Abstract
Purpose
To evaluate the overall somatic involvement in patients with eating disorders (EDs).
Methods
The medical records of 206 patients (age 15–56 years, 96.1 % females) with diagnosis of anorexia nervosa (AN, n = 63, 30.6 %), bulimia nervosa (BN, n = 78, 37.9 %), or eating disorder not otherwise specified (EDNOS, n = 65, 31.6 %) were analyzed. A cumulative score of clinical severity (SCS) was computed according to the presence of physical, instrumental, and laboratory abnormalities, as well as to their prognostic impact. Based on the tertile distribution of SCS, three levels of severity were defined: low, medium, and high.
Results
A medium/high level of severity was found in 63 % of the whole sample, 89 % of AN, 49 % of BN, and 55 % of EDNOS. In the whole sample, the risk of medium/high SCS was significantly and inversely related to the body mass index (BMI) and to the lifetime minimum BMI. The severity level was significantly and positively associated with diagnosis of AN, duration of amenorrhea ≥1 year, and presence of ED-related symptoms. EDNOS patients showed a higher risk for increased SCS than BN patients, although not significantly.
Conclusion
The non-negligible frequency of a relevant somatic involvement in patients with EDNOS suggests that a transdiagnostic scoring system might be helpful to identify ED cases at risk of medical complications.
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References
Mehler PS, Krantz M (2003) Anorexia nervosa medical issues. J Womens Health (Larchmt) 12:331–340
Misra M, Aggarwal A, Miller K et al (2004) Effects of anorexia nervosa on clinical, haematologic, biochemical and bone density parameters in community-dwelling adolescent girls. Pediatrics 114:1574–1583
American Psychiatric Association (2006) Practice guidelines for the treatment of patients with eating disorders, 3rd edn. Washington (DC). Available online www.guidelines.gov/content.aspx?id=9318
Mehler PS (2011) Medical complications of bulimia nervosa and their treatments. Int J Eat Disord 44:95–104
Hebebrand J, Bulik CM (2011) Critical appraisal of the provisional DSM-5 criteria for anorexia nervosa and an alternative proposal. Int J Eat Disord 44:665–678
Fichter MM, Quadflieg N (2007) Long-term stability of eating disorder diagnoses. Int J Eat Disord 40(Suppl):S61–S66
Fairburn CG, Bohn K (2005) Eating disorder NOS (EDNOS): an example of the troublesome “not otherwise specified” (NOS) category in DSM-IV. Behav Res Ther 43:691–701
Fairburn CG, Cooper Z (2007) Thinking afresh about the classification of eating disorders. Int J Eat Disord 40(Suppl):S107–S110
Dunn EC, Geller J, Brown KE et al (2010) Addressing the EDNOS issue and improving upon the utility of DSM-IV: classifying eating disorders using symptom profiles. Eur Eat Disord Rev 18:271–280
Roberto CA, Steinglass J, Mayer LE et al (2008) The clinical significance of amenorrhea as a diagnostic criterion for anorexia nervosa. Int J Eat Disord 41:559–563
Attia E, Roberto CA (2009) Should amenorrhea be a diagnostic criterion for anorexia nervosa? Int J Eat Disord 42:581–589
Williamson DA, Gleaves DH, Stewart TM (2005) Categorical versus dimensional models of eating disorders: an examination of the evidence. Int J Eat Disord 37:1–10
Bulik CM, Sullivan PF, Kendler KS (2000) An empirical study of the classification of eating disorders. Am J Psychiatry 157:886–895
Wilfley DE, Bishop ME, Wilson GT et al (2007) Classification of eating disorders: toward DSM-V. Int J Eat Disord 40:S123–S129
Walsh BT, Sysko R (2009) Broad categories for the diagnosis of eating disorders (BCD-ED): an alternative system for classification. Int J Eat Disord 42:754–764
Fairburn CG, Cooper Z (2011) Eating disorders, DSM-5 and clinical reality. Br J Psychiatry 198:8–10
