Résumé
L’hydrogène sulfuré (H2S) est un gaz incolore, toxique pour l’environnement et malodorant. Il est cependant synthétisé en faible quantité dans l’organisme des mammifères et constitue un gazotransmetteur endogène, jouant un rôle important en physiopathologie. On lui attribue des propriétés vasodilatatrices: il participerait au contrôle de la pression artérielle, aux lésions d’ischémie-reperfusion cardiaques et jouerait un rôle dans l’inflammation. Au cours des dernières années, l’H2S, les donneurs et inhibiteurs de l’H2S ont ainsi suscité un intérêt grandissant, notamment en réanimation, et ont été étudiés sur différents modèles animaux. Les effets de l’H2S restent pourtant en partie débattus, puisqu’il peut tantôt revêtir les caractéristiques d’une molécule au potentiel thérapeutique intéressant, tantôt se distinguer par ses effets délétères. Ce travail constitue une mise au point sur les différentes propriétés de l’H2S pour tenter d’identifier un éventuel intérêt de ce gaz en réanimation.
Abstract
Hydrogen sulfide (H2S) is a gaseous mediator, which has an important role in pathophysiology. It is a vasodilator gas, taking part in particular in the regulation of blood pressure, in the cardiac response to ischemia/reperfusion injury, and in inflammation. In recent decades, H2S and its donors/inhibitors have therefore been studied with growing interest in intensive care units and tested in various animal models; the roles of H2S are still a matter of debate, as it can be considered either a molecule with potential beneficial effect or deleterious. This review summarizes the different properties of H2S in order to point its potential value in intensive care.
Article PDF
Avoid common mistakes on your manuscript.
Références
Wang R (2002) Two’s company, three’s a crowd: can H2S be the third endogenous gaseous transmitter? FASEB J 16:1792–1798
Caliendo G, Cirino G, Santagada V, Wallace JL (2010) Synthesis and biological effects of hydrogen sulfide (H2S): development of H2S-releasing drugs as pharmaceuticals. J Med Chem 53:6275–6286
Olson KR (2011) The therapeutic potential of hydrogen sulfide: separating hype from hope. Am J Physiol Regul Integr Comp Physiol 301:R297–R312
Hughes MN, Centelles MN, Moore KP (2009) Making and working with hydrogen sulfide: the chemistry and generation of hydrogen sulfide in vitro and its measurement in vivo: a review. Free Radic Biol Med 47:1346–1353
Gadalla MM, Snyder SH (2010) Hydrogen sulfide as a gasotransmitter. J Neurochem 113:14–26
Reiffenstein RJ, Hulbert WC, Roth SH (1992) Toxicology of hydrogen sulfide. Annu Rev Pharmacol Toxicol 32:109–134
Cooper CE, Brown GC (2008) The inhibition of mitochondrial cytochrome-oxidase by the gases carbon monoxide, nitric oxide, hydrogen cyanide and hydrogen sulfide: chemical mechanism and physiological significance. J Bioenerg Biomembr 40:533–539
Dorman DC, Moulin FJ, McManus BE, et al (2002) Cytochromeoxidase inhibition induced by acute hydrogen sulfide inhalation: correlation with tissue sulfide concentrations in the rat brain, liver, lung, and nasal epithelium. Toxicol Sci 65:18–25
Kage S, Nagata T, Kudo K (1991) Determination of polysulphides in blood by gas chromatography and gas chromatographymass spectrometry. J Chromatogr 564:163–169
The hypothermia after cardiac arrest study group (2002) Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 346:549–556
Polderman KH (2008) Induced hypothermia and fever control for prevention and treatment of neurological injuries. Lancet 371:1955–1969
Padilla PA, Roth MB (2001) Oxygen deprivation causes suspended animation in the zebrafish embryo. Proc Natl Acad Sci U S A 98:7331–7335
Moore PK, Bhatia M, Moochhala S (2003) Hydrogen sulfide: from the smell of the past to the mediator of the future? Trends Pharmacol Sci 24:609–611
