Abstract
Chitosan-covered calcium phosphate nanoparticles with the mean dynamic radii of 30 to 130 nm and ζ-potential of +22 ± 4 mV containing timolol and lisinopril are prepared and characterized. These particles are formed by the amorphous phase represented by amorphous calcium phosphate Ca x (PO4) y · zH2O and the crystalline phase represented by hydrated calcium hydrophoshate (brushite) CaHPO4 · 2H2O. The experiments in vivo demonstrated that the inclusion of timolol into calcium phosphate particles covered with chitosan substantially prolonged its effect on the intraocular pressure.
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Abbreviations
- CaPh-particles:
-
calcium phosphate nanoparticles
- IOP:
-
intraocular pressure
- TPP:
-
tripolyphosphate
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Original Russian Text © I.I. Nikolskaya, O.V. Beznos, A.I. Eltsov, I.V. Gachok, N.B. Chesnokova, V.P. Varlamov, O.A. Kost, 2018, published in Vestnik Moskovskogo Universiteta, Seriya 2: Khimiya, 2018, No. 2, pp. 170–176.
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Nikolskaya, I.I., Beznos, O.V., Eltsov, A.I. et al. The Inclusion of Timolol and Lisinopril in Calcium Phosphate Particles Covered by Chitosan: Application in Ophthalmology. Moscow Univ. Chem. Bull. 73, 85–89 (2018). https://doi.org/10.3103/S0027131418020116
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DOI: https://doi.org/10.3103/S0027131418020116