Overview
- Editors:
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Ryan J. Sullivan
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Center for Melanoma, Massachusetts General Hospital Cancer Center, Boston, USA
- Examines BRAF-directed targets in melanoma including molecular biology/signal transduction, molecular diagnostics, immunology, and next-generation analytics
- Highlights and summarizes the unique biological mechanisms of how BRAF-inhibitors work and why they ultimately fail
- Explores combinations of molecular targeted therapy and how molecular targeted therapy may interact with immune-based therapy
- Includes supplementary material: sn.pub/extras
About this book
This volume contains a collection of writings from the leaders in the fields of Molecular Biology and Melanoma Research which will begin to tell the ever-expanding story of the most recent findings, discoveries, and potential of BRAF-directed targets in melanoma. Recent research has shown that BRAF inhibitors are effective for a short period of time, but there is little hope that this drugs as single agents will lead to durable benefit in a majority of patients. Among scientists and researchers who work in drug discovery, there is a lot of interest in the development of molecularly targeted cancer agents. Namely, the identification of a molecular target, the selection of molecules which effectively inhibit this target. What is starkly different about the development of this class of compounds, however, is that the mechanism of action of these agents are not as straightforward as was once previously assumed and the mechanisms of resistance that tumor cells employ to evade complete destruction are unlike any that have been described before. These discoveries in addition to utilization of modern molecular biology techniques have led to a series of hypotheses regarding which other types of molecules could be used in combination with BRAF-inhibitors in hopes of revolutionizing the potential of therapeutics in melanoma.
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Article
Open access
01 October 2022
Table of contents (9 chapters)
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Front Matter
Pages i-viii
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- Suraj Venna, Sekwon Jang, Michael B. Atkins
Pages 1-23
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- Jennifer A. Lo, David E. Fisher
Pages 25-45
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- Melissa A. Wilson, Katherine L. Nathanson
Pages 47-65
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- Jeffrey A. Sosman, Douglas B. Johnson
Pages 67-84
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- Pallavi Kumar, Ryan J. Sullivan
Pages 85-103
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- Dale Han, Keiran SM Smalley
Pages 137-162
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- Zachary A. Cooper, Zain Ahmed, Jennifer A. Wargo
Pages 163-182
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Back Matter
Pages 203-204
Editors and Affiliations
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Center for Melanoma, Massachusetts General Hospital Cancer Center, Boston, USA
Ryan J. Sullivan
About the editor
Dr. Ryan J. Sullivan is affiliated with Massachusetts General Hospital and Dana Farber. His research interests are in the development of novel molecular therapeutic agents for Kaposi sarcoma (KS) and malignant melanoma and the translation of promising preclinical findings into early stage clinical trials. He serves as the co-director of the Eugene Michael Egan Melanoma Translational Research Laboratory at Beth Israel Deaconess Medical Center (BIDMC) and is actively investigating promising biomarkers of response and benefit to immunotherapy and molecular targeted therapy for patients with melanoma.