Abstract
The biological effect of iron nanoparticles with a size of 20–40nm obtained by the plasmochemical method are studied. An antibacterial effect on antibiotic resistant strains of Pseudomonas aeruginosa and Staphylococcus aureus is found at concentrations of iron nanoparticles in a range of 0.1–10 mg/mL. The toxic effect of iron nanoparticles administered this way is revealed in male mice, which is manifested in a change in biochemical parameters of carbohydrate, lipid, and protein metabolisms.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
A. P. Kaplun, D. A. Bezrukov, A. V. Rodina, V. I. Popenko, and V. I. Shvets, “Modern nanomedicine,” Nanotekhnika, No. 2, 3–8 (2007).
C.-H. Yu, W. Oduro, Kin Tam, and E. S. C. Tsang, “Some applications of nanoparticles,” in Handbook of Metal Physics, Ed. by J. A. Blackman (Elsevier, 2008), Vol. 5, Chapter 10, pp. 365–380.
I. P. Arsent’eva, E. S. Zotova, G. E. Folmanis, et al., “Validation of metals nanoparticles used as a biologically active products,” Nanotekhnika, No. 2, 72–77 (2007).
M. I. Baraton, “Synthesis, functionalization, and surface treatment of nanoparticles,” Am. Sci. Los-Angeles, 234–236 (2002).
R. A. Freitas, “Nanotechnology, nanomedicine and nanosurgery (invited editorial),” Int. J. Surgery, No. 3, 1–4 (2005).
R. A. Freitas, “Pharmacytes: an ideal vehicle for targeted drug delivery,” J. Nanosci. Nanotechnol., No. 6, 2769–2775 (2006).
E. K. Baranova, A. A. Revina, L. I. Voino, and V. I. Gorbatyuk, “The way to compare Ag ions and nanoparticles impact onto cells of yeasts and E. coli,” in Proc. 1st Russian Sci.-Methodological Seminar “Nanoparticles in Nature. Nanotechnologies for Their Generation Applied to Biological Systems (Moscow, 2003), pp. 53–60.
E. M. Blagitko, “Are Ag nanopreparations efficient as antibacterial and antiviral drugs in Russian medical practice?,” in Proc. Sci.-Pract. Conf. with International Participation “Nanotechnologies and Nanomaterials for Biology and Medicine” (Novosibirsk, 2007), Part 2, pp. 36–39.
A. A. Angel’skii, T. V. Lavrikova, P. P. Rodionov, G. V. Odegova, and V. A. Burmistrov, “The way to treat patients with osteomyelitis and septic wound by microsurgical technique and Ag nanopreparates,” in Proc. Sci.-Pract. Conf. with International Participation “Nanotechnologies and Nanomaterials for Biology and Medicine” (Novosibirsk, 2007), Part 2, pp. 7–13 [in Russian].
V. S. Bespalov and D. V. Vulichnaya, “Nanostructured chitosan gels vasna→govasna with Ag for wounds and burns healing. Application experience,” in Proc. Sci.-Pract. Conf. with International Participation “Nanotechnologies and Nanomaterials for Biology and Medicine” (Novosibirsk, 2007), Part 2, pp. 20–23 [in Russian].
N. A. Vorontsova, P. P. Rodionov, G. V. Odegova, V. A. Burmistrov, and O. G. Simonova, “Cluster silver for treating ear nose throat diseases in children,” in Proc. Sci.-Pract. Conf. with International Participation “Nanotechnologies and Nanomaterials for Biology and Medicine” (Novosibirsk, 2007), Part 2, pp. 70–76 [in Russian].
N. N. Glushchenko, T. A. Baitukalov, O. A. Bogoslovskaya, and I. P. Ol’khovskaya, “Wound healing properties of drugs based on metals nanoparticles,” in Proc. Sci.-Pract. Conf. with International Participation “Nanotechnologies and Nanomaterials for Biology and Medicine” (Novosibirsk, 2007), Part 2, pp. 76–80 [in Russian].
A. V. Kolesnichenko, M. A. Timofeev, and M. V. Protopopova, “Nanometrials toxicity: 15 years of research,” Ross. Nanotekhnol. 3 (3–4), 54–61 (2008).
G. G. Onishchenko, Directive under 31.10.2007 no. 79 “On conception related to toxicological researches, risk estimation methods, methods for nanomaterials identifying and quantitative determination according to the Russian Federal Law no 52-FZ under 30.03.1999 “On nation sanitary epidemiological health”, in Collection of Russian Laws (1999), 14, Art. 1650; (2002), 1(part 1), Art.1; (2003), 2, Art. 167; 27 (Part 1), Art. 2700; (2004), 35, Art. 3607; (2005), 19, Art.1752; (2006), 1, Art. 10; (2006), 52 (Part 1), Art. 5498; (2007), 1 (Part 1), Art. 21; (2007), 1 (Part 1), Art. 29; (2007), 27, Art. 3213; (2007), 46, Art. 554.
H. Kang, L. Wang, M. O’Donoghue, Y. C. Cao, and W. Tan, “Nanoparticles for biosensors,” Opt. Biosens., No. 2, 583–621 (2008).
T. C. Long, J. Tajuba, P. Sama, N. Saleh, C. Swartz, et al., “Nanosize titanium dioxide stimulates reactive oxygen species in brain microglia and damages neurons in vitro,” Environ. Health Perspect. 115 (11), 1631–1637 (2007).
I. P. Kaura, R. Bhanarib, S. Bhanarib, and V. Kakkara, “Potential of solid lipid nanoparticles in brain targeting,” J. Control. Release 127 (2), 97–109 (2008).
Laboratory Biosafety Manual (World, Health Organization, Geneva, 1983).
N. N. Karkishchenko and S. V. Grachev, Handbook on Laboratory Animals and Alternative Models in Biomedical Researches, Ed. by N. N. Karkishchenko and S. V. Grachev (Profil’-2C, Moscow, 2010) [in Russian].
A. I. Karpishchenko, Medical Laboratory Technologies and Diagnostics. Handbook (Intermedika, St. Petersburg, 1999) [in Russian].
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Borodulin, V.B., Goroshinskaya, I.A., Kachesova, P.S. et al. Study of the biological effect of iron nanoparticles. Nanotechnol Russia 10, 268–277 (2015). https://doi.org/10.1134/S1995078015020056
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1995078015020056