Abstract
Molecular imprinting, artificial receptors, plastic antibodies are terms associated with synthetic materials capable of chemical and biological sensing. Through the years, these sensors have advanced greatly not only in analytical chemistry; they have high utility for environmental, health, security, military, etc. monitoring and separations applications. New transduction methods and miniaturization have enabled in-situ and real-time sensing capabilities. On the other hand, they have high utility as matrices for chemical and biological separations. The challenge of employing molecularly imprinted polymers or MIPs as receptors lie in demonstrating high selectivity and sensitivity. Robustness and cost are also important considerations. Traditional methods of monolith polymerization employing free radical polymerization mechanisms have yielded good performance but lack the ability to demonstrate repeatable selectivity and sensitivity. Thin films have been deemed to be more useful in sensing applications, but may not offer the right throughput for separations applications. Engineering optimized materials require not only adapting to new chemistries but also knowing their structure-property relationships.
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Rigoberto Advincula is a Professor in the Department of Chemistry and Department of Chemical Engineering at the University of Houston, Texas. He obtained his chemistry degrees from the University of Florida (Ph.D.) and the University of the Philippines (B.S.). He then did Post-doctoral work at the Max Planck Institute for Polymer Research and Stanford University. His research interest includes nanostructured polymer materials and surface analysis. He has published some 380 papers, 11 patents (and pending), and has co-edited the book on Functional Polymer Films, Polymer Brushes, and New Trends in Polymer Science. He currently serves as Editor of Reactive and Functional Polymers and is on the Editorial Boards of Chemistry of Materials, ACS-Applied Materials and Interfaces, Macromolecular Chemistry and Physics, Macromolecular Rapid Communications, Macromolecular Research, Journal of Bioactive and Compatible Polymers, and Polymer for Advance Technologies journals. He is a Fellow of the American Chemical Society (ACS), and also a Fellow of both the Polymer Materials Science and Engineering (PMSE) and the Polymer Chemistry Divisions of the ACS.
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Advincula, R.C. Engineering molecularly imprinted polymer (MIP) materials: Developments and challenges for sensing and separation technologies. Korean J. Chem. Eng. 28, 1313–1321 (2011). https://doi.org/10.1007/s11814-011-0133-2
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DOI: https://doi.org/10.1007/s11814-011-0133-2