Abstract
The previous study of the 25 hemagglutinin-esterase (HE) glycoprotein genes of influenza C viruses identified four discrete lineages represented by C/Yamagata/26/81, C/Aichi/1/81, C/Aomori/74 and C/Mississippi/80, respectively. Here we compared the M gene sequence among the 24 viruses isolated between 1964 and 1991. A phylogenetic analysis showed that these genes have evolved into three distinct lineages. Lineage I included most of viruses with the HE genes of C/Yamagata/26/81-related lineage. The predominant members of lineage II were viruses having the HE genes of either C/Aichi/1/81- or C/Mississippi/80-related lineage. Lineage III contained only C/Aomori/74. Phylogenetic positions of several strains (C/Yamagata/64, C/Kanagawa/1/76, C/Miyagi/77 and C/Nara/1/85) were different between the M and HE gene trees, suggesting that they are reassortants. Furthermore, phylogenetic relationships between C/Mississippi/80-like and C/Aichi/1/81-like viruses were much closer for the M gene than the HE gene, raising the possibility that these two virus groups are genetically related by a reassortment event. Nucleotide changes in the M genes occurred at about 7% positions with a uniform distribution throughout the molecules. However, the predicted amino acid sequence of the matrix protein (M1) was conserved almost completely among the isolates analyzed. The amino acid sequence of the second protein (CM2) encoded by M gene was also highly conserved, but was more divergent than the M1 protein sequence, suggesting that the two M gene products are evolving differently in response to selective pressures or structural and functional constraints.
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References
Yamashita M., Krystal M., and Palese P., J Virol 62, 3348–3355, 1988.
Hongo S., Sugawara K., Nishimura H., Muraki Y., Kitame F., and Nakamura K., J Gen Virol 75, 3503–3510, 1994.
Hongo S., Sugawara K., Muraki Y., Kitame F., and Nakamura K., J Virol 71, 2786–2792, 1997.
Sugrue R., and Hay A.J., Virology 180, 617–624, 1991.
Pinto L.H., Holsinger L.J., and Lamb R.A., Cell 69, 517–528, 1992.
Buonagurio D.A., Nakada S., Desselberger U., Krystal M., and Palese P., Virology 146, 221–232, 1985.
Buonagurio D.A., Nakada S., Fitch W.M., and Palese P., Virology 153, 12–21, 1986.
Kawamura H., Tashiro M., Kitame F., Homma M., and Nakamura K., Virus Res 4, 275–288, 1986.
Muraki Y., Hongo S., Sugawara K., Kitame F., and Nakamura K., J Gen Virol 77, 673–679, 1996.
Gao P., Hongo S., Muraki Y., Sugawara K., Nishimura H., Kitame F., and Nakamura K., J Gen Virol 75, 3619–3622, 1994.
Gao P., Hongo S., Kimura H., Muraki Y., Sugawara K., Kitame F., Numazaki Y., Suzuki H., and Nakamura K., J Gen Virol 77, 1489–1492, 1996.
Bean W.J., Sriram G., and Webster R.G., Anal Biochem 102, 228–232, 1980.
Sanger F., Nicklen S., and Coulson A.R., Proc Natl Acad Sci USA 74, 5463–5467, 1977.
Felsenstein J., Cladistics 5, 164–166, 1989.
Fitch W.M., Syst Zool 20, 406–416, 1971.
Ohyama S., Adachi K., Sugawara K., Hongo S., Nishimura H., Kitame F., and Nakamura K., Epidemiol Infect 108, 353–365, 1992.
Ito T., Gorman O.T., Kawaoka Y., Bean W.J., and Webster R.G., J Virol 65, 5491–5498, 1991.
Nei M. and Gojobori T., Mol Biol Evol 3, 418–426, 1986.
Nishimura H., Sugawara K., Kitame F., Nakamura K., Katsushima N., Moriuchi H., and Numazaki Y., J Gen Virol 70, 1653–1661, 1989.
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Tada, Y., Hongo, S., Muraki, Y. et al. Evolutionary Analysis of Influenza C Virus M Genes. Virus Genes 15, 53–59 (1997). https://doi.org/10.1023/A:1007915215958
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DOI: https://doi.org/10.1023/A:1007915215958