1-62703-758-7Published: 12 February 2014
Series ISSN: 1064-3745
Series E-ISSN: 1940-6029
Edition Number: 1
Number of Pages: XVIII, 538
Number of Illustrations: 98 b/w illustrations, 36 illustrations in colour
Topics: Pharmacology/Toxicology, Enzymology