Blackstone E, Morrison M and Roth MB (2005) H2S induces a suspended animation-like state in mice. Science 308:518
Blackstone E, Roth MB (2007) Suspended animation-like state protects mice from lethal hypoxia. Shock 27:370–372
Minard FN, Grant DS (1982) Hypothermia as a mechanism for drug-induced resistance to hypoxia. Biochem Pharmacol 31:1197–1203
Simon F, Scheuerle A, Gröger M, et al (2011) Effects of intravenous sulfide during porcine aortic occlusion-induced kidney ischemia/reperfusion injury. Shock 35:156–163
Remick DG, Xioa H (2006) Hypothermia and sepsis. Front Biosci 11:1006–1013
Hagiwara S, Iwasaka H, Matsumoto S, Noguchi T (2007) Changes in cell culture temperature alter release of inflammatory mediators in murine macrophagic RAW264.7 cells. Inflamm Res 56:297–303
L’Her E, Amerand A, Vettier A, Sebert P (2006) Effects of mild induced hypothermia during experimental sepsis. Crit Care Med 34:2621–2623
Wagner F, Wagner K, Weber S, et al (2011) Inflammatory effects of hypothermia and inhaled H2S during resuscitated, hyperdynamic murine septic shock. Shock 35:396–402
Haouzi P (2011) Murine models in critical care research. Crit Care Med 39:2290–2293
Derwall M, Francis RC, Kida K, et al (2011) Administration of hydrogen sulfide via extracorporeal membrane lung ventilation in sheep with partial cardiopulmonary bypass perfusion: a proof of concept study on metabolic and vasomotor effects. Crit Care 15:R51
Wagner K, Georgieff M, Asfar P, et al (2011) Of mice and men (and sheep, swine, etc.): the intriguing hemodynamic and metabolic effects of hydrogen sulfide (H2S). Crit Care 15:146
Furchgott RF, Zawadzki JV (1980) The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288:373–376
Zhao W, Zhang J, Lu Y, Wang R (2001) The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel opener. EMBO J 20:6008–6016
Elsey DJ, Fowkes RC, Baxter GF (2010) Regulation of cardiovascular cell function by hydrogen sulfide (H(2)S). Cell Biochem Funct 28:95–106
Ali MY, Ping CY, Mok YY, et al (2006) Regulation of vascular nitric oxide in vitro and in vivo; a new role for endogenous hydrogen sulphide? Br J Pharmacol 149:625–634
Whiteman M, Li L, Kostetski I, et al (2006) Evidence for the formation of a novel nitrosothiol from the gaseous mediators nitric oxide and hydrogen sulphide. Biochem Biophys Res Commun 343:303–310
Hui Y, Du J, Tang C, et al (2003) Changes in arterial hydrogen sulfide (H(2)S) content during septic shock and endotoxin shock in rats. J Infect 47:155–160
Mok YY, Atan MS, Yoke Ping C, et al (2004) Role of hydrogen sulphide in haemorrhagic shock in the rat: protective effect of inhibitors of hydrogen sulphide biosynthesis. Br J Pharmacol 143:881–889
Whitfield NL, Kreimier EL, Verdial FC, et al (2008) Reappraisal of H2S/sulfide concentration in vertebrate blood and its potential significance in ischemic preconditioning and vascular signaling. Am J Physiol Regul Integr Comp Physiol 294:R1930–R1937
Dombkowski RA, Russell MJ, Schulman AA, et al (2005) Vertebrate phylogeny of hydrogen sulfide vasoactivity. Am J Physiol Regul Integr Comp Physiol 288:R243–R252
Koenitzer JR, Isbell TS, Patel HD, et al (2007) Hydrogen sulfide mediates vasoactivity in an O2-dependent manner. Am J Physiol Heart Circ Physiol 292:H1953–H1960
Morrison ML, Blackwood JE, Lockett SL, et al (2008) Surviving blood loss using hydrogen sulfide. J Trauma 65:183–188
Ganster F, Burban M, de la Bourdonnaye M, et al (2010) Effects of hydrogen sulfide on hemodynamics, inflammatory response and oxidative stress during resuscitated hemorrhagic shock in rats. Crit Care 14:R165
Geng B, Yang J, Qi Y, et al (2004) H2S generated by heart in rat and its effects on cardiac function. Biochem Biophys Res Commun 313:362–368
Cole WC, McPherson CD, Sontag D (1991) ATP-regulated K+ channels protect the myocardium against ischemia/reperfusion damage. Circ Res 69:571–581
