Abstract
Purpose
To investigate a way to prevent postoperative adhesion and fibrosis after hang-back recession surgery, an animal study was carried out to evaluate the effect of mitomycin-C (MMC) and hydroxyurea (HU) on this procedure.
Methods
A prospective, masked-observer, controlled study was performed in New Zealand rabbits. Bilateral hang-back recession of superior and inferior rectus muscle was performed and MMC and HU were applied 5 minutes between muscle-sclera and muscle-conjunctiva with a sponge (groups I and II), whereas other eyes of these rabbits were reserved as control group (group III). In this study, the degree of postoperative adhesion, fibrosis, and vascularization of conjunctiva were recorded and compared.
Results
In groups I and II, the records of postoperative adhesion and fibrosis were found to be significantly lower than in the control group. The new insertion line was more regular in groups I and II. Histopathological examination of these muscles revealed decreased fibrosis of perimuscular connective tissue in eye groups I and II.
Conclusion
This article suggests that HU and MMC can help to reduce postoperative adhesion, fibrosis, and vascularization of conjunctiva in rabbits that underwent hang-back recession surgery.
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References
Dunlap EA. Surgery of muscle adhesion and effects of multiple operations. Br J Ophthalmol. 1974;58:307–312.
Cruz OA, Matkovich L. Effects of intraoperative topical mitomycin-C on strabismus surgery in the rabbit: a preliminary study. Ophthalmic Surg. 1995;26:237–240.
Othsuki H, Hasebe S, Okuda Y, Ogou T. Is mitomycin-C effective in preventing muscle migration after hang-back recession in a rabbit model?. Ophthalmologica 1997;211:373–379.
Hwang JM, Chang BL. Combined effect of polytetrafluoroethylene and 5-fluorouracil on delayed adjustable strabismus surgery. J Pediatr Ophthalmol Strabismus. 2000;37:163–167.
Yücel I, Bager G, Duranoglu Y, et al. The effect of hydroxyurea on rabbit subconjunctival fibroblast culture and use of hydroxyurea in rabbits after glaucoma filtration surgery. Ophthalmologica. 1999; 213:311–319.
Hwang JM, Chang BL. Combined effect of intercede and 5-fluorouracil on delayed adjustable strabismus surgery. Br J Ophthalmol. 1999;83:788–791.
Searl SS, Metz HS, Lindahl KJ. The use of sodium hyaluronate as a biologic sleeve in strabismus surgery. Ann Ophthalmol. 1987;19:259–268.
Shodika MF. Use of silicone sheet for delayed adjustable strabismus surgery. Ophthalmic Surg. 1993;24:486–488.
Elsas FJ, Gowda DC, Urry DW. Synthetic polypepetide sleeve for strabismus surgery. J Pediatr Ophthalmol Strabismus. 1992;29:284–286.
Huran JM, Chang BL. Ue of physical barriers for delayed adjustable strabismus surgery: the effect of intercede and polyglactin 910 mesh. Br J Ophthalmol. 1996;80:759–762.
Clorfeine GS, Parker WT. Use of healon in eye muscle surgery with adjustable sutures. Ann Ophthalmol. 1987;19:215–217.
Oh SY, Park DW, Chang BL. The effect of mitomycin-C on the healing process in rabbit extraocular muscle surgery. Ophthalmologic Surg Lasers. 1999;30:305–309.
Cruz OA. Evaluation of mitomycin to limit postoperative adhesions in strabismus surgery. J Pediatr Ophthalmol Strabismus. 1996;33:89–92.
Khaw PT, Doyle JW, Sherwood MB, et al. Effects of intraoperative 5-fluorouracil or mitomycin C on glaucoma filtration surgery in the rabbit. Ophthalmology 1993;100:367–372.
Mora JS, Sprunger DT, Helveston EM, Evan AP. Intraoperative sponge 5-fluorouracil to reduce postoperative scarring in strabismus surgery. J AAPOS. 1997;1:92–97.
Yaacobi Y, Hamed LM, Kaul KS, Fanous MM. Reduction of postoperative adhesions secondary to strabismus surgery in rabbits. Ophthalmic Surg. 1992;23:123–128.
Nemet P, Stolovitch C. Delayed reattachment of extraocular muscle. Binoc Vis. 1989;4:23–22.
Oelsner G, Graebe RA, Pan S, et al. Chondroitin sulphate: a new intraperitoneal treatment for postoperative adhesion prevention in the rabbit. J Reprod Med. 1987;32:812–814.
Glaubiger D, Ramu A. Antitumor antibiotics. In: Chabner BA, ed. Pharmacologie Principles of Cancer Treatment. Philadelphia, WB Saunders, 1982: pp. 407–410.
Chabner AC, Allegra JC, Curt AG, Calebresi P. Antineoplastic agents. In: Gilman AG, Rall TW, Nies AS, Taylor P, eds. The Pharmacological Basis of Therapeutics. New York, Pergamon, 1996; pp. 1233–1287.
Knaap A, Heuer DK, Stern GA, et al. Serious corneal complications of glaucoma filtering surgery with postoperative 5-fluorouracil. Am J Ophthalmol. 1987;103:183–187.
Smith S, D’Amore PA, Dreyer EB. Comperative toxicity of mitomycin C and 5-fluorouracil in vitro. Am J Ophthalmol. 1994;118:332–337.
Brooks SE, Riberio GB, Archer SM, et al. Fat adherence syndrome treated with intraoperative mitomycin C: a rabbit model. J Pediatr Ophthalmol Strabismus. 1996;33:21–27.
Andreo LK, Uyemura MJ, Enzenauer RW. 5-fluorouracil reduces scarring after strabismus surgery. J Pediatr Ophthalmol Strabismus. 1997;34:107–110.
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The authors have stated that they do not have a significant financial interest or other relationship with any product manufacturer or provider of services discussed in this article. The authors also do not discuss the use of off-label products, which include unlabeled, unapproved, or investigative products or devices.
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Duranoğlu, Y., Gözkaya, O. & Altin, M. The effect of hydroxyurea and mitomycin-C to prevent postoperative adhesion and fibrosis after hang-back recession in rabbits. Ann Ophthalmol 37, 105–109 (2005). https://doi.org/10.1385/AO:37:2:105
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DOI: https://doi.org/10.1385/AO:37:2:105