Skip to main content

Advertisement

SpringerLink
Log in

Persoonlijkheid: een belangrijke factor bij de ontwikkeling, behandeling en de preventie van type 2 diabetes.

  • Diabetes onderzoek: Nederlands onderzoek in internationale tijdschriften
  • Published:
Nederlands Tijdschrift voor Diabetologie Aims and scope

Samenvatting

De toegenomen incidentie van type 2 diabetes is deels toe te schrijven aan de huidige obesogene leefomgeving. Er bestaan echter grote individuele verschillen in de ontwikkeling van type 2 diabetes. De persoonlijkheid van een individu is in hoge mate bepalend voor de manier waarop een individu omgaat met zijn omgeving. Dit betekent dat de persoonlijkheid van een individu mogelijk ook een bepalende factor zou kunnen zijn bij de ontwikkeling van type 2 diabetes. Wij hebben dit onderzocht in een diermodel met passieve en proactieve ratten. Passieve ratten bleken een grote aanleg hebben voor het ontwikkelen van insulineresistentie terwijl proactieve ratten, zelfs in een obesogene omgeving, gekenmerkt worden door een hoge insulinegevoeligheid. Ook bij de behandeling van type 2 diabetes werden er verschillen gevonden tussen passieve en proactieve ratten. Dit gold zowel voor farmacologische behandeling met een selectieve glucocorticoïd receptor antagonist als voor life style interventie programma’s, met name op het gebied van fysieke activiteit. De studies bevestigen dat de persoonlijkheid van een individu een belangrijke factor is bij de ontwikkeling en behandeling van type 2 diabetes, met name door de interacties van het individu met zijn leefomgeving. We stellen dat de behandeling van type 2 diabetes sterk zou kunnen verbeteren door rekening te houden met de interactie tussen de leefomgeving van de patiënt, zijn of haar persoonlijkheid en uiteraard de bijbehorende fysiologische kenmerken.

Summary

The increased incidence of type 2 diabetes is for a large part caused by changes in the modern obesogenic environment. There are, however, large individual differences in the development and treatment of type 2 diabetes. Since the personality of the individual is a determining factor for the way this individual interacts with its environment, we hypothesized that the personality may play pivotal role in the development of type 2 diabetes. We investigated this in rats selected for a proactive or passive personality. Passive individuals had a higher susceptibility to develop insulin resistance, while proactive individuals are characterized by a high insulin sensitivity, even in a obesogenic environment. Our studies also revealed a large difference in the response to several treatments. First, treatment with a glucocorticoid antagonist improved insulin profiles in the passive rat, while it did not in the proactive rats. Secondly, running, either spontaneously or forced, resulted in improved insulin sensitivity in both personalities, but when the animals were exposed to a high fat diet, passive rats would increase their spontaneous running levels, whereas proactive rats kept their activity levels stable. We conclude that the interactions between the environment and the personality may play a crucial role in the development or prevention of metabolic diseases such as type 2 diabetes. We feel that that treatment of type 2 diabetes could improve considerably by when the interaction between the environment of the patient, his or her personality and the associated physiological characteristics are taken into account.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figuur 1
Figuur 2
Figuur 3

Referenties:

  1. Elfhag K, Rossner S. Who succeeds in maintaining weight loss? A conceptual review of factors associated with weight loss maintenance and weight regain. Obes.Rev. 2005; 6:67.

    Article  CAS  PubMed  Google Scholar 

  2. Teixeira PJ, Palmeira AL, Branco TL, et al. Who will lose weight? A reexamination of predictors of weight loss in women. Int.J.Behav.Nutr.Phys.Act. 2004; 1:12.

    Article  PubMed Central  PubMed  Google Scholar 

  3. Bortner RW, Rosenman RH. The measurement of pattern A behavior. J. Chronic.Dis. 1967; 20:525.

    Article  CAS  PubMed  Google Scholar 

  4. Goldberg LR. The structure of phenotypic personality traits. Am.Psychol. 1993; 48:26.

    Article  CAS  PubMed  Google Scholar 

  5. Jenkins CD, Zyzanski SJ, Rosenman RH. Progress toward validation of a computer-scored test for the type A coronary- prone behavior pattern. Psychosom.Med. 1971; 33:193.

    Article  CAS  PubMed  Google Scholar 

  6. Koolhaas JM, Korte SM, de Boer SF, et al. Coping styles in animals: current status in behavior and stress-physiology. Neurosci.Biobehav.Rev. 1999; 23:925.

    Article  CAS  PubMed  Google Scholar 

  7. Wechsler B. Coping and coping strategies: a behavioural view. In:43. Applied Animal Behavior Science, 1995; 123.

  8. Benus RF, Bohus B, Koolhaas JM, van Oortmerssen GA. Heritable variation for aggression as a reflection of individualcoping strategies. Experientia 1991;47:1008.

    Article  CAS  PubMed  Google Scholar 

  9. van Oortmerssen GA, Bakker TC. Artificial selection for short and long attack latencies in wild Mus musculus domesticus. Behav.Genet. 1981; 11:115.

    Article  PubMed  Google Scholar 

  10. de Boer SF, Slangen JL, Van der Gugten, J. Plasma catecholamine and corticosterone levels during active and passive shock-prod avoidance behavior in rats: effects of chlordiazepoxide. Physiol Behav. 1990; 47:1089.

    Article  PubMed  Google Scholar 

  11. Engel GL, Schmale AH. Conservation-withdrawal: a primary regulatory process for organismic homeostasis. Ciba Found.Symp. 1972; 8:57.

