Abstract
A series of flavonoids (1–14) was isolated from the roots of Sophora flavescens. We evaluated their ability to inhibit both microbial growth and sortase A, an enzyme that plays a key role in cell wall protein anchoring and virulence in Staphylococcus aureus. Most prenylated flavonoids (7–13) displayed potent inhibitory activity against gram-positive and gram-negative bacteria except E. coli, with minimum inhibitory concentrations values ranging from 4.40 to 27.7 μM, and weak or no activity against fungal strains tested. Kurarinol (6) was a potent inhibitor of sortase A, with an IC50 value of 107.7 ± 6.6 μM. A preliminary structure-activity relationship, including essential structural requirements, is described.
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Oh, I., Yang, WY., Chung, SC. et al. In vitro sortase a inhibitory and antimicrobial activity of flavonoids isolated from the roots of Sophora flavescens. Arch. Pharm. Res. 34, 217–222 (2011). https://doi.org/10.1007/s12272-011-0206-0
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DOI: https://doi.org/10.1007/s12272-011-0206-0