American Psychiatric Association. (2000) Diagnostic and statistical manual of mental disorders 4th edn, text rev. doi:10.1176/appi.books.9780890423349
Lewiecki EM, Gordon CM, Baim S et al (2008) International society for clinical densitometry 2007 adult and pediatric official positions. Bone 43:1115–1121
Kollai M, Bonyhay I, Jokkel G et al (1994) Cardiac vagal hyperactivity in adolescent anorexia nervosa. Eur Heart J 15:1113–1118
Miller KK, Grinspoon SK, Champa J et al (2005) Medical findings in outpatients with anorexia nervosa. Arch Intern Med 165:561–566
Palla B, Litt I (1988) Medical complications of eating disorders in adolescents. Pediatrics 81:613–623
Frölich J, von Gontard A, Lehmkuhl G et al (2001) Pericardial effusions in anorexia nervosa. Eur Child Adolesc Psychiatry 10:54–57
Polli N, Blengino S, Moro M et al (2006) Pericardial effusion requiring pericardiocentesis in a girl with anorexia nervosa. Int J Eat Disord 39:609–611
De Simone G, Scalfi L, Galderisi M et al (1994) Cardiac abnormalities in young women with anorexia nervosa. Br Heart J 71:287–292
Mont L, Castro J, Herreros B et al (2003) Reversibility of cardiac abnormalities in adolescents with anorexia nervosa after weight recovery. J Am Acad Child Adolesc Psychiatry 42:808–813
Facchini M, Sala L, Malfatto G et al (2006) Low-K+ dependent QT prolongation and risk for ventricular arrhythmia in anorexia nervosa. Int J Cardiol 106:170–176
Powers PS, Tyson IB, Stevens BA et al (1995) Total body potassium and serum potassium among eating disorder patients. Int J Eat Disord 18:269–276
Agrawal V, Agarwal M, Joshi SR et al (2008) Hyponatremia and hypernatremia: disorders of water balance. J Assoc Physicians India 56:956–964
Hutter G, Ganepola S, Hofmann WK (2009) The hematology of anorexia nervosa. Int J Eat Disord 42:293–300
Lambert M, Hubert C, Depresseux G et al (1997) Hematological changes in anorexia nervosa are correlated with total body fat mass depletion. Int J Eat Disord 21:329–334
Abella E, Feliu E, Granada I et al (2002) Bone marrow changes in anorexia nervosa are correlated with the amount of weight loss and not with other clinical findings. Am J Clin Pathol 118:582–588
Mant MJ, Faragher BS (1972) The haematology of anorexia nervosa. Br J Haematol 23:737–749
Di Pascoli L, Lion A, Milazzo D et al (2004) Acute liver damage in anorexia nervosa. Int J Eat Disord 36:114–117
Krantz MJ, Lee D, Donahoo WT et al (2005) The paradox of normal serum albumin in anorexia nervosa: a case report. Int J Eat Disord 37:278–280
Takakura S, Nozaki T, Nomura Y et al (2006) Factors related to renal dysfunction in patients with anorexia nervosa. Eat Weight Disord 11:73–77
Duncan L, Heathcote J, Djurdjev O, Levin A (2001) Screening for renal disease using serum creatinine: who are we missing? Nephrol Dial Transpl 16:1042–1046
Rich LM, Caine MR, Findling W et al (1990) Hypoglycemic coma in anorexia nervosa. Case report and review of the literature. Arch Intern Med 150:894–895
Takii M, Uchigata Y, Tokunaga S et al (2008) The duration of severe insulin omission is the factor most closely associated with the microvascular complications of type 1 diabetic females with clinical ED. Int J Eat Disord 41:259–264
Mehler PS, Crews C, Weiner K (2004) Bulimia: medical complications. J Womens Health (Larchmt) 13:668–675
Shinohara ET, Swisher-McClure S, Husson M et al (2007) Esophageal cancer in a young woman with bulimia nervosa: a case report. J Med Case Rep 1:160
Modan-Moses D, Yaroslavsky A, Novikov I et al (2003) Stunting of growth as a major feature of anorexia nervosa in male adolescents. Pediatrics 111:270–276
Mehler PS (2003) Osteoporosis in anorexia nervosa: prevention and treatment. Int J Eat Disord 33:113–126
Lucas AR, Melton LJ, Crowson CS et al (1999) Long-term fracture risk among women with anorexia nervosa: a population-based cohort study. Mayo Clin Proc 74:972–977
