Abstract
Multiliposome biodegradable conjugates have been obtained via electrostatic binding of a liposome-polylysine complex with micelles formed from a polylactide-poly(ethylene glycol) di- or triblock copolymer. It has been shown that the integrity of liposomes in conjugates is retained. Of special interest is a conjugate based on a polylactide-poly(ethylene glycol) diblock copolymer that exhibits stability in a physiological solution with 0.15 mol/L NaCl, but degrades in the presence of proteolytic enzymes. This fact allows the suggestion that the conjugate will be eliminated from the body after its transport function is completed. The results may be used to create biodegradable liposome containers for drug encapsulation and delivery.
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Original Russian Text © A.A. Efimova, S.N. Chvalun, A.I. Kulebyakina, E.V. Kozlova, A.A. Yaroslavov, 2016, published in Vysokomolekulyarnye Soedineniya. Ser. A, 2016, Vol. 58, No. 2, pp. 146–151.
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Efimova, A.A., Chvalun, S.N., Kulebyakina, A.I. et al. Synthesis and properties of conjugates involving liposomes, a linear polymer, and the micelle of a polylactide-poly(ethylene glycol) block copolymer. Polym. Sci. Ser. A 58, 172–176 (2016). https://doi.org/10.1134/S0965545X16020061
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DOI: https://doi.org/10.1134/S0965545X16020061