    CAS  PubMed  Google Scholar 

  12. Korte SM, Beuving G, Ruesink W, Blokhuis HJ. Plasma catecholamine and corticosterone levels during manual restraint in chicks from a high and low feather pecking line of laying hens. Physiol Behav. 1997; 62:437.

    Article  CAS  PubMed  Google Scholar 

  13. Steimer T, la FS, Schulz PE. Neuroendocrine correlates of emotional reactivity and coping in male rats from the Roman high (RHA/Verh)- and low (RLA/Verh)-avoidance lines. Behav.Genet. 1997; 27:503.

    Article  CAS  PubMed  Google Scholar 

  14. de Boer SF, Koolhaas JM. Defensive burying in rodents: ethology, neurobiology and psychopharmacology. Eur.J.Pharmacol. 2003; 463:145.

    Article  PubMed  Google Scholar 

  15. Boersma GJ, Scheurink AJ, Wielinga PY, Steimer TJ, Benthem L. The passive coping Roman Low Avoidance rat, a non-obese rat model for insulin resistance. Physiol Behav. 2009; 97:353.

    Article  CAS  PubMed  Google Scholar 

  16. Boersma GJ, Benthem L, van Dijk G, Steimer TJ, Scheurink AJ. Coping style predicts the (in)sensitivity for developing hyperinsulinemia on a high fat diet in rats. Physiol Behav 2010.; 100:401.

    Article  CAS  PubMed  Google Scholar 

  17. Boersma G, Benthem L, van Dijk G, Steimer TJ, Scheurink AJ. Pharmacological treatment of hyperinsulineamia in rats depends on coping style. Eur.J.Pharmacol 2011.; 654:122–127.

    Article  CAS  PubMed  Google Scholar 

  18. Aubry JM, Bartanusz V, Driscoll P, Schulz P, Steimer T, Kiss JZ. Corticotropin-releasing factor and vasopressin mRNA levels in roman high- and low-avoidance rats: response to open-field exposure. Neuroendocrinology 1995;61:89.

    Article  CAS  PubMed  Google Scholar 

  19. Gentsch C, Lichtsteiner M, Driscoll P, Feer H. Differential hormonal and physiological responses to stress in Roman high- and low-avoidance rats. Physiol Behav. 1982; 28:259.

    Article  CAS  PubMed  Google Scholar 

  20. Boersma GJ, Benthem L, van Dijk G, Scheurink AJ. Individual variation in the (patho)physiology of energy balance. Physiol Behav 2011.; 103:89–97.

    Article  CAS  PubMed  Google Scholar 

  21. Smith TW, MacKenzie J. Personality and risk of physical illness. Annu.Rev.Clin.Psychol. 2006; 2:435.

    Article  PubMed  Google Scholar 

  22. Niaura R, Banks SM, Ward KD, et al. Hostility and the metabolic syndrome in older males: the normative aging study. Psychosom.Med. 2000; 62:7.

    Article  CAS  PubMed  Google Scholar 

  23. Raikkonen K, Hautanen A, Keltikangas-Jarvinen L. Association of stress and depression with regional fat distribution in healthy middle-aged men. J. Behav.Med. 1994; 17:605.

    Article  CAS  PubMed  Google Scholar 

  24. Sovio U, King V, Miettunen J, et al. Cloninger's Temperament dimensions, socio-economic and lifestyle factors and metabolic syndrome markers at age 31 years in the Northern Finland Birth Cohort 1966. J. Health Psychol. 2007; 12:371.

    Article  PubMed  Google Scholar 

  25. Yancura LA, Aldwin CM, Levenson MR, Spiro A, III. Coping, affect, and the metabolic syndrome in older men: how does coping get under the skin? J. Gerontol.B Psychol. Sci.Soc.Sci. 2006; 61:295.

    Article  Google Scholar 

  26. De Meersman RE. Personality, effort perception and cardiovascular reactivity. Neuropsychobiology 1988;19:192.

    Article  CAS  PubMed  Google Scholar 

  27. Hassmen P, Stahl R, Borg G. Psychophysiological responses to exercise in type A/B men. Psychosom.Med. 1993; 55:178.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neuroendocrinology, Center for Behavioral Neurosciences, University of Groningen, 11103, 9700, Groningen, CC, The Netherlands

    Gretha Boersma, Gertjan van Dijk &  Anton Scheurink

  2. Department of Research and Development, AstraZeneca, Göteborg, Sweden

    Bert Benthem

Authors
  1. Gretha Boersma
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bert Benthem
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Gertjan van Dijk
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Anton Scheurink
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Anton Scheurink.

Additional information

1 Department of Neuroendocrinology, Center for Behavioral Neurosciences, University of Groningen, The Netherlands

2 Department of Research and Development, AstraZeneca, Göteborg, Sweden

Correspondentie:

Prof Dr Anton JW Scheurink Department of Neuroendocrinology University of Groningen PO Box 11103 9700 CC Groningen The Netherlands

a.j.w.scheurink@rug.nl

Conflict of interest:

Geen gemeld.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Boersma, G., Benthem, B., van Dijk, G. et al. Persoonlijkheid: een belangrijke factor bij de ontwikkeling, behandeling en de preventie van type 2 diabetes.. NED. TIJDSCHR. DIABET. 9, 46–51 (2011). https://doi.org/10.1007/s12467-011-0015-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12467-011-0015-6

Search

Navigation