Abstract
Jacobson’s necessary condition for optimality guarantees non-negativity of singular second variation, independently of generalized Legendre-Clebsch condition. Fed-batch is a typical singular bioprocess system. However, no reports exist of using Jacobson’s necessary condition in fed-batch optimization problem. This paper suggests its applicability to fed-batch optimization problem by showing its analytical studies for two typical examples: cell mass and metabolite maximization problem.
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References
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Shin, H.S. Analytical studies of Jacobson’s necessary condition for fed-batch singular control optimization. Korean J. Chem. Eng. 28, 886–889 (2011). https://doi.org/10.1007/s11814-010-0448-4
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DOI: https://doi.org/10.1007/s11814-010-0448-4