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PS2 - 8. MIDD or MELAS: that’s not the question. a severe clinical phenotype of the m.3243A>G mutation

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Nederlands Tijdschrift voor Diabetologie Aims and scope

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Abstract

MIDD (Maternally Inherited Diabetes and Deafness) and MELAS (Mitochondrial Encephalomyopathy with Lactic Acidosis and Stroke-like episodes) are related syndromes both associated with the m.3243A>G mutation. A patient with this mutation, previously diagnosed with MIDD, is described who showed two remarkable clinical features: severe insulin resistance and the development of MELAS over time.

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Authors and Affiliations

  1. Department of Internal Medicine, Slingeland Hospital, Doetinchem, The Netherlands

    Heleen de Wit & Aart Mudde

  2. Department of Neurology, St Antonius Hospital, Nieuwegein, The Netherlands

    Henk-Jan Westeneng

Authors
  1. Heleen de Wit
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  2. Henk-Jan Westeneng
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  3. Aart Mudde
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Corresponding author

Correspondence to Heleen de Wit.

Additional information

1Department of Internal Medicine, Slingeland Hospital, Doetinchem, The Netherlands; 2Department of Neurology, St Antonius Hospital, Nieuwegein, The Netherlands. E-mail: hmdewit@gmail.com

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de Wit, H., Westeneng, HJ. & Mudde, A. PS2 - 8. MIDD or MELAS: that’s not the question. a severe clinical phenotype of the m.3243A>G mutation. NED. TIJDSCHR. DIABET. 9, 95–96 (2011). https://doi.org/10.1007/s12467-011-0033-4

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  • DOI: https://doi.org/10.1007/s12467-011-0033-4

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