Abstract
We studied the effects of oral administration of ω-3 polyunsaturated fatty acids (PUFAs) on behavioral characteristics and immunohistochemical, morphological, and biochemical parameters in hippocampi of mice with experimental neuroinflammation. We found that animals with neuroinflammation that were treated with ω-3 PUFAs had higher parameters of locomotor activity and working memory compared to the vehicle-treated group. The immunohistochemical analysis showed that activation of glial cells was less significant in ω-3 PUFA-treated animals than in vehicle-treated animals with neuroinflammation. An increase in the production of pro-inflammatory cytokine IL-1ß and malonic dialdehyde, a marker of lipid peroxidation, in the hippocampus was less pronounced than in the vehicle-treated group. Thus, we assume that the normalization of locomotor activity and working memory after PUFA administration reduce microglial and astroglial activation, the intensity of neuroinflammation and oxidative stress and, as a consequence, prevent changes in the physicochemical characteristics of cellular and mitochondrial membranes.
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Fleminger, S., Brain Impairment, 2013, vol. 14, pp. 2–4.
Informatsionnyi Byulleten’ VOZ, 2015, no. 362.
Zyryanov, S.K. and Belouso, Yu.B., Sotsial’naya i Klinicheskaya Psikhiatriya, 2011, vol. 21, no. 3, pp. 74–76.
Noetzli, M. and Eap, C.B., Clinical Pharmacokinetics, 2013, vol. 52, no. 4, pp. 225–241.
Salmina, A.B., Komleva, Yu.K., Kuvacheva, N.V., Lopatina, O.L., Pozhilenkova, E.A., Gorina, Ya.V., Gasymly, E.D., Panina, Yu.A., Morgun, A.V., and Malinovskaya, N.A., Vestnik Rossiiskoi Akademii Meditsinskikh Nauk, 2015, vol. 70, no. 1, pp. 17–25.
Schuchardt, J.P., Huss, M., Stauss-Grabo, M., and Hahn, A., European Journal of Pediatrics, 2010, vol. 169, no. 2, pp. 149–164.
Devore, E.E., Grodstein, F., van Rooij, F.J., Hofman, A., Rosner, B., Stampfer, M.J., and Breteler, M.M., Am. J. Clin. Nutr., 2009, vol. 90, no. 1, pp. 170–176.
Okubo, H., Miyake, Sasaki, S., Murakami, K., Tanaka, K., Fukushima, W., and Nagai, M., Eur. J. Neurol., 2012, vol. 19, no. 5, pp. 681–688.
Swanson, D., Block, R., and Mousa, S.A., Adv. Nutr., 2012, vol. 3, no. 1, pp. 1–7.
Salem, N., Jr. and Eggersdorfer, M., Curr. Opin. Clin. Nutr. Metab. Care, 2015, vol. 18, no. 2, pp. 147–154.
Farooqui, A.A., Phytochemicals, Signal Transduction, and Neurological Disorders, New York: Springer, 2012, pp. 57–81.
Lysenko, L.V., Kim, J., Henry, C., Tyrtyshnaia, A., Kohnz, R.A., Madamba, F., and Kleschevnikov, A.M., PLoS One, 2014, vol. 9, no. 12, e114521.
Knowles, J.K., Simmons, D.A., Nguyen, T.V.V., Vander, GriendL., Xie, Y., Zhang, H., and Longo, F.M., Neurobiol. Aging, 2013, vol. 34, no. 8, pp. 2052–2063.
Bevins, R.A. and Besheer, J., Nat. Protocols, 2006, vol. 1, no. 3, pp. 1306–1311.
Wasowicz, W., Neve, J., and Peretz, A., Clin. Chem., 1993, vol. 39, no. 12, pp. 2522–2526.
Folch, J. and Sloane-Stanley, G.H., J. Biol. Chem., 1957, vol. 226, no. 1, pp. 497–509.
Graf, B.A., Duchateau, G.S., and Patters, J.E., Prostaglandins Leukot. Essent. Fatty Acids, 2010, vol. 83, no. 2, pp. 89–96.
Rapoport, S.I., Rao, J.S., and Igarashi, M., Prostaglandins Leukot. Essent. Fatty Acids, 2007, vol. 77, no. 5, pp. 251–261.
Dervisoglu, E., HIPPOKRATIA, 2012, vol. 16, no. 2, pp. 143–148.
Assies, J., Mocking, R.J.T., Lok, A., Ruhe, H.G., Pouwer, F., and Schene, A.H., Acta Psychiat. Scand., 2014, vol. 130, no. 3, pp. 163–180.
Turrin, N.P. and Rivest, S., J. Neurosci., 2006, vol. 26, no. 1, pp. 143–151.
Serhan, C.N., Chiang, N., and Van Dyke, T.E., Nat. Rev. Neurosci., 2008, vol. 8, no. 5, pp. 349–361.
Gosselin, D. and Rivest, S., Brain Behav. Immun., 2007, vol. 21, no. 3, pp. 281–289.
Wall, R., Ross, R.P., Fitzgerald, G.F., and Stanton, C., Nutr. Rev., 2010, vol. 68, no. 5, pp. 280–289.
Wilkinson, B.L. and Landreth, G.E., J. Neuroinflammation, 2006, vol. 3, no. 1, p. 30.
Lee, H.S., Barraza-Villarreal, A., Hernandez-Vargas, H., Sly, P.D., Biessy, C., Ramakrishnan, U., and Herceg, Z., Am. J. Clin. Nutr., 2013, vol. 98, no. 2, pp. 480–487.
Lynch, A.M., Moore, M., Craig, S., Lonergan, P.E., Martin, D.S., and Lynch, M.A., J. Biol. Chem., 2003, vol. 278, no. 51, pp. 51075–51084.
Tyrtyshnaia, A.A., Lysenko, L.V., Madamba, F., Manzhulo, I.V., Khotimchenko, M.Y., and Kleschevnikov, A.M., J. Neuroinflammation, 2016, vol. 13, no. 1, p. 283.
Hashimoto, M., Tanabe, Y., Fujii, Y., Kikuta, T., Shibata, H., and Shido, O., J. Nutr., 2005, vol. 135, no. 3, pp. 549–555.
Wall, R., Ross, R.P., Fitzgerald, G.F., and Stanton, C., Nutr. Rev., 2010, vol. 68, no. 5, pp. 280–289.
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Original Russian Text © A.A. Tyrtyshnaia, I.V. Manzhulo, 2018, published in Neirokhimiya, 2018, Vol. 35, No. 2, pp. 170–182.
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Tyrtyshnaia, A.A., Manzhulo, I.V. The Effect of Omega-3 Polyunsaturated Fatty Acids on Neuroinflammation in the Hippocampus. Neurochem. J. 12, 168–179 (2018). https://doi.org/10.1134/S1819712418020125
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DOI: https://doi.org/10.1134/S1819712418020125