Ji Y, Pang QF, Xu G, et al (2008) Exogenous hydrogen sulfide postconditioning protects isolated rat hearts against ischemiareperfusion injury. Eur J Pharmacol 587:1–7
Xu M, Wu YM, Li Q, et al (2008) Electrophysiological effects of hydrogen sulfide on pacemaker cells in sinoatrial nodes of rabbits. Sheng Li Xue Bao 60:175–180
Szabo C (2007) Hydrogen sulphide and its therapeutic potential. Nat Rev Drug Discov 6:917–935
Sivarajah A, McDonald MC, Thiemermann C (2006) The production of hydrogen sulfide limits myocardial ischemia and reperfusion injury and contributes to the cardioprotective effects of preconditioning with endotoxin, but not ischemia in the rat. Shock 26:154–161
Pan TT, Feng ZN, Lee SW, et al (2006) Endogenous hydrogen sulfide contributes to the cardioprotection by metabolic inhibition preconditioning in the rat ventricular myocytes. J Mol Cell Cardiol 40:119–130
Geng B, Chang L, Pan C, et al (2004) Endogenous hydrogen sulfide regulation of myocardial injury induced by isoproterenol. Biochem Biophys Res Commun 318:756–763
Johansen D, Ytrehus K and Baxter GF (2006) Exogenous hydrogen sulfide (H2S) protects against regional myocardial ischemiareperfusion injury-evidence for a role of K ATP channels. Basic Res Cardiol 101:53–60
Bian JS, Yong QC, Pan TT, et al (2006) Role of hydrogen sulfide in the cardioprotection caused by ischemic preconditioning in the rat heart and cardiac myocytes. J Pharmacol Exp Ther 316:670–678
Hu Y, Chen X, Pan TT, et al (2008) Cardioprotection induced by hydrogen sulfide preconditioning involves activation of ERK and PI3K/Akt pathways. Pflugers Arch 455:607–616
Yong QC, Lee SW, Foo CS, et al (2008) Endogenous hydrogen sulphide mediates the cardioprotection induced by ischemic postconditioning. Am J Physiol Heart Circ Physiol 295:H1330–H1340
Elrod JW, Calvert JW, Morrison J, et al (2007) Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function. Proc Natl Acad Sci U S A 104:15560–15565
Lu M, Hu LF, Hu G, Bian JS (2008) Hydrogen sulfide protects astrocytes against H(2)O(2)-induced neural injury via enhancing glutamate uptake. Free Radic Biol Med 45:1705–1713
Whiteman M, Armstrong JS, Chu SH, et al (2004) The novel neuromodulator hydrogen sulfide: an endogenous peroxynitrite ‘scavenger’? J Neurochem 90:765–768
Whiteman M, Cheung NS, Zhu YZ, et al (2005) Hydrogen sulphide: a novel inhibitor of hypochlorous acid-mediated oxidative damage in the brain? Biochem Biophys Res Commun 326:794–798
Kimura Y, Kimura H (2004) Hydrogen sulfide protects neurons from oxidative stress. FASEB J 18:1165–1167
Kimura Y, Goto Y, Kimura H (2010) Hydrogen sulfide increases glutathione production and suppresses oxidative stress in mitochondria. Antioxid Redox Signal 12:1–13
Kimura Y, Dargusch R, Schubert D, Kimura H (2006) Hydrogen sulfide protects HT22 neuronal cells from oxidative stress. Antioxid Redox Signal 8:661–670
Tan BH, Wong PT, Bian JS (2010) Hydrogen sulfide: a novel signaling molecule in the central nervous system. Neurochem Int 56:3–10
Sivarajah A, Collino M, Yasin M, et al (2009) Anti-apoptotic and anti-inflammatory effects of hydrogen sulfide in a rat model of regional myocardial I/R. Shock 31:267–274
Hu LF, Wong PT, Moore PK, Bian JS (2007) Hydrogen sulfide attenuates lipopolysaccharide-induced inflammation by inhibition of p38 mitogen-activated protein kinase in microglia. J Neurochem 100:1121–1128
Esechie A, Kiss L, Olah G, et al (2008) Protective effect of hydrogen sulfide in a murine model of acute lung injury induced by combined burn and smoke inhalation. Clin Sci (Lond) 115:91–97
Li T, Zhao B, Wang C, et al (2008) Regulatory effects of hydrogen sulfide on IL-6, IL-8 and IL-10 levels in the plasma and pulmonary tissue of rats with acute lung injury. Exp Biol Med (Maywood) 233:1081–1087
