Abstract
This review analyzes data on the biological role of 3α-hydroxysteroid dehydrogenase (3α-HSD) in animal and human tissues and describes its main characteristics, mechanism of action, and regulation of activity. Based on published data, a scheme for the actions of androgen, progestin, and glucocorticoids involving the participation of 3α-HSD is proposed. According to this scheme, in the mechanism of steroid action 3α-HSD not only regulates the concentration of the main effector androgen, 5α-dihydrotestosterone, in target cells, but also switches androgen, progestin, and glucocorticosteroid genomic activity to non-genomic activity.
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Degtiar, W.G., Kushlinsky, N.E. 3α-Hydroxysteroid Dehydrogenase in Animal and Human Tissues. Biochemistry (Moscow) 66, 256–266 (2001). https://doi.org/10.1023/A:1010291527744
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DOI: https://doi.org/10.1023/A:1010291527744