Abstract
In radiation therapy, the carbon beams has more advantages with respect to biological properties then a proton beam. The carbon beam has a high linear energy transfer (LET) to the medium and a higher relative biological effectiveness (RBE). To design the spread-out Bragg peak (SOBP) of biological dose for a carbon beam, we propose a practical method using the linear-quadratic (LQ) model and the Geant4-based Monte Carlo simulation code. Various Bragg peak profiles and LETs were calculated for each slice in the target region. To generate an appropriate biological SOBP, we applied a set of weighting factors, which are power functions in terms of energy steps, to each obtained physical dose. The designed biological SOBP showed a uniformity of 1.34%.
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Kim, C.H., Lee, HR., Chang, S. et al. Practical biological spread-out Bragg peak design for a carbon beam. Journal of the Korean Physical Society 67, 1440–1443 (2015). https://doi.org/10.3938/jkps.67.1440
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DOI: https://doi.org/10.3938/jkps.67.1440