Skip to main content
SpringerLink
Log in

Chemical Protein Synthesis

  • Book
  • © 2022

Overview

Editors:
  1. Xuechen Li

    1. Department of Chemistry, University of Hong Kong, Hong Kong, SAR, P. R, China

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 2530)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

eBook USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

About this book

This volume provides updated protocols for chemical protein synthesis. Chapters guide readers through development methods, strategies, and applications of protein chemical synthesis. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols.

 

Authoritative and cutting-edge, Chemical Protein Synthesis aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge. 

Similar content being viewed by others

Keywords

Table of contents (16 protocols)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Sulfated Glycoprotein Synthesis

    • Tianlu Li, Peng Peng, Xuefei Huang
    Pages 1-17

  3. Total Chemical Synthesis of a SARS-CoV-2 Miniprotein Inhibitor LCB1

    • Kai Chen, Fei-Qiang Yu, Yan-Ni Zhang, Ge-Min Fang
    Pages 19-31

  4. Serine/Threonine Ligation and Cysteine/Penicillamine Ligation

    • Jiamei Liu, Xuechen Li
    Pages 33-43

  5. Continuous-Flow Synthesis of N-Methylated Peptides via Generation of an Acyl N-Methylimidazolium Cation

    • Hisashi Masui, Shinichiro Fuse
    Pages 45-53

  6. Covalent Reactive Peptides to Block Protein–Protein Interactions and Inhibit Microbe–Host Interaction

    • Yishu Bao, Jiaming Qiu, Jiang Xia
    Pages 55-68

  7. Ynamide-Mediated Synthetic Approach to Thioamide-Substituted Peptides

    • Xue Zhang, Jinhua Yang, Junfeng Zhao
    Pages 69-80

  8. Improved Handling of Peptide Segments Using Side Chain-Based “Helping Hand” Solubilizing Tools

    • Michael T. Jacobsen, Paul Spaltenstein, Riley J. Giesler, Danny Hung-Chieh Chou, Michael S. Kay
    Pages 81-107

  9. General Solution to the Preparation of β-Thiolated/Selenolated Amino Acids Via Visible Light Catalyzed Asymmetric Giese Reaction

    • Hongli Yin, Qingqing Zhou, Mengjie Zheng, Siyao Wang, Ping Wang
    Pages 109-123

  10. Side-Chain Anchoring Strategies for the Synthesis of Peptide Thioesters and Selenoesters

    • Lucas Kambanis, Sameer S. Kulkarni, Richard J. Payne
    Pages 125-140

  11. Preparation of Site-Specific Succinylated Histone Mimics to Investigate Its Impact on Nucleosome Dynamics

    • Yihang Jing, Zheng Liu, Xiang David Li
    Pages 141-157

  12. Protein Synthesis via Activated Cysteine-Directed Protein Ligation

    • Ge Yu, Yuchen Qiao, Lauren R. Blankenship, Wenshe Ray Liu
    Pages 159-167

  13. Sulfonium-Tethered Peptide

    • Yuena Wang, Feng Yin, Zigang Li
    Pages 169-175

  14. PAL-Mediated Ligation for Protein and Cell-Surface Modification

    • Zhen Wang, Dingpeng Zhang, Side Hu, Xiaobao Bi, Julien Lescar, James P. Tam et al.
    Pages 177-193

  15. Development of a Glycoform Library-based Strategy to Decipher the Role of Protein Glycosylation

    • Yaohao Li, Bo Ma, Xue Li, Shiying Shang, Zhongping Tan
    Pages 195-211

  16. A Selenium-based Cysteine Surrogate for Protein Chemical Synthesis

    • Olga Firstova, Vangelis Agouridas, Vincent Diemer, Oleg Melnyk
    Pages 213-239

  17. Removable Backbone Modification (RBM) Strategy for the Chemical Synthesis of Hydrophobic Peptides/Proteins

    • Dong-Liang Huang, Ying Li, Ji-Shen Zheng
    Pages 241-256

  18. Back Matter

    Pages 257-259
    Download chapter PDF
Back to top

Editors and Affiliations

  • Department of Chemistry, University of Hong Kong, Hong Kong, SAR, P. R, China

    Xuechen Li

Bibliographic Information

  • Book Title: Chemical Protein Synthesis

  • Editors: Xuechen Li

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-0716-2489-0

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2022

  • Hardcover ISBN: 978-1-0716-2488-3Published: 29 June 2022

  • Softcover ISBN: 978-1-0716-2491-3Published: 30 June 2023

  • eBook ISBN: 978-1-0716-2489-0Published: 27 June 2022

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XI, 259

  • Number of Illustrations: 20 b/w illustrations, 69 illustrations in colour

  • Topics: Chemistry/Food Science, general

Publish with us

Policies and ethics

Back to top

Search

Navigation