Abstract
Ibuprofen(IBU) and its derivatives are widely used in treating many diseases, such as depression, glomerulonephritis, fever caused by common cold or influenza, and rheumatoid arthritis. While in clinical trials, IBU was found to have many side effects. To weaken and prevent these side effects, a derivative called ibuprofen-1-acetoxyethyl ester was synthesized in this paper. The maximum concentration(c max) in a shorter time was compared with IBU at the same dose.
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Supported by the Development Project of the Pharmaceutical Industry of Jilin Province, China(Nos.20140311088YY, 20150311070YY, 20170307024YY), the Significant Science and Technology Project of Changchun City, China(No.2015054), the Key Science and Technology Project of Jilin Province, China(No.20140204066SF) and the Significant Science and Technology Item of ―Double Ten Project‖ of Changchun City, China(No.16SS12).
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Wang, B., Hou, W., Wang, Y. et al. Synthesis and pharmacodynamics of ibuprofen-1-acetoxyethyl ester. Chem. Res. Chin. Univ. 33, 569–573 (2017). https://doi.org/10.1007/s40242-017-7103-0
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DOI: https://doi.org/10.1007/s40242-017-7103-0