Zanardo RC, Brancaleone V, Distrutti E, et al (2006) Hydrogen sulfide is an endogenous modulator of leukocyte-mediated inflammation. FASEB J 20:2118–2120
Aslami H, Heinen A, Roelofs JJ, et al (2010) Suspended animation inducer hydrogen sulfide is protective in an in vivo model of ventilator-induced lung injury. Intensive Care Med 36:1946–1952
Faller S, Ryter SW, Choi AM, et al (2010) Inhaled hydrogen sulfide protects against ventilator-induced lung injury. Anesthesiology 113:104–115
Spiller F, Orrico MI, Nascimento DC, et al (2010) Hydrogen sulfide improves neutrophil migration and survival in sepsis via K +ATP channel activation. Am J Respir Crit Care Med 182:360–368
Collin M, Anuar FB, Murch O, et al (2005) Inhibition of endogenous hydrogen sulfide formation reduces the organ injury caused by endotoxemia. Br J Pharmacol 146:498–505
Zhang H, Bhatia M (2008) Hydrogen sulfide: a novel mediator of leukocyte activation. Immunopharmacol Immunotoxicol 30:631–645
Zhang H, Hegde A, Ng SW, et al (2007) Hydrogen sulfide upregulates substance P in polymicrobial sepsis-associated lung injury. J Immunol 179:4153–4160
Zhang H, Moochhala SM, Bhatia M (2008) Endogenous hydrogen sulfide regulates inflammatory response by activating the ERK pathway in polymicrobial sepsis. J Immunol 181:4320–4331
Zhang H, Zhi L, Moochhala S, et al (2007) Hydrogen sulfide acts as an inflammatory mediator in cecal ligation and punctureinduced sepsis in mice by upregulating the production of cytokines and chemokines via NF-kappaB. Am J Physiol Lung Cell Mol Physiol 292:L960–L971
Zhang H, Zhi L, Moochhala SM, et al (2007) Endogenous hydrogen sulfide regulates leukocyte trafficking in cecal ligation and puncture-induced sepsis. J Leukoc Biol 82:894–905
Zhang H, Zhi L, Moore PK, Bhatia M (2006) Role of hydrogen sulfide in cecal ligation and puncture-induced sepsis in the mouse. Am J Physiol Lung Cell Mol Physiol 290:L1193–L1201
Zhi L, Ang AD, Zhang H, et al (2007) Hydrogen sulfide induces the synthesis of proinflammatory cytokines in human monocyte cell line U937 via the ERK-NF-kappaB pathway. J Leukoc Biol 81:1322–1332
Whiteman M, Li L, Rose P, et al (2010) The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators in macrophages. Antioxid Redox Signal 12:1147–1154
Wagner F, Asfar P, Calzia E, et al (2009) Bench-to-bedside review: Hydrogen sulfide-the third gaseous transmitter: applications for critical care. Crit Care 13:213
Baskar R, Sparatore A, Del Soldato P, Moore PK (2008) Effect of S-diclofenac, a novel hydrogen sulfide releasing derivative inhibit rat vascular smooth muscle cell proliferation. Eur J Pharmacol 594:1–8
Yang G, Sun X, Wang R (2004) Hydrogen sulfide-induced apoptosis of human aorta smooth muscle cells via the activation of mitogen-activated protein kinases and caspase-3. FASEB J 18:1782–1784
Yang G, Wu L, Wang R (2006) Pro-apoptotic effect of endogenous H2S on human aorta smooth muscle cells. FASEB J 20:553–555
Meng QH, Yang G, Yang W, et al (2007) Protective effect of hydrogen sulfide on balloon injury-induced neointima hyperplasia in rat carotid arteries. Am J Pathol 170:1406–1414
Baskar R, Li L, Moore PK (2007) Hydrogen sulfide-induces DNA damage and changes in apoptotic gene expression in human lung fibroblast cells. FASEB J 21:247–255
Author information
Authors and Affiliations
Corresponding author
Additional information
Cet article correspond à la conférence faite par l’auteur au congrès de la SRLF 2012 dans la session: Plein gaz.
Rights and permissions
About this article
Cite this article
Boisramé-Helms, J., Asfar, P., Radermacher, P. et al. Effets cardiovasculaires de l’hydrogène sulfuré. Réanimation 21 (Suppl 2), 467–474 (2012). https://doi.org/10.1007/s13546-011-0343-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13546-011-0343-y