Abstract
Two soil isolates, Arthrobacter sp. KNK168 and Pseudomonas sp. KNK425, aminated 3,4-dimethoxyphenylacetone in presence of sec-butylamine as an amino donor to yield 3,4-dimethoxyamphetamine (DMA) with different enantioselectivities. The former gave (R)-DMA (>99% e.e.) and the latter the (S)-isomer (>99% e.e.).
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Iwasaki, A., Yamada, Y., Ikenaka, Y. et al. Microbial synthesis of (R)- and (S)-3,4-dimethoxyamphetamines through stereoselective transamination. Biotechnology Letters 25, 1843–1846 (2003). https://doi.org/10.1023/A:1026229610628
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DOI: https://doi.org/10.1023/A:1026229610628