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Development Aspects of Zebrafish Myotendinous Junction: a Model System for Understanding Muscle Basement Membrane Formation and Failure

  • Xenopus and Zebrafish Models for Pathobiology (W Goessling and A Zorn, Section Editors)
  • Published:
Current Pathobiology Reports

Abstract

Purpose of Review

The muscle is separated from tendons by a specialised basement membrane that acts as the structural interface of the myotendinous junction (MTJ). In zebrafish, the larval MTJ forms at the vertical myosepta, which separate the individual myomeres that arise during somitogenesis. In this review, we examine the formation of the vertical myosepta in zebrafish. We then describe insights this gains us in the context of muscle basement membrane failure, the mechanistic basis of the inherited muscle wasting condition muscular dystrophy (MD).

Recent Findings

We examine recent manuscripts that investigate how a well-orchestrated integration of MTJ components is needed during vertical myosepta development. We find the process can be divided into three stereotypical stages of its development based on specific structural properties of the developing basement membrane.

Summary

This review highlights insights that have been gleaned from vertical myosepta formation in zebrafish that maybe of value in developing therapeutic strategies for MD.

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Acknowledgements

PDC is a Principal NHMRC fellow, director of the Australian Regenerative Medicine Institute at Monash University and Head of EMBL Australia Melbourne Node. This work is supported on a NHMRC grant (APP3151883).

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Authors and Affiliations

  1. Australian Regenerative Medicine Institute, Monash University, Wellington Road, Melbourne, Victoria, 3800, Australia

    Alasdair J. Wood & Peter D. Currie

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  1. Alasdair J. Wood
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  2. Peter D. Currie
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Correspondence to Peter D. Currie.

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Conflict of Interest

Dr. Currie reports grants from NHMRC aus, during the conduct of the study.

Dr. Wood declares no conflict of interest.

Human and Animal Rights and Informed Consent

Zebrafish used to generate data complied with the Monash University Animal Ethics Committee and National Health and Medical Research Council of Australia code for care and use of animals for scientific purposes.

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This article is part of the Topical Collection on Xenopus and Zebrafish Models for Pathobiology

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Wood, A.J., Currie, P.D. Development Aspects of Zebrafish Myotendinous Junction: a Model System for Understanding Muscle Basement Membrane Formation and Failure. Curr Pathobiol Rep 5, 197–205 (2017). https://doi.org/10.1007/s40139-017-0140-z

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  • DOI: https://doi.org/10.1007/s40139-017-0140-z

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