Abstract
Reaction of N-arylacetoacetamides with aromatic aldehydes in the presence of piperidine in ethanol afforded N,N′,2-triaryl-6-hydroxy-6-methyl-4-oxocyclohexane-1,3-dicarboxamides. The latter reacted with p-toluidine leading to the formation of dehydration products. Reactions of N,N′,2-triaryl-6-hydroxy-6-methyl-4-oxocyclohexane-1,3-dicarboxamides with hydrazine hydrate and cyanoacetic acid hydrazide gave rise to tetrahydroindazoles. Some of the obtained compounds showed antimicrobial activity.
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Original Russian Text © V.L. Gein, T.F. Odegova, A.N. Yankin, N.V. Nosova, 2015, published in Zhurnal Obshchei Khimii, 2015, Vol. 85, No. 1, pp. 51–57.
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Gein, V.L., Odegova, T.F., Yankin, A.N. et al. Synthesis of N,N′,2-triaryl-6-hydroxy-6-methyl-4-oxocyclohexane-1,3-dicarboxamides and their reactions with p-toluidine and hydrazine hydrate. Russ J Gen Chem 85, 46–52 (2015). https://doi.org/10.1134/S1070363215010089
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DOI: https://doi.org/10.1134/S1070363215010089