Abstract
Glycogen phosphorylase as a potential target for design of new drugs for the treatment of diabetes mellitus type 2, its main role and functions, as well as the ligands that bind to different sites of the enzyme are discussed in this review.
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Abbreviations
- GP:
-
glycogen phosphorylase
- HGP:
-
hepatic glucose production
References
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Original Russian Text © A.A. Spasov, N.I. Chepljaeva, E.S. Vorob’ev, 2016, published in Bioorganicheskaya Khimiya, 2016, Vol. 42, No. 2, pp. 150–159.
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Spasov, A.A., Chepljaeva, N.I. & Vorob’ev, E.S. Glycogen phosphorylase inhibitors in the regulation of carbohydrate metabolism in type 2 diabetes. Russ J Bioorg Chem 42, 133–142 (2016). https://doi.org/10.1134/S1068162016020138
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DOI: https://doi.org/10.1134/S1068162016020138