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Humans contain more than 20 Rho type GTPases. This volume not only presents a detailed phylogenetic analysis of Rho proteins, but also discusses the possible origins of the human members. Such an analysis of human Rho GTPases has not previously been attempted.
The book includes an overview of how Rho GTPases become activated which is complemented by an extensive Chapter by Darerca Owen and Helen Mott who unravel the beautiful molecular details given to us by the many structural studies of Rho GTPases.
The key areas currently being investigated in relation to these ubiquitous proteins are described for both in vitro and in vivo systems. These are presented in a format that ensures the reader can approach the topic with minimal background knowledge, while ultimately bringing the subject to the level of an expert. Timely and highly authoritative, this volume illuminates newer findings, particularly as they relate to Rho proteins in vertebrate biology.
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Table of contents (12 chapters)
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Front Matter
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Back Matter
Editors and Affiliations
Bibliographic Information
Book Title: Rho Family GTPases
Editors: Ed. Manser
Series Title: Proteins and Cell Regulation
DOI: https://doi.org/10.1007/1-4020-3462-8
Publisher: Springer Dordrecht
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media B.V. 2005
Hardcover ISBN: 978-1-4020-3461-9Published: 24 June 2005
Softcover ISBN: 978-90-481-6873-6Published: 28 October 2010
eBook ISBN: 978-1-4020-3462-6Published: 30 March 2006
Series ISSN: 1567-2530
Series E-ISSN: 2542-9973
Edition Number: 1
Number of Pages: XIV, 298
Topics: Cell Biology, Enzymology, Biochemistry, general, Proteomics, Cancer Research, Molecular Medicine