Abstract
We formulated rutin-loaded ethosomes and compared their vesicle size, loading efficiency, stability, and elasticity. In addition, an in vitro skin penetration experiment was performed. The results of the study indicated that ethosomes loaded with 0.005–0.03% rutin were stable during the four-week study period. Among them, those loaded with 0.03% rutin showed a vesicle size (190.20±14.57 nm) and loading efficiency (73.77%±0.01%). Therefore, the in vitro skin penetration experiment was performed using 0.03% rutin-loaded ethosome. Compared to an ethanolic solution of rutin (44.16%), rutin-loaded liposome (37.80%), and a distilled water (DW) solution of rutin (18.31%), rutin-loaded ethosome (93.31 μg; 61.30%) was superior in delivering rutin. Therefore, we suggest that ethosome loaded with 0.03% rutin enhance the skin penetration of rutin and may be used as a drug delivery system for natural cosmetic materials such as flavonoids.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
H. J. Lee, and S. N. Park, J. Soc. Cosmet. Scientists Korea, 37(2), 143 (2011).
H. J. Yang, Y. J. Ahn, J. H. Kim and S. N. Park, J. Soc. Cosmet. Scientists Korea, 34(3), 189 (2008).
J. E. Kim, W.Y. Kim, J.W. Kim, H. S. Park, S.H. Lee, S.Y. Lee, M. J. Kim, A. R. Kim and S. N. Park, J. Soc. Cosmet. Scientists Korea, 36(4), 303 (2010).
S. N. Park, S.Y. Kim, G. N. Lim, N. R. Jo and M. H. Lee, J. Ind. Eng. Chem., 18, 680 (2012).
H. Luo, B. H. Jiang, S.M. King and Y.C. Chen, Nutrition and Cancer, 60(6), 800 (2008).
M. Diana, K. Agata and K. Stefan, IUBMB Life, 41, 1067 (1997).
J. L. Kwang and H.R. Kyung, Korean J. Chem. Eng., 23(5), 779 (2006).
Z. Antonio and L. Roberto, Korean J. Chem. Eng., 28(10), 1965 (2011).
M. S. Lim, M.A. Park, S. S. Kwon and S. B. Han, Polymer (Korea), 36, 705 (2012).
K.Y. Choi, K.H. Min, J. H. Park, K. M. Kim and S.Y. Jung, Polym. Sci. Technol., 20(3), 216 (2009).
B. S. Jin, Y. M. Han, K.H. Lee and M. J. Cho, J. Korean Ind. Eng. Chem., 15, 205 (2004).
S. K. Bae, J.C. Kim, U. K. Jee and J. D. Kim, Korean J. Chem. Eng., 16(1), 56 (1999).
H. J. Gwak and B. S. Jin, J. Korean Ind. Eng. Chem., 18, 130 (2007).
E. J. An, C. K. Kang, J.W. Kim and B. S. Jin, KIC News, 13(4), 24 (2010).
M.M. A. Elsayed, O.Y. Abdallah, V. F. Naggar and N. M. Khalafallah, Int. J. Pharm., 332, 1 (2007).
J. E. Kim, H. J. Lee, M. S. Lim, M. A. Park and S. N. Park, J. Soc. Cosmet. Scientists Korea, 38(1), 15 (2012).
M. S. Lim, S. B. Han, S. S. Kwon, M.A. Park and S. N. Park, J. Soc. Cosmet. Scientists Korea, 38(2), 147 (2012).
S. N. Park, M. H. Lee, S. J. Kim and E. R. Yu, BBRC, 435, 361, (2013).
E. Touitou, N. Dayan, L. Bergelson, B. Godin and M. Eliaz, J. Control. Release, 65, 403 (2000).
E. Touitou, B. Godin and C. Weiss, Drug Dev. Res., 50, 406 (2000).
V. Dubey, D. Mishra, T. Dutta, M. Nahar, D. K. Saraf and N. K. Jain, J. Control. Release, 123, 148 (2007).
Y. P. Fang, Y.H. Tsai, P. C. Wu and Y.B. Huang, Int. J. Pharm., 356, 144 (2008).
D. Paolino, G. Lucania, D. Mardente, F. Alhaique and M. Fresta, J. Control. Release, 106, 99 (2005).
Y. P. Fang, Y. B. Huang, P. C. Wu and Y. H. Tsai, Eur. J. Pharm. Biopharm., 73, 391 (2009).
M. Maria, C. Caddeo, C. Sinico, D. Valenti, M. C. Mostallino, G. Biggio and A.M. Fadda, Eur. J. Pharm. Biopharm., 78, 27 (2011).
S. Jain, A.K. Tiwary, B. Sapra and N.K. Jain, AAPS PharmSciTech., 8, E1 (2007).
S. Jain, P. Jain and N. K. Jain, Drug Dev. Ind. Pharm., 29, 1013 (2003).
S. N. Park, H. J. Lee, H. S. Kim, M. A. Park and H. A. Gu, Korean J. Chem. Eng., 30, 688 (2013).
S. Osanai and K. Nakamura, Biomaterials, 21, 9 (2000).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Park, S.N., Lee, H.J. & Gu, H.A. Enhanced skin delivery and characterization of rutin-loaded ethosomes. Korean J. Chem. Eng. 31, 485–489 (2014). https://doi.org/10.1007/s11814-013-0232-3
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11814-013-0232-3