Abstract
Obesity is associated with development of chronic low grade inflammation that arises from adipose tissue. Obesity-induced inflammation, in which macrophages play a pivotal role, has been shown to induce insulin resistance. More recently, various other immune cells including B- and T-cells have been shown to participate in modulating adipose tissue inflammation. Here we tested the effect of absence of both B- and T-cells in mice during development of obesity-induced inflammation and insulin resistance.
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Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen Institute of Inflammation Immunity and Infection1; Institute of Genetic and Metabolic Disease2. E-mail: d.ballak@aig.umcn.nl
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Ballak, D., Stienstra, R., Hijmans, A. et al. PS2 - 9. Effect of B- and T-cell deficiency on obesity-induced inflammation and insulin resistance. NED. TIJDSCHR. DIABET. 9, 96 (2011). https://doi.org/10.1007/s12467-011-0034-3
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DOI: https://doi.org/10.1007/s12467-011-0034-3