Overview
- Editors:
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Robert B. Dickson
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Lombardi Cancer Research Center, Georgetown University School of Medicine, USA
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Marc E. Lippman
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Lombardi Cancer Research Center, Georgetown University School of Medicine, USA
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About this book
The current volume represents the fourth over a period of five years in our series on Advances in the Cellular and Molecular Biology of Breast Cancer. The first three volumes were entitled Breast Cancer: Cellular and Molecular Biology, Regulatory Mechanisms in Breast Cancer, and Genes, Oncogenes, and Hormones, respectively. Throughout this series, we have tried to take a broad look at cutting-edge topics in basic science research into breast cancer. This attempt has resulted in a wide range of subject material, including rodent and human model systems, oncogenes, suppressor genes, growth factors, hormones, tumor-host interactions, and determinants of metastases. Since our last volume, research in breast cancer has continued to proceed at an explosive rate. We hope the current volume will provide the reader with some of the excitement felt by the editors and authors as we begin to understand this all-too-common disease. The first section of this book is devoted to the basic processes of proli feration, differentiation, and malignant progression of breast cancer. T.l. Anderson and W.R. Miller lead off with a detailed description of controls on proliferation in the normal human breast and in breast cancer. This chapter strongly emphasizes pathological aspects. The second chapter, by M.R. Stampfer and P. Yaswen, presents a corresponding viewpoint through a presentation of experiments with human mammary epithelial cells in culture. The second section of the book emphasizes the genetic basis for breast cancer onset and malignant progression. Chapter 3, by M.-C. King and S.
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Table of contents (18 chapters)
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Proliferation, Differentiation, and Malignant Progression
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- Thomas J. Anderson, William R. Miller
Pages 3-27
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- Martha R. Stampfer, Paul Yaswen
Pages 29-48
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Genetic Basis for Cancer Onset and Progression
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- Mary-Claire King, Sarah Rowell
Pages 51-62
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- D. Craig Allred, Richard Elledge, Gary M. Clark, Suzanne A. W. Fuqua
Pages 63-77
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- Carlos A. Encarnacion, Suzanne A. W. Fuqua
Pages 97-109
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Growth Factors, Receptors, and Polyamines
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Front Matter
Pages 129-129
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- Ilana Stancovski, Michael Sela, Yosef Yarden
Pages 161-191
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- Mozeena Bano, William R. Kidwell, Robert B. Dickson
Pages 193-208
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Cancer Cell Adhesion, Migration, and Proteolysis
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Front Matter
Pages 227-227
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- Pierre Savagner, Brigitte Boyer, Ana Maria Valles, Jacqueline Jouanneau, Jean Paul Thiery
Pages 229-249
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- Jürgen Behrens, Walter Birchmeier
Pages 251-266
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- Maura C. Kibbey, Keizo Yamamura, Soo Han Jun, Derrick S. Grant, Hynda K. Kleinman
Pages 267-275
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- Seth L. Schor, Anne Marie Grey, Ian Ellis, Ana M. Schor, Anthony Howell, Philip Sloan et al.
Pages 277-298