Misra M (2008) Long-term skeletal effects of eating disorders with onset in adolescence. Ann N Y Acad Sci 1135:212–218
Munoz M, Argente J (2002) Anorexia nervosa in female adolescents: endocrine and bone mineral density disturbances. Eur J Endocrinol 147:275–286
Devuyst O, Lambert M, Rodhain J et al (1993) Haematological changes and infectious complications in anorexia nervosa: a case-control study. Q J Med 86:791–799
Nova E, Samartín S, Gómez S et al (2002) The adaptive response of the immune system to the particular malnutrition of eating disorders. Eur J Clin Nutr 56(Suppl 3):S34–S37
Allende LM, Corell A, Manzanares J et al (1998) Immunodeficiency associated with anorexia nervosa is secondary and improves after refeeding. Immunology 94:543–551
Dalle Grave R, Calugi S (2007) Eating disorder not otherwise specified in an inpatient unit: the impact of altering the DSM-IV criteria for anorexia and bulimia nervosa. Eur Eat Disord Rev 15:340–349
Fairburn CG, Cooper Z, Bohn K et al (2007) The severity and status of eating disorder NOS: implications for DSM-V. Behav Res Ther 45:1705–1715
Gualandi M (2011) Medical evaluation of eating disorders: focus on gender differences. In: Strumia R (ed) Eating disorders in males—muscularity and fragility: the two-faced Ianus of male identity. Nova Publisher, New York, pp 107–150
Greenfeld D, Mickley D, Quinlan DM et al (1995) Hypokalemia in outpatients with eating disorders. Am J Psychiatry 152:60–63
Joyce JM, Warren DL, Humphries LL et al (1990) Osteoporosis in women with eating disorders: comparison of physical parameters, exercise, and menstrual status with SPA and DPA evaluation. J Nucl Med 31:325–331
Naessén S, Carlström K, Glant R et al (2006) Bone mineral density in bulimic women–influence of endocrine factors and previous anorexia. Eur J Endocrinol 155:245–251
Peebles R, Hardy KK, Wilson JL et al (2010) Are diagnostic criteria for eating disorders markers of medical severity? Pediatrics 125:e1193–e1201
Crow SJ, Peterson CB, Swanson SA et al (2009) Increased mortality in bulimia nervosa and other eating disorders. Am J Psychiatry 166:1342–1346
Sullivan PF(1995) Mortality in anorexia nervosa. Am J Psychiatry 152: 1073–1074
Steinhausen HC (2002) The outcome of anorexia nervosa in the 20th century. Am J Psychiatry 159:1284–1293
Fichter MM, Quadflieg N (2004) Twelve-year course and outcome of bulimia nervosa. Psychol Med 34:1395–1406
Pike MK (1998) Long term course of anorexia nervosa: response, relapse, remission and recovery. Clin Psychol Rev 18:447–475
Papadopoulos FC (2009) Excess mortality, causes of death and prognostic factors in anorexia nervosa. Br J Psychiatry 194:10–17
Favaro A, Ferrara S, Santonastaso P (2003) The spectrum of eating disorders in young women: a prevalence study in a general population sample. Psychosom Med 65:701–708
NCCMH (2004) Eating disorders: core interventions in the treatment and management of anorexia nervosa, bulimia nervosa and related eating disorders. The British Psychological Society and the Royal College of Psychiatrists, Leicester
Siegel HJ, Hardoff D, Golden NH et al (1993) Medical complications in male adolescent with anorexia nervosa. J Adolesc Health 16:448–453
Mehler PS, Sabel AL, Watson T et al (2008) High risk of osteoporosis in male patients with ED. Int J Eat Disord 41:666–672
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Scanelli, G., Gualandi, M., Simoni, M. et al. Somatic involvement assessed through a cumulative score of clinical severity in patients with eating disorders. Eat Weight Disord 19, 49–59 (2014). https://doi.org/10.1007/s40519-013-0065-4
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DOI: https://doi.org/10.1007/s40519-